Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study

Yang, Rongwang; Zhang, Yanyi; Gao, Weijia; Lin, Nannan; Li, Rong; Zhao, Zhengyan

doi:10.1007/s12011-018-1408-9

Cited by 26 publications

(18 citation statements)

References 48 publications

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“…The difference remained when adjusting the factor of gender and age, respectively. This conclusion is the same as previous researches (16). In addition, further point biserial correlation analysis of serum zinc and TD showed that the r value was negative, suggesting a negative correlation between serum zinc and TD.…”

Section: Discussionsupporting

confidence: 91%

“…At present, there are few studies to pay attention to the relationship between copper and tic disorder. Our study showed that serum copper levels in the TD group were lower than that in the control group which is different from previous studies (16). Further analysis based on age, the other two groups obtained similar results as above, whereas for the 2-4 age group, there was no difference in copper levels between the two groups.…”

Section: Discussioncontrasting

confidence: 89%

“…TD coexists with many common comorbidities, the most common of which is attention deficit hyperactivity disorder (ADHD). Some studies have found that serum Zn and Fe levels are lower in children with ADHD than those in normal children, but this phenomenon has not been observed in Mg or Cu (16). Moreover, the results from existing literatures are not always consistent and the parameters of the state of trace elements are also controversial (17).…”

Section: Introductionmentioning

confidence: 97%

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The Blood Levels of Trace Elements Are Lower in Children With Tic Disorder: Results From a Retrospective Study

Qian

You

et al. 2019

Front. Neurol.

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Background: Tic disorders (TD) are common neuropsychiatric disorders among children and adolescents. It is controversial that trace elements may participate in the pathogenesis of TD. Our study aimed to investigate the trace elements status of zinc (Zn), copper (Cu), iron (Fe), and magnesium (Mg) in children with TD, in comparison to healthy controls. Methods: The medical records of eligible TD children and normal healthy children from January 1 to December 31, 2018 in the outpatient clinic were retrospectively reviewed. The clinical information of all subjects were collected including age, gender, diagnosis, previous health records, and serum trace elements level (Cu, Zn, Fe, Mg) at the time of diagnosis before initiating treatment. Results: In total, 1204 TD children (7.63 ± 2.45 years) and 1,220 healthy children (7.27 ± 3.15 years) who were divided into two gender and three age groups (2-4years, 5-9years, ≥10 years) were reviewed in our study. Our study showed that TD children generally had lower whole blood levels of Zn, Cu, Fe than the normal controls (P < 0.01). No significant difference was observed in whole blood levels of Mg. After adjusting for gender, the trends still remained. Further analysis was performed according to age, the trends still remained in Zn and Fe in all age groups (P < 0.05). However, we observed an almost significantly (P = 0.055) lower level of Cu in TD of 2-4 years group while significant differences in other two groups (P < 0.01). Further multiple linear regression and point biserial correlation showed that the lower blood levels of Zn, Cu, and Fe were correlated with the incidence of TD. Conclusion: The present results indicated that lower blood levels of zinc, iron, copper were associated with TD. Trace elements may be used as an auxiliary treatment for TD and need to be further explored.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 89%

Section: Introductionmentioning

confidence: 97%

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The Blood Levels of Trace Elements Are Lower in Children With Tic Disorder: Results From a Retrospective Study

Qian

You

et al. 2019

Front. Neurol.

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“…(19,20). Zinc deficiency also leads to sleep disorders and neurobehavioral abnormalities (15,16). For these reasons, it was thought that colicky infants may have lower plasma Mg or Zn levels than healthy controls and this could be the cause of colic symptoms.…”

Section: Resultsmentioning

confidence: 99%

Plasma Zinc and Magnesium Levels in Infants With Infantile Colic

Büyükgedikli¹,

Kondolot²,

Karakükçü³

et al. 2020

Turkish Journal of Pediatric Disease

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Objective: Muscle cramps, sleep disorders, and irritability due to Mg deficiency; and sleep and behavioral disorders associated with Zn deficiency and being cofactors in the melatonin synthesis have suggested that plasma Mg and Zn may be in lower levels in colicky infants. This study aimed to compare plasma Mg and Zn levels of colicky infants and the mothers with controls. Material and Methods: Fifty infants diagnosed with infantile colic and 22 controls aged 1-3 months with their mothers were included in this cross-sectional study. Colic group was divided into two subgroups; Firts infants who were given Mg-containing herbals (herbals-group, n=12) and second infants who were not given any Mg or Zn-containing supplement (study group, n=27). Plasma Mg and Zn levels were measured by Atomic Absorption Spectrophotometer on flame photometry. Results: Mg levels (mg/dl) of the infants were not different between study group (2.46±0.27) and controls (2.37±0.25) (p=0.70). However, plasma Mg levels were higher in the herbals-group (2.68±1.90) than the study group (2.46±0.27) and controls (2.37±0.25) (p=0.04, p=0,004; respectively). Zn levels (mg/dl) of the infants and Mg and Zn levels of the mothers were not different between the groups (p=0.36, p=0.61, p=0.22; respectively). In the herbals-group, four parents reported that the Mg-containing herbals were useful, but Mg levels of their infants were found similar with the infants whose parents reported that Mg-containing herbals were not useful (p=0.79). Conclusion: Plasma Mg and Zn levels of colicky infants and their mothers were not different from healthy controls in this study. Further studies are needed to determine the effect of Mg supplementation on colic severity.

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“…Beim Aufmerksamkeits-Defizit-Hyperaktivitäts-Syndrom (ADHS) konnte in einer Untersuchung von 419 Patienten gezeigt werden, dass die Kinder signifikant niedrigere Zinkspiegel im Blut aufweisen als die gesunde Vergleichsgruppe, die 395 Kinder umfasst. Gleichzeitig waren die Höhe der Zinkspiegel negativ mit der Schwere der Symptome korreliert [82].…”

Section: Kognitive Und Mentale Störungenunclassified