Blood levels of cytokines in brain-dead patients: Relationship with circulating hormones and acute-phase reactants

Amado, J A; López-Espadas, Francisco; Vázquez-Barquero, Alfonso; Salas, Eduardo; Riancho, José A.; López-Cordovilla, Juan J.; García‐Unzueta, María Teresa

doi:10.1016/0026-0495(95)90198-1

Cited by 152 publications

(97 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Plasma HMGB1 levels were slightly elevated in organ donors already before graft procurement, reflecting a systemic proinflammatory response induced by brain death. [28][29][30] Furthermore, surgical manipulation of the liver during procurement activates Kupffer cells, leading to hepatic expression of proinflammatory mediators. 30,31 Indeed, weak hepatocyte HMGB1 staining was already evident in biopsies taken immediately before graft perfusion during procurement.…”

Section: Discussionmentioning

confidence: 99%

High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation

et al. 2008

View full text Add to dashboard Cite

High mobility group box 1 protein (HMGB1), a cytokine actively secreted by phagocytes and passively released from necrotic cells, is an inflammatory mediator in experimental hepatic ischemia/reperfusion injury. We characterized its expression in human liver transplantation. In 20 patients, in addition to systemic samples, blood was drawn from portal and hepatic veins during and after reperfusion to assess changes within the graft. Plasma HMGB1, tumor necrosis factor ␣ (TNF-␣), and interleukin-6 (IL-6) levels were measured, and HMGB1 immunohistochemistry was performed on biopsies taken before and after reperfusion. Plasma HMGB1 was undetectable before reperfusion, and levels in systemic circulation peaked after graft reperfusion. At portal declamping, HMGB1 levels were substantially higher in the caval effluent [188 (80-371) ng/mL] than in portal venous blood [0 (0-3) ng/mL, P Ͻ 0.001]. HMGB1 release from the graft continued thereafter. HMGB1 levels were not related to TNF-␣ or IL-6 levels. HMGB1 expression was up-regulated in biopsies taken after reperfusion (P ϭ 0.020), with intense hepatocyte and weak neutrophil staining. HMGB1 levels in hepatic venous blood correlated with graft steatosis (r ϭ 0.497, P ϭ 0.03) and peak postoperative alanine aminotransferase levels (r ϭ 0.588, P ϭ 0.008). Our results indicate that HMGB1 originates from the graft and is a marker of hepatocellular injury in human liver transplantation. Liver Transpl 14: 1517Transpl 14: -1525Transpl 14: , 2008

show abstract

Section: Discussionmentioning

confidence: 99%

High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation

et al. 2008

View full text Add to dashboard Cite

show abstract

“…[47][48][49][50] Increased expression of IL-6 and TNF-a has been related to malfunction of donor hearts and prediction of right ventricular failure after human heart transplantation. 51,52 In kidney transplantation, both short-and long-term results of unrelated living transplants are superior to even well-matched cadaveric transplants, [53][54][55] and increased cytokine levels in the blood and kidney of brain-dead donors compared with living donors reflect this difference in outcome between living and cadaveric donation.…”

Section: Inflammatory and Immunological Aspects Of Brain Deathmentioning

confidence: 99%

Brain death and its implications for management of the potential organ donor

Bugge

2009

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

The systemic physiologic changes that occur during and after brain death affect all organs suitable for transplantation. Major changes occur in the cardiovascular, pulmonary, endocrine, and immunological systems, and, if untreated may soon result in cardiovascular collapse and somatic death. Understanding these complex physiologic changes is mandatory for developing effective strategies for donor resuscitation and management in such a way that the functional integrity of potentially transplantable organs is maintained. This review elucidates these physiological changes and their consequences, and based on these consequences the rationale behind current medical management of brain-dead organ donors is discussed.

show abstract

“…Although increased serum IL-6 levels were found in children with acute respiratory infections and in brain-dead patients, TNF-a and IL-1 concentrations were generally normal. 18,19 Boelen et al 36 studied the levels of interferon-g, IL-8 and IL-10 in ESS patients and found no evidence that they had a pathogenic role.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16] Moreover, serum IL-6 levels were negatively correlated with serum FT 3 in ESS. [17][18][19][20][21][22][23] It is generally agreed that ESS is associated with increased cytokine production, but the degree of cytokine involvement and their specific roles in the pathogenesis of ESS remain to be elucidated.…”

mentioning

confidence: 99%

Relationship between circulating cytokine levels and thyroid function following bone marrow transplantation

Lee

Kang

et al. 2004

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:The relation between thyroid hormone changes and cytokines in bone marrow transplantation (BMT) patients has not been studied. This prospective study was designed to determine the relation between thyroid hormones and cytokine levels after BMT and their effects on the mortality. We studied 80 patients undergoing allogeneic BMT. Serum thyroid hormone parameters and cytokine levels were measured before and serially during 6 months after BMT. Serum T 3 decreased to a nadir 3 weeks post-BMT and serum T 4 was lowest at 3 months post-BMT. Serum thyroid stimulating hormone (TSH) sharply decreased to a nadir at 1 week and recovered. Serum interleukin-6 increased for 2 weeks after BMT and declined thereafter. Serum tumor necrosis factor-a increased for 3 weeks after BMT and declined thereafter. After 3 weeks post-BMT, both cytokine levels were negatively correlated with serum T 3 and T 4 levels. A total of 29 patients died before 1 year post-BMT and 51 patients survived longer than 1 year. Those patients who died before 1 year post-BMT had significantly lower levels of T 4 at 3 weeks, 3 and 6 months than surviving patients. In conclusion, increased levels of serum IL-6 and TNF-a were negatively correlated with thyroid hormone concentrations in BMT recipients suggesting the role of these cytokines in euthyroid sick syndrome.

show abstract

Blood levels of cytokines in brain-dead patients: Relationship with circulating hormones and acute-phase reactants

Cited by 152 publications

References 29 publications

High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation

High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation

Brain death and its implications for management of the potential organ donor

Relationship between circulating cytokine levels and thyroid function following bone marrow transplantation

Contact Info

Product

Resources

About