BloodDDIT4andTRIM13transcript levels mark the early stages of Machado-Joseph disease
Ana F. Ferreira,
Mafalda Raposo,
Emily D. Shaw
et al.
Abstract:Machado-Joseph disease (MJD) is a rare late-onset polyglutamine neurodegenerative disease caused by the expansion of a CAG repeat in theATXN3gene encoding the ataxin- 3 (ATXN3) protein. Several studies have identified changes in the abundance of select transcripts and proteins in blood samples of MJD mutation carriers. Here, we aimed to: 1) identify blood transcriptional changes that could be potential biomarkers of MJD from preclinical to symptomatic disease stages; 2) correlate levels of differentially expre… Show more
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