Blood histamine and solid malignant tumors

Cm, Moriarty; Jl, Stucky; Kw, Hamburger; Kd, Patil; Jf, Foley; Rr, Koefoot

doi:10.1007/bf00398182

Cited by 24 publications

(5 citation statements)

References 25 publications

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“…Its mechanisms of action are multifactorial with histamine reported to be a potential growth factor for melanoma cells, breast and colon cancer cell lines [11]; involved in regulation of angiogenesis and an inhibitor of the immune response. Interestingly histamine levels have been shown to be nearly 3 times greater in humans with solid malignant tumours [12]. Cimetidine has also been shown to inhibit E-selectin expression resulting in decreased tumour cell extravasation [13].…”

Section: Reviewmentioning

confidence: 99%

Malignant melanoma in a grey horse: case presentation and review of equine melanoma treatment options

Metcalfe¹,

O’Brien²,

Papakonstantinou³

et al. 2013

Ir Vet J

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A 15 year-old grey Thoroughbred gelding presented for investigation of chronic weight loss and recent onset of respiratory difficulty. Clinical examination confirmed tachypnoea with increased respiratory effort. Thoracic ultrasound examination detected pleural effusion. The dyspnoea was related to the large volume of pleural effusion and, following post-mortem examination, to the presence of a large mediastinal mass. Multiple pigmented masses, likely melanomas, were detected peri-anally. Thoracic radiography, cytological examination of the pleural fluid and a fine needle aspirate of a thoracic mass led to a presumptive diagnosis of malignant melanoma and this was confirmed at post mortem examination. Further metastatic spread to the central nervous system and right guttural pouch was also identified. In conclusion this case manifests the potential malignant behaviour of equine melanomas, and a review of proposed therapies for melanoma treatment highlights the therapeutic options and current areas of research.

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Section: Reviewmentioning

confidence: 99%

Malignant melanoma in a grey horse: case presentation and review of equine melanoma treatment options

Metcalfe¹,

O’Brien²,

Papakonstantinou³

et al. 2013

Ir Vet J

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“…CRC tissues exhibit high levels of histamine in contrast to healthy tissues ( Chanda and Ganguly, 1987 ; Reynolds et al, 1997 ). A clinical study revealed that patients with malignant solid tumors had significantly higher blood histamine levels, which were normalized after surgical excision of the cancer tissues ( Moriarty et al, 1988 ). Moreover, the function of the histidine decarboxylase enzyme, which is involved in histamine synthesis, is reported to be two-fold higher in CRC specimens than in healthy tissues ( Garcia-Caballero et al, 1988 ; Moriarty et al, 1988 ).…”

Section: Discussionmentioning

confidence: 99%

“…A clinical study revealed that patients with malignant solid tumors had significantly higher blood histamine levels, which were normalized after surgical excision of the cancer tissues ( Moriarty et al, 1988 ). Moreover, the function of the histidine decarboxylase enzyme, which is involved in histamine synthesis, is reported to be two-fold higher in CRC specimens than in healthy tissues ( Garcia-Caballero et al, 1988 ; Moriarty et al, 1988 ). Exogenous administration of histamine accelerated the growth of in vivo tumor xenografts in mice, which supports the positive association between histamine and CRC ( Tomita and Okabe, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells

Baniya,

Kim,

Chun

2024

Front. Pharmacol.

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IntroductionColorectal cancer is a highly aggressive and metastatic cancer with inadequate clinical outcomes. Given the crucial role of histamine and histamine receptors in colorectal carcinogenesis, this study aimed at exploring the anticancer effects of terfenadine against colorectal cancer HCT116 cells and elucidate its underlying mechanism.MethodsHerein, we examined the effect of terfenadine on growth and proliferation of HCT116 cells in vitro and in vivo. Various experimental techniques such as flow cytometry, western blot, immunoprecipitation, luciferase assay were employed to unveil the mechanism of cell death triggered by terfenadine.ResultsTerfenadine markedly attenuated the viability of HCT116 cells by abrogating histamine H1 receptor (H1R) signaling. In addition, terfenadine modulated the balance of Bax and Bcl-2, triggering cytochrome c discharge in the cytoplasm, thereby stimulating the caspase cascade and poly-(ADP-ribose) polymerase (PARP) degradation. Moreover, terfenadine suppressed murine double minute-2 (Mdm2) expression, whereas p53 expression increased. Terfenadine suppressed STAT3 phosphorylation and expression of its gene products by inhibiting MEK/ERK and JAK2 activation in HCT116 cells. Furthermore, treatment with U0126, a MEK inhibitor, and AG490, a JAK2 inhibitor, dramatically diminished the phosphorylations of ERK1/2 and JAK2, respectively, leading to STAT3 downregulation. Likewise, terfenadine diminished the complex formation of MEK1/2 with β-arrestin 2. In addition, terfenadine dwindled the phosphorylation of PKC substrates. Terfenadine administration (10 mg/kg) substantially retarded the growth of HCT116 tumor xenografts in vivo.ConclusionTerfenadine induces the apoptosis of HCT116 cells by abrogating STAT3 signaling. Overall, this study supports terfenadine as a prominent anticancer therapy for colorectal cancer.

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“…In addition, the blood levels of histamine in patients with a newly diagnosed solid tumor are nearly three-fold greater than in healthy individuals or noncancerous disease controls. Following surgical removal of the malignancy, the level of histamine remains high for 2 months and then drops to the normal range by 3 months after surgery [117]. Collec-…”

Section: Histamine In Cancer Progressionmentioning

confidence: 99%

Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets

Nguyen

Cho

2021

Biomolecules

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High levels of histamine and histamine receptors (HRs), including H1R~H4R, are found in many different types of tumor cells and cells in the tumor microenvironment, suggesting their involvement in tumor progression. This review summarizes the latest evidence demonstrating the pathophysiological roles of histamine and its cognate receptors in cancer biology. We also discuss the novel therapeutic approaches of selective HR ligands and their potential prognostic values in cancer treatment. Briefly, histamine is highly implicated in cancer development, growth, and metastasis through interactions with distinct HRs. It also regulates the infiltration of immune cells into the tumor sites, exerting an immunomodulatory function. Moreover, the effects of various HR ligands, including H1R antagonists, H2R antagonists, and H4R agonists, on tumor progression in many different cancer types are described. Interestingly, the expression levels of HR subtypes may serve as prognostic biomarkers in several cancers. Taken together, HRs are promising targets for cancer treatment, and HR ligands may offer novel therapeutic potential, alone or in combination with conventional therapy. However, due to the complexity of the pathophysiological roles of histamine and HRs in cancer biology, further studies are warranted before HR ligands can be introduced into clinical settings.

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Blood histamine and solid malignant tumors

Cited by 24 publications

References 25 publications

Malignant melanoma in a grey horse: case presentation and review of equine melanoma treatment options

Malignant melanoma in a grey horse: case presentation and review of equine melanoma treatment options

Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells

Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets

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