Blood Groups (ABO, M-N and Rh), ABH Secretion, Sickle-Cell, P.T.C. Taste, and Colour Blindness in the Mahar of Nagpur

Das, Santanu; Kumar, Nagendra; Bhatacharjee, P. N.; Sastry, D.B.

doi:10.2307/2844419

Cited by 9 publications

(9 citation statements)

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“…As seen in Table 4, the prevalence of the b S gene has varied from study to study and from district to district when describing the same ethnic group (2,9,11,21,30,32,34,43).…”

Section: Discussionmentioning

confidence: 96%

“…Variations in the prevalence of the b S gene have been reported in various Scheduled Castes (SC) and Scheduled Tribes (ST) within different regions throughout India. There have been several previous studies on community screening in different communities for the b S gene but the number of individuals studied have been few; some studies have been hospital-based and the methodology used has not been uniform (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). While sickle cell disease is common among many different ethnic groups, high prevalence has been reported in three historically disadvantaged ethnic categories: the SC, the ST and Other Backward Class (OBC) groups in India .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of the β^SGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

et al. 2014

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Sickle cell disease is an inherited disorder of the blood, and characterized by vasoocclusive crises (VOC), risks for pneumococcal infections and organ toxicities, is associated with morbidity and premature mortality. India, with a population of 1.2 billion individuals, is estimated to be home to over 50.0% of the world's patients with sickle cell disease. The β(S) gene [β6(A3)Glu→Val; HBB: c.20A>T] has the highest prevalence in three socio-economically disadvantaged ethnic categories: the Scheduled Castes (SC), the Scheduled Tribes (ST), and Other Backward Class (OBC) groups in India. The tradition of endogamy practiced by the ethnic groups in India provides the rationale for the screening of individual populations to better understand the distribution of the β(S) gene, guide counseling and awareness programs and aid development of public policy. We undertook a study to describe the prevalence of the β(S) gene in these ethnic groups in the district of Nagpur, Maharashtra in Central India. Through community screening and subsequent targeted screening of high risk individuals, 35,636 individuals were screened, of whom 5466 were found to have sickle cell trait and 1010 were identified with sickle cell disease. Community screening revealed a sickle cell trait prevalence of 13.0% in the SC, 12.0% in the ST and 3.4% in the OBC population. This study describes the prevalence of the β(S) gene within these groups in Central India determined by large scale community screening. This program has uncovered previously undiagnosed cases, provided detailed information to guide population-based disease counseling, prevention and comprehensive care programs.

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“…As seen in Table 4, the prevalence of the b S gene has varied from study to study and from district to district when describing the same ethnic group (2,9,11,21,30,32,34,43).…”

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Prevalence of the β^SGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

et al. 2014

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“…From the present study it may be stated that the presence of HbS among higher communities pave the way of transmitting this gene in to lower castes during ancient period as the higher caste people used to sexually exploit socially and economically backward populations. To suppress this fact, there was planned and a thoughtful view of earlier researchers [10,44] who stigmatised the Mahar from central India with the high rate of sickling so that the label of high SCA could remains with them. With the advent of modern technology it has been cleared now that the earlier food habit has nothing to do with the occurrence of sickle cell or thalassaemia in man.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier reports show a very high frequency of sickle cell trait (> 20 percents) among the Mahar, Kurmi, Panka, Otkar, Pardhan, Pawara, Bhil etc. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. β-thalassaemia is a major monogenic single gene disorder resulting from a reduced or absent synthesis of β-globin chain.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Sickle Cell Anaemia and Thalassaemia in Central India

Urade¹

2012

OJBD

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Haemoglobinopathies are group of diseases characterized by abnormalities both quantitative and qualitative in the synthesis of haemoglobin. Haemoglobinopathies consist of sickle cell anaemia (SCA), thalassaemia (β T ) and variant haemoglobins. In India, they are responsible for the largest number of genetic disorders and hence are of great public health hazardous. In India major concerned haemoglobinopathic disorders are sickle cell anaemia and β-thalassaemia. Of the several abnormal haemoglobin molecules, four which are widely prevalent in India include: HbS, Hbβ T , HbE and HbD. Examination of 6463 individuals showed high incidences for haemoglobin variants, HbS and Hbβ T in different ethnic groups, the frequency being varies from 0% -20% and 0% -9% respectively. The frequency of HbS in Brahmins is 4.17%, in Kalar 5.41%, in Rajput 2.04%, in Muslims 3.73% in Maratha 2.08% in Bania 9.09% while in Teli it is 3.65%. Among the Scheduled castes and Nomadic tribal groups HbS ranges from 1% -12%; in backward caste categories it varies from 3% -16%; while in Scheduled tribes it ranges from 0% -20%. The high magnitude of sickle cell trait has been noticed in the Pardhan (20.31%) followed by the Marar (16.10%), the Dhiwar (11.90%), the Gond (11.89%), the Mahar (11.81%) and the Bania (9.90%). A considerable high frequency (9.27%) of β-thalassaemia has been observed among the Sindhi population. Sporadic occurrence of Hbβ T and HbD among other communities suggested the gradual spread of the genes into the region. The present findings in 11 communities with the thalassaemia syndrome suggest that the β-thalassaemia is accompanied by raised level of HbA 2 . Unusual greater mean RBC and WBC suggest the high concentration of hypochromic microcytosis in anaemia. The mean MCV and MCH in Hbβ T and HbD are much lower than the normal ranges compared to HbS. The mean MCHC is much lower in Hbβ T , HbDD and HbS than the normal range. The cumulative gene frequency of haemoglobinopathies in India is 4.2%. With a population of over 1 billion and a birth rate of 28 per 1000, there are over 42 million carriers and over 12,000 infants are born each year with a major and clinical significant haemoglobinopathy. Out of these, clinically significant sickle cell anaemia and β-thalassaemic disorders account for almost equal numbers.

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“…Lehmann and Cutbush (1952), however, found high sickler rates in some South Indian Veddids which were totally devoid of this " Negro" chromosome R0. Das et al (1961) reported the presence of 20% sicklers in the Mahar, a very low caste in Nagpur district of Madhya Pradesh, associated with but a low R" frequency, slightly above 4% .…”

Section: Inter-group Differences Bctiveen Koraput Tribesmentioning

confidence: 99%

Blood Groups (A<sub>1</sub>A<sub>2</sub>BO, M-N, Rh) and ABH Secretion in the Pareng Gadaba, the Ollaro Gadaba and the Konda Paroja of Koraput District in Orissa

Das¹,

Sastry²,

Mukherjee³

1966

Hum Hered

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Blood Groups (ABO, M-N and Rh), ABH Secretion, Sickle-Cell, P.T.C. Taste, and Colour Blindness in the Mahar of Nagpur

Cited by 9 publications

References 18 publications

Prevalence of the β^SGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

Prevalence of the β^SGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

Incidence of Sickle Cell Anaemia and Thalassaemia in Central India

Blood Groups (A<sub>1</sub>A<sub>2</sub>BO, M-N, Rh) and ABH Secretion in the Pareng Gadaba, the Ollaro Gadaba and the Konda Paroja of Koraput District in Orissa

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Blood Groups (ABO, M-N and Rh), ABH Secretion, Sickle-Cell, P.T.C. Taste, and Colour Blindness in the Mahar of Nagpur

Cited by 9 publications

References 18 publications

Prevalence of the βSGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

Prevalence of the βSGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

Incidence of Sickle Cell Anaemia and Thalassaemia in Central India

Blood Groups (A<sub>1</sub>A<sub>2</sub>BO, M-N, Rh) and ABH Secretion in the Pareng Gadaba, the Ollaro Gadaba and the Konda Paroja of Koraput District in Orissa

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Prevalence of the β^SGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India

Prevalence of the β^SGene Among Scheduled Castes, Scheduled Tribes and Other Backward Class Groups in Central India