Blood group does not appear to affect longevity a pilot study in centenarians from Western Sicily

Vasto, Sonya; Caruso, Calogero; Castiglia, Laura; Duro, Giovanni; Monastero, Roberto; Rizzo, Claudia

doi:10.1007/s10522-011-9350-7

Cited by 8 publications

(10 citation statements)

References 23 publications

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“…Our study does not support the genetic association of ABO alleles with human longevity, as no statistical differences were found between centenarians and middle-aged controls even without multiple comparison correction, which is in agreement with the previous studies. 20,30 Our meta-analysis showed a consistent conclusion.…”

Section: Discussionsupporting

confidence: 79%

“…We carefully reviewed the studies that had previously reported a positive association between ABO blood groups and longevity. [15][16][17]20,30 As listed in Table 5, small sample size and statement for longevity are two common problems, which are critical influencers for population-based studies as the population is heterogeneous and stratified by many hidden or unnoticed factors. In this view, a larger population should produce a more robust statistical estimation.…”

Section: Discussionmentioning

confidence: 99%

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Allelic distribution of ABO gene in Chinese centenarians

et al. 2020

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Allelic distribution of ABO gene in Chinese centenarians

et al. 2020

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“…distribution, since the prevalence of the B type in controls was approximately twice in the Japanese population than in our study. Another small pilot study, including 38 centenarians and 59 subjects aged 45-65 years from Sicily, showed that ABO blood group did not appear to be significantly related with longevity (16). Nevertheless, it cannot be ruled out that the limited number of centenarians enrolled in this previous investigation consistently attenuated the significance of the relationship between ABO blood type and survival.…”

Section: Letters To the Editormentioning

confidence: 77%

Genetic determinants of extreme longevity: the role of ABO blood group

Franchini¹,

Mengoli²,

Bonfanti³

et al. 2016

Thromb Haemost

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Letters to the Editor Dear Sirs, The ABO blood group, the most important among human blood group systems, consists of complex carbohydrate moieties at the extracellular surface of red blood cell (RBC) membrane (1, 2). Along with their expression on RBCs, ABO antigens (namely, A, B, AB and O) are also highly expressed by a large number of human cells and tissues, including epithelia, sensory neurons, platelets and the vascular endothelia (3, 4). It seems thus biologically plausible that the ABO system may expand its clinical significance beyond the traditional boundaries of immunohaematology, transfusion and transplantation medicine. There is growing evidence from the scientific literature that the ABO blood group system may be actively involved in the pathogenesis of a number of human disorders, including cardiovascular, infectious, neoplastic and other diseases (5-8). The fact that ABO blood type may be associated with human disease and may impact on morbidity and death is another intriguing matter of debate, which has stimulated the interest of several investigators over the past 50 years (9, 10). In particular, recent data are supporting the existence of a positive relationship with cardiovascular disorders (11). A particularly interesting model to assess whether the ABO blood groups may contribute or not to promote life extension by eluding most serious diseases is the investigation of the blood

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“…In a study carried out on a small sample of very long-lived Turkish population, no similar association was found [74]. Likewise, in a more recent study conducted in Sicilian centenarians, the ABO blood groups did not appear to affect longevity [75]. In a survey of 269 Japanese centenarians, B allele was found to be associated with longevity [76].…”

Section: Abo Blood Group and Evolutionmentioning

confidence: 88%