Blood group chimerism in human multiple births is not rare

Dijk, B.A. van; Boomsma, Dorret I.; Man, A.J.M. de

doi:10.1002/(sici)1096-8628(19960122)61:3<264::aid-ajmg11>3.0.co;2-r

Cited by 182 publications

(95 citation statements)

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“…DNA is collected from whole blood (e.g., van Dijk et al, 1996) or, in the majority of YNTR families, by buccal swabs (Meulenbelt et al, 1995), which has proven to be successful for microsatellite and short nucleotide polymorphism (SNP) genotyping (Min et al, 2006). Presently, whole-genome SNP data from blood or buccal DNA are available for 3,813 YNTR family members (360 persons participated in both YNTR and ANTR).…”

Section: Dna Collection and Zygosity Typingmentioning

confidence: 99%

“…Depending on the research question, selection of the families is based on the administration database, phenotypic database, or both. For example, studies have selected random groups of twins and siblings, or twins with a specific age or specific birth cohort (Polderman et al, 2006a) or with a specific phenotypic characteristic such as twin pairs having a older sibling (van Leeuwen et al, 2009;van Soelen et al, 2010), twin pairs concordant or discordant for anesthesia (Bartels et al, 2009b) or discordant for attention problems (Derks et al, 2008;Polderman et al, 2006a) van Dijk et al, 1996;12 Lambalk et al, 1998;13 Gur et al, 2001. or pairs with both twins having either a low or a high level of attention problems (van 't Ent et al, 2007).…”

Section: Experimental Studies and In-depth Phenotyping And Endophenotmentioning

confidence: 99%

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The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children

et al. 2012

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The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents.

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Section: Dna Collection and Zygosity Typingmentioning

confidence: 99%

Section: Experimental Studies and In-depth Phenotyping And Endophenotmentioning

confidence: 99%

The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children

et al. 2012

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“…As in our case, the majority of those described previously have occurred in the context of infertility treatment with ovarian stimulation and artificial insemination i.e. IVF or IVF + ICSI [3,6,8,9,[11][12][13][14]16]. Typically numerous embryos were transferred simultaneously.…”

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confidence: 98%

Antenatal Diagnosis of Dizygotic, Monochorionic Twins Following IVF/ICSI

Korsun

Bals‐Pratsch²,

Ortmann

et al. 2016

Geburtshilfe Frauenheilkd

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Abb. 1 Drei Embryonen im 6-bzw. 8-Zell-Stadium vor dem Embryotransfer (Kulturtag 3). Abb. 3 Sagittalschnitt des Körpers vom 1. Feten im Ultraschall mit Darstellung des Penis (siehe Pfeil). Abb. 4 Sagittalschnitt des Körpers vom 2. Feten im Ultraschall mit Darstellung der Klitoris (siehe Pfeil). Abb. 2 Bild der 1. Ultraschalluntersuchung in der 5 + 3 SSW zeigt eine Chorionhöhle mit 2 Dottersäcken.

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“…Pathologic examination confirmed dichorionic diamniotic placentas. The karyotype of the female child was obtained using peripheral blood sample, and it revealed a mixture of 46,XX and 46,XY cells (chi 46,XY [13]/46,XX [7]). FISH analysis performed on the buccal cells by using CEP X/Y probe (Abbott Molecular Inc., USA) revealed 100% XX signals (nuc ish Xcen(DXZ1x2)[500]).…”

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confidence: 99%

“…Blood chimerism has been detected in 8% of twins and 21% of triplets [7]. It has been sug- In this case, the 46,XX/46,XY karyotype was limited to the blood cells, which was consistent with the finding of no definitive abnormality relative to sexual development; however, repeat ultrasonography was necessary.…”

mentioning

confidence: 99%