Blood Formation in Infancy: Part II.--Normal Erythropoiesis

Gairdner, Douglas; Marks, John; Roscoe, Janet D.

doi:10.1136/adc.27.133.214

Cited by 72 publications

(16 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The haematological values of the overall cell population and their changes during the first 3 months of life correspond with those published by other authors [1][2][3][4]. Previous ly only Wintrobe [28] reported a continuous decrease of MCHC during the first trimes ter, but his initial values are extremely high.…”

Section: Discussionsupporting

confidence: 72%

See 1 more Smart Citation

Separation and Characterization of Red Blood Cells from Newborns and Infants during the First Trimenon of Life Using a Dextran Density Gradient: Mean Cellular Volume and Mean Cellular Haemoglobin Concentration

Grauel¹,

Müller²,

Gross³

et al. 1982

Acta Haematol

View full text Add to dashboard Cite

The adaptation of cell physiological parameters of erythrocytes of the newborn to erythrocytes in later life was studied by cell separation in an isopycnic dextran density gradient. The cell characteristics during the first trimester of life were followed by repeated determinations. The mean cellular haemoglobin concentration of the lightest cells is remarkably less than that of the cells of median density. This is probably due to the ongoing synthesis of haemoglobin in reticulocytes, which are highly concentrated in the top fractions. It was shown that the young cells released from the bone marrow become progressively smaller during this period with a decrease of mean cellular volume (MCV) from 104 μm3 at birth to 85 μm3 at the end of the first trimester. It has been established that this process commences during the first week of life. No difference concerning the alterations of cell parameters, especially MCV, in premature and mature infants was found. It is therefore probable that these alterations are due to changes in the external milieu following birth.

show abstract

Section: Discussionsupporting

confidence: 72%

“…Mean cellular hae moglobin (MCH), and mean cellular vol ume (MCV) are known to decrease, where as mean cellular haemoglobin concentration (MCHC) remains essentially constant [2,4,12,14,15,28].…”

mentioning

confidence: 99%

Separation and Characterization of Red Blood Cells from Newborns and Infants during the First Trimenon of Life Using a Dextran Density Gradient: Mean Cellular Volume and Mean Cellular Haemoglobin Concentration

Grauel¹,

Müller²,

Gross³

et al. 1982

Acta Haematol

View full text Add to dashboard Cite

show abstract

“…The next point that arises from our results is the inconsistency between the number of cells that we find in the bone marrow, which is in the region of 2000000 cells/cu mm and the counts ob tained by workers such as G a ir d n er et al (20), who attempted to estimate the activity of the bone marrow of the newborn child by doing absolute cell counts on marrow aspirates. It would be remar kable if our figures were comparable, owing to the variable diluting effect of the circulating marrow blood on marrow aspirates.…”

Section: Discussionmentioning

confidence: 88%

Human Bone Marrow During the Last Three Months of Intrauterine Life

Kalpaktsoglou¹,

Emery²

1965

Acta Haematol

View full text Add to dashboard Cite

“…to infants of various ages (24) indicated that administration to infants from 2 to 8 wk of age generally resulted in less than 80% erythrocyte incorporation of the iron isotope. Moreover, sequential studies of reticulocyte counts and erythropoietic activity of the bone marrow indicated that erythropoiesis in normal term infants falls to low levels by 9 d of age, has begun to increase by 29 d of age, and reaches relatively high levels by 59 d of age (25). It therefore seems likely that from 2 wk until nearly 8 wk of age, erythrocyte incorporation of an administered dose of iron will be less than was observed in the 8-wk-old infants in the present study.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Incorporation of Iron by 56-Day-Old Infants Fed a 58Fe-Labeled Supplement

et al. 1995

View full text Add to dashboard Cite

In an effort to obtain information about absorption of supplemental iron by breast-fed infants during the early months of life, we determined erythrocyte incorporation of a stable iron isotope, administered to 56-d-old breast-fed infants in the form of a 58~e-labeled vitamin-iron supplement. Infants of similar age fed a milk-based formula low in iron (approximately 4 mg/L) were also studied. The 58~e-labeled vitamin-iron supplement was given between feedings. Fourteen days after administration of 58Fe, mean erythrocyte incorporation of the isotope was 7.8% of the dose by breast-fed infants and 4.4% of the dose by formulafed infants. The feeding-related difference was statistically significant, probably reflecting the greater quantities of inhibitors of The term infant is born with a substantial amount of iron in storage sites, and iron stores are increased as the result of decrease in circulating erythrocytes during the early weeks of life. The quantity of storage iron is then sufficient to permit the nearly doubling of erythrocyte mass and muscle mass during the first 4 mo of life, but the transfer of iron from storage sites to active tissues largely depletes storage sites of iron unless exogenous iron is provided. We therefore consider it desirable to supplement the infant's diet with iron beginning soon after birth. This suggestion is not new. More more than 25 y ago the Committee on Nutrition of the American Academy of Pediatrics (I), stated that ". . . the early use of fortified formula results in augmentation of iron stores which helps to prevent later development of iron deficiency." This recommendation for early feeding of iron-fortified formulas has been reaffirmed more recently (2, 3). We believe that for breast-fed infants as iron absorption in the intestines of formula-fed infants. With mean iron intake from the 58Fe-labeled vitamin-iron supplement of 7.99 mg for the breast-fed infants, erythrocyte incorporation of 7.8% of the dose corresponded to 0.62 mg, a value in the range of the estimated requirement for absorbed iron. We conclude that 2-mo-old breast-fed infants are able to absorb nutritionally significant amounts of iron from an iron supplement. (Pediatr Res 38: 373-378, 1995) Abbreviations BV, blood volume IR, isotope ratioAlthough we believe that it is important to augment iron stores, little is known about the extent to which iron is absorbed during the early months of life. The present study was undertaken to obtain information on this point. We studied 56-d-old breast-fed infants given a daily supplement of iron (approximately 7.5 mg/d), and, as a surrogate for iron absorption, determined erythrocyte incorporation of iron using the stable isotope, 5 8~e , as a label. To investigate further the substantially greater erythrocyte incorporation of 5 8~e by breast-fed than by formula-fed infants given a small dose of 5 s~e between feedings (5), we included in the present study a group of formula-fed infants. METHODS Subjects well as for formula-fed infants augmentation of iron storesNormal inf...

show abstract

Blood Formation in Infancy: Part II.--Normal Erythropoiesis

Cited by 72 publications

References 6 publications

Separation and Characterization of Red Blood Cells from Newborns and Infants during the First Trimenon of Life Using a Dextran Density Gradient: Mean Cellular Volume and Mean Cellular Haemoglobin Concentration

Separation and Characterization of Red Blood Cells from Newborns and Infants during the First Trimenon of Life Using a Dextran Density Gradient: Mean Cellular Volume and Mean Cellular Haemoglobin Concentration

Human Bone Marrow During the Last Three Months of Intrauterine Life

Erythrocyte Incorporation of Iron by 56-Day-Old Infants Fed a 58Fe-Labeled Supplement

Contact Info

Product

Resources

About