Blood Flow to the Oviduct of the Nonpregnant Rabbit1

Dickson, W. Michael; Waldhalm, S.J.; Amend, N.

doi:10.1095/biolreprod10.3.335

Cited by 10 publications

(13 citation statements)

References 10 publications

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“…The fact that the redistribu¬ tion of blood flow between the ovary and tube occurs both when the utero-ovarian vessels are undisturbed and clamped, indicate that the ovarian vessels supply and drain the ovary and the tube in rabbits and sheep with very little contribution by the uterine artery and vein. The dominance of the ovarian artery in these species was observed also by Dickson et al (1974) and is in contrast to the findings in the monkey (Wehrenberg et al 1977) and in the human (Janson & Jansson 1977).…”

Section: Direct Blood Flow Measurementscontrasting

confidence: 97%

Blood flow in the ovary and adjacent structures of the non-pregnant sheep

Janson¹,

Williams²,

Petrucco³

et al. 1983

Acta Endocrinologica

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Blood flow to the ovary, vascular pedicle and oviduct was measured in anaesthetized non-cycling and cycling ewes by timed collection of ovarian venous blood. The degree of arterio-venous shunting across the ovary and pedicle was estimated both in vivo and in vitro by perfusing the tissues with 15 \m=+-\5 \g=m\mradioactive micro\x=req-\ spheres.The mean ovarian blood flow in non-cycling animals was 1.9 ml/min, which was 51% of blood flow in the ovarian vein. In cycling animals ovarian blood flow at midcycle was 2.9 ml/min (66% of ovarian venous flow) in non\x=req-\ luteal ovaries and 4.3 ml/min (79% of venous flow) in luteal ovaries. The degree of arterio-venous shunting was low in all stages of the cycle (1.0\p=n-\2.6% across ovary + pedicle). The degree of shunting was also found to be very small in vitro (0.007\p=n-\1.38%) in both non-luteal and luteal ovaries. A considerable number of microspheres was entrapped in the vascular pedicle of the ovary indicating the presence of an extensive capillary bed. There was an inverse relationship between blood flow in the ovary and flow in the vascular pedicle.Alterations in distribution of blood flow between the ovary and adjacent structures supplied by the ovarian artery may be of functional significance in allowing rapid changes in ovarian blood flow. The results of the present study indicate that changes in ovarian blood flow during the oestrous cycle are not caused by an action on arteriovenous shunt vessels.In the search for mechanisms underlying the uter¬ ine control of corpus luteum (CL) function of the ewe, much attention has been paid to the structure of ovarian blood vessels and the rates of blood flow

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Section: Direct Blood Flow Measurementscontrasting

confidence: 97%

Blood flow in the ovary and adjacent structures of the non-pregnant sheep

Janson¹,

Williams²,

Petrucco³

et al. 1983

Acta Endocrinologica

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“…Previously reported values for blood flow through the rabbit uterus are 0-588 ± 0-171 ml min-1 g"1 tissue (Dickson, Waldhalm & Amend, 1974) and 0-910 ± 0-253 ml min"1 g"1 (Waldhalm & Dickson, 1976) in oestrous rabbits when measured by a hydrogen gas technique and 0-75 + 0-06 ml min"1 g"1 with radioactive microspheres (Blasco, Wu, Flickinger, Wheeler & Mikhail, 1973). The control values observed in the present experiments are lower than these, presumably because the animals had been ovariectomized.…”

Section: Discussionmentioning

confidence: 88%

Uterine blood flow and prostaglandin levels in ovariectomized rabbits

Antonini¹,

Valenzuela²,

Harper³

1978

Reproduction

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Summary. Blood flow (measured by radioactive microspheres) through the uteri of ovariectomized rabbits increased significantly by 2 h, was lower at 4 and 8 h, and returned to control values by 24 h after an injection of 25 \g=m\goestradiol-17\g=b\. Blood flow through the kidneys was not affected. Concentrations of PGF and PGE in uterine vein blood were elevated after oestrogen treatment. PGF values were significantly greater than control. PGE concentrations, while elevated, were not significantly different from control, although the pattern of release was similar to that of PGF. Pretreatment of animals with progesterone or L11204, or concurrent treatment with indomethacin did not modify the blood flow through the uterus. It is concluded that the increased uterine blood flow seen after oestrogen treatment is not related to prostaglandin production.

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“…By contrast, metabolism of both PGE-2 and PGF-2cc by oviduct tissue was actually stimulated at 1 h before being depressed at 2 h, but again maximal depression of metabolism was seen between 4 and 6 h after endotoxin. Uterine venous blood of the rabbit can carry a proportion of blood draining from the oviduct (Dickson, Waldhalm & Amend, 1974), but in the experiments in which we measured PG levels following endotoxin injection we sampled from a venous branch draining only uterine tissue (Valenzuela & Harper, 1976), and yet PGF-2a is metabolized only 10-20% as rapidly as PGE-2 (present study). Incubations of whole sections of ampulla or isthmus of 24 h rabbit oviduct for 60 min also give rise to approximately equal quantities of PGF (ampulla: 0-51 ± 0-08 and isthmus: 0-57 ± 0-06 ng/mg protein/h) and of PGE (ampulla: 0-40 ± 0-05 and isthmus: 0-49 ± 0-07 ng/mg protein/h) in the medium (Harper, Coons, Radicke, Hodgson & Valenzuela, 1979;Harper, 1979).…”

Section: Discussionmentioning

confidence: 94%