Blood Flow Restriction: Cause for Optimism, But Let’s Not Abandon The Fundamentals

D, Lorenz

doi:10.26603/001c.23725

Cited by 1 publication

(1 citation statement)

References 46 publications

(24 reference statements)

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“…On the contrary, the BFR method is still a matter of controversy [ 72 , 73 , 74 ]. The variety in BFR devices leads to confusion about the restriction of blood flow with total arterial occlusion.…”

Section: Discussionmentioning

confidence: 99%

Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis—A Systematic Review with Meta-Analysis

Maga

Wachsmann-Maga

Batko³

et al. 2023

Biomedicines

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Despite growing evidence of the significant influence of blood-flow-restricted (BFR) training on different body functions, its impact on the vascular system, especially the arteries, is controversial. Therefore, the objective of our study was to analyze how BFR exercise, compared to other types of exercise without the restriction of blood flow, influences arterial functions and angiogenesis in adults. Studies comparing the effect of BFR versus non-BFR training on arterial parameters were divided into three categories: endothelial function, angiogenesis, and other vasculature functions. The search was based on Cochrane Library, PubMed®, and Embase, and 38 studies were included. The meta-analysis revealed a more significant improvement in flow-mediated dilatation (FMD) (p = 0.002) and the production of the primary angiogenesis biomarker vascular endothelial growth factor (VEGF) (p = 0.009) after BFR compared to non-BFR training (p = 0.002). The analysis of the pulse wave velocity, ankle-brachial index, systolic blood pressure, and heart rate did not show significant differences in changes between BFR and non-BFR training. The other parameters examined did not have sufficient data to be included in the meta-analysis. The results obtained present trends that suggest significant impacts of BFR training on endothelial functions and angiogenesis. There is still a lack of multicenter randomized clinical trials including many participants, and such studies are necessary to confirm the advantage of BFR over non-BFR activity.

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Section: Discussionmentioning

confidence: 99%