Blood flow rates through adipose tissues of unanesthetized rats

Ja, Herd; Hm, Goodman; Grose, SA

doi:10.1152/ajplegacy.1968.214.2.263

Cited by 36 publications

(15 citation statements)

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“…By 1 week to 10 days, however, he found a much better correlation, although brain DDT content was still conspicuously low. A comparable result was obtained in the rat by Herd et al (23), who demonstrated clearly that the initial (3 hr) distribution of 3H-DDT was a function of blood flow while the later (3 wk) distribution was in accord with lipid content.…”

Section: Discussionsupporting

confidence: 86%

Distribution, Metabolism, and Excretion of DDT and Mirex by a Marine Teleost, the Winter Flounder

Pritchard¹,

Guarino²,

Kinter³

1973

Environmental Health Perspectives

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Section: Discussionsupporting

confidence: 86%

Distribution, Metabolism, and Excretion of DDT and Mirex by a Marine Teleost, the Winter Flounder

Pritchard¹,

Guarino²,

Kinter³

1973

Environmental Health Perspectives

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“…The present finding that there is an increased blood flow in adipose tissue during active lipolysis is in agreement with several other current studies. Herd, Goodman & Grose (1968) estimated blood flow in five different fat depots in rats, using [3H]DDT as the indicator, and showed a correlation between blood flow and lipolysis. The highest blood flows were found in brown fat and the lowest in epigastric and epididymal fat.…”

Section: Discussionmentioning

confidence: 99%

The mechanism of functional vasodilatation in rabbit epigastric adipose tissue

Lewis¹,

Matthews²

1970

The Journal of Physiology

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1. The effect of close‐arterial infusions of fat‐mobilizing substances has been examined on the release of free fatty acids and blood flow in the epigastric adipose tissue of rabbits. 2. All the fat mobilizers in addition to causing the release of free fatty acids also caused an increased blood flow in the fat tissue. 3. Both the fat mobilization and the vasodilatation continued for an hour or so after the end of infusion. 4. Although no vasodilator substance could be detected in the venous effluent from the activated adipose tissue, a vasodilator could be detected in acid—ether extracts of adipose tissue excised during a period of fat mobilization. 5. It is suggested that a vasodilator substance is released or formed in adipose tissue during fat mobilization and that this substance accounts for the vasodilatation accompanying activity in the tissue.

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“…20 It has been shown that the blood flow rate through mesenteric adipose tissue is greater than the blood flow rate through inguinal subcutaneous adipose tissue in rats. 24 Also, we have reported that cardiac output in obese subjects, as estimated by echocardiography, was increased in proportion not only to body weight but also to the V/S ratio. 6 ' 25 These data suggest that the blood flow through adipose tissue in visceral fat obesity may be greater than in subcutaneous fat obesity for the same body weight.…”

Section: ±158mentioning

confidence: 94%

Close correlation of intra-abdominal fat accumulation to hypertension in obese women.

et al. 1990

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The relation between intra-abdominal visceral fat accumulation and blood pressure was investigated in 67 obese women (mean body mass index, 33.6±3.1; average age, 50±ll years). As an index of intra-abdominal fat accumulation, the ratio of the intra-abdominal visceral fat area to subcutaneous fat area was determined using a computed tomographic section at the level of the umbilicus. When the obese subjects were divided into a hypertensive group and a normotensive group, the ratio of the intra-abdominal visceral fat area to subcutaneous fat area in the hypertensive group was significantly higher (0.53±0.33 versus 0.29±0.12, p<0.01). Significant correlations between the ratio of intra-abdominal visceral fat area to subcutaneous fat area and systolic blood pressure (r=0.62, p< 0.001) and diastolic blood pressure (r=0.53, p< 0.001) also were found. However, no significant difference existed in either the body mass index or the waist-to-hip circumference ratio between the hypertensive and normotensive groups. Plasma renin activity, aldosterone, epinephrine, and norepinephrine levels were not significantly different between the two groups. Moreover, the correlation between the ratio of the intra-abdominal visceral fat area to subcutaneous fat area ratio and blood pressure was found independent of age and body mass index by multiple regression analyses. We conclude that intra-abdominal fat accumulation itself may play an important role in the pathogenesis of hypertension in obesity. (Hypertension 1990;16:484-490) I t has been noted that the incidence of circulatory and metabolic complications among comparably obese subjects differs depending on their body habitus.1 We have developed a method to estimate fat distribution using computed tomography (CT) scan, which clearly distinguishes between subcutaneous fat and intra-abdominal visceral fat 2 and have demonstrated a close correlation between intra-abdominal fat accumulation and metabolic disturbances.3 Further, using this method we reported that the accumulation of intra-abdominal visceral fat itself may reflect cardiac dysfunction and metabolic disorders better than subcutaneous fat. 4 -7 Therefore, we propose the existence of two types of obesity: visceral fat obesity, characterized by a pronounced accumulation of fat in the abdominal cavity, and subcutaneous fat obesity, From The Second Department of Internal Medicine, Osaka University Medical School, Fukushima-ku, Osaka, Japan.Presented in part at the 62nd Annual Scientific Sessions of the American Heart Association, New Orleans, Louisiana, November [13][14][15][16] 1989.Address for correspondence: Hideyuki Kanai, MD, The Second Department of Internal Medicine, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-ku, Osaka 553, Japan.Received March 7,199O, accepted in revised form June 15,1990. characterized by an accumulation mainly in the subcutis (Figure 1). We also reported 8 that this classification is more useful than other classifications of fat distribution, 9 "16 including the waist-to-hip circum...

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Blood flow rates through adipose tissues of unanesthetized rats

Cited by 36 publications

References 0 publications

Distribution, Metabolism, and Excretion of DDT and Mirex by a Marine Teleost, the Winter Flounder

Distribution, Metabolism, and Excretion of DDT and Mirex by a Marine Teleost, the Winter Flounder

The mechanism of functional vasodilatation in rabbit epigastric adipose tissue

Close correlation of intra-abdominal fat accumulation to hypertension in obese women.

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