Blood Flow Quantification with High-Frame-Rate, Contrast-Enhanced Ultrasound Velocimetry in Stented Aortoiliac Arteries: In Vivo Feasibility

Engelhard, Stefan; Helvert, Majorie van; Voorneveld, Jason; Bosch, Johan G.; Lajoinie, Guillaume; Jebbink, Erik Groot; Reijnen, Michel M.P.J.; Versluis, Michel

doi:10.1016/j.ultrasmedbio.2022.03.016

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…49,50 The feasibility of ePIV and CFD in patients with atherosclerosis has already been shown in small patient populations. 16,47,48,51,52 However, longitudinal studies with larger cohorts are necessary to show the potential benefit of these novel modalities in clinical practice and to study the relation between vector derived parameters and clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

“…An extra potential benefit of CFD models is the ability to predict the effect of different treatment strategies on local hemodynamics to select a treatment that creates an optimal hemodynamic environment, with the aim to reduce reintervention rates 49 , 50 . The feasibility of ePIV and CFD in patients with atherosclerosis has already been shown in small patient populations 16 , 47 , 48 , 51 , 52 . However, longitudinal studies with larger cohorts are necessary to show the potential benefit of these novel modalities in clinical practice and to study the relation between vector derived parameters and clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

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Validation of ultrasound velocimetry and computational fluid dynamics for flow assessment in femoral artery stenotic disease

van de Velde,

van Helvert,

Engelhard

et al. 2024

J. Med. Imag.

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To investigate the accuracy of high-framerate echo particle image velocimetry (ePIV) and computational fluid dynamics (CFD) for determining velocity vectors in femoral bifurcation models through comparison with optical particle image velocimetry (oPIV).Approach: Separate femoral bifurcation models were built for oPIV and ePIV measurements of a non-stenosed (control) and a 75%-area stenosed common femoral artery. A flow loop was used to create triphasic pulsatile flow. In-plane velocity vectors were measured with oPIV and ePIV. Flow was simulated with CFD using boundary conditions from ePIV and additional duplex-ultrasound (DUS) measurements. Mean differences and 95%-limits of agreement (1.96*SD) of the velocity magnitudes in space and time were compared, and the similarity of vector complexity (VC) and time-averaged wall shear stress (TAWSS) was assessed.Results: Similar flow features were observed between modalities with velocities up to 110 and 330 cm∕s in the control and the stenosed model, respectively. Relative to oPIV, ePIV and CFD-ePIV showed negligible mean differences in velocity (<3 cm∕s), with limits of agreement of AE25 cm∕s (control) and AE34 cm∕s (stenosed). CFD-DUS overestimated velocities with limits of agreements of 13 AE 40 and 16.1 AE 55 cm∕s for the control and stenosed model, respectively. VC showed good agreement, whereas TAWSS showed similar trends but with higher values for ePIV, CFD-DUS, and CFD-ePIV compared to oPIV.Conclusions: EPIV and CFD-ePIV can accurately measure complex flow features in the femoral bifurcation and around a stenosis. CFD-DUS showed larger deviations in velocities making it a less robust technique for hemodynamical assessment. The applied ePIV and CFD techniques enable two-and three-dimensional assessment of local hemodynamics with high spatiotemporal resolution and thereby overcome key limitations of current clinical modalities making them an attractive and cost-effective alternative for hemodynamical assessment in clinical practice.

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