Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps

Park, Marcelo; Mendes, Pedro Vitale; Hirota, Adriana Sayuri; Santos, E.; Costa, Eduardo Leite Vieira; Azevedo, Luciano César Pontes

doi:10.5935/0103-507x.20150030

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Blood decarboxylation depends on PFR/CO ratio [34] and sweep gas flow. At membrane entry, CO 2 partial pressure is zero and CO 2 removing gradient equals CO 2 venous partial pressure.…”

Section: Gas Exchanges Determinants During Va-ecmomentioning

confidence: 99%

Veno-arterial-ECMO in the intensive care unit: From technical aspects to clinical practice

Gall

Follin

Cholley

et al. 2018

Anaesthesia Critical Care & Pain Medicine

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The use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) as a salvage therapy in cardiogenic shock is becoming of current practice. While VA-ECMO is potentially a life-saving technique, results are sometimes mitigated, emphasising the need for selecting the right indication in the right patient. This relies upon a clear definition of the individual therapeutic project, including the potential for recovery as well as the possible complications associated with VA-ECMO. To maximise the benefits of VA-ECMO, the basics of extracorporeal circulation should be perfectly understood since VA-ECMO can sometimes be detrimental. Hence, to be successful, VA-ECMO should be used by teams with sufficient experience and initiated after a thorough multidisciplinary discussion considering patient's medical history, pathology as well the anticipated evolution of the disease.

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“…Blood decarboxylation depends on PFR/CO ratio [34] and sweep gas flow. At membrane entry, CO 2 partial pressure is zero and CO 2 removing gradient equals CO 2 venous partial pressure.…”

Section: Gas Exchanges Determinants During Va-ecmomentioning

confidence: 99%

Veno-arterial-ECMO in the intensive care unit: From technical aspects to clinical practice

Gall

Follin

Cholley

et al. 2018

Anaesthesia Critical Care & Pain Medicine

View full text Add to dashboard Cite

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“…[1][2][3][4][5] A major limitation of the process, however, is that it introduces hemolysis (i.e. 13,14 The most practical and promising suggestion to date involves lowering the occlusion level of roller pumps, 3,4 a common extracorporeal circulation pump. [6][7][8][9][10][11] Although the main cause of this blood damage had already been ascertained to be the shear stresses exerted on the blood as it ows through the extracorporeal circuit, 7,8,11,12 few solutions have been proposed to mitigate the hemolytic activities of the external pumping circuit.…”

Section: Introductionmentioning

confidence: 99%

A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

et al. 2016

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The use of an external mechanical pump to sustain the circulation in a body, also known as extracorporeal circulation, is an integral part of many medical procedures such as hemodialysis and cardio-pulmonary bypass. However, the damage to red blood cells caused by the flow-induced shear stresses in the flow circuit has remained an intractable problem for many years, limiting the operational duration of extracorporeal circulation. In this study, near-superhydrophobic surfaces were investigated as a potential solution to mitigate the hemolysis of blood during extracorporeal pumping through the use of a proofof-concept flow circuit. It was found that the thin layer of air trapped by the near-superhydrophobic surface due to the Cassie-Baxter state reduced the wall shear stress exerted on the blood flow, resulting in a corresponding decrease in the rate of hemolysis. For blood that undergoes an oscillatory flow, this reduction in the hemolysis was shown to be directly related to the mean shear rate and shear rate amplitude of the flow.

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“…( 9 , 10 ) The instrumentation, surgical preparation, sepsis induction, and pulmonary injury were performed as previously described and published in this journal. ( 11 , 12 )…”

Section: Methodsmentioning

confidence: 99%

Factors associated with blood oxygen partial pressure and carbon dioxide partial pressure regulation during respiratory extracorporeal membrane oxygenation support: data from a swine model

Park¹,

Mendes²,

Costa³

et al. 2016

Revista Brasileira De Terapia Intensiva

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ObjectiveThe aim of this study was to explore the factors associated with blood oxygen partial pressure and carbon dioxide partial pressure.MethodsThe factors associated with oxygen - and carbon dioxide regulation were investigated in an apneic pig model under veno-venous extracorporeal membrane oxygenation support. A predefined sequence of blood and sweep flows was tested.ResultsOxygenation was mainly associated with extracorporeal membrane oxygenation blood flow (beta coefficient = 0.036mmHg/mL/min), cardiac output (beta coefficient = -11.970mmHg/L/min) and pulmonary shunting (beta coefficient = -0.232mmHg/%). Furthermore, the initial oxygen partial pressure and carbon dioxide partial pressure measurements were also associated with oxygenation, with beta coefficients of 0.160 and 0.442mmHg/mmHg, respectively. Carbon dioxide partial pressure was associated with cardiac output (beta coefficient = 3.578mmHg/L/min), sweep gas flow (beta coefficient = -2.635mmHg/L/min), temperature (beta coefficient = 4.514mmHg/ºC), initial pH (beta coefficient = -66.065mmHg/0.01 unit) and hemoglobin (beta coefficient = 6.635mmHg/g/dL).ConclusionIn conclusion, elevations in blood and sweep gas flows in an apneic veno-venous extracorporeal membrane oxygenation model resulted in an increase in oxygen partial pressure and a reduction in carbon dioxide partial pressure 2, respectively. Furthermore, without the possibility of causal inference, oxygen partial pressure was negatively associated with pulmonary shunting and cardiac output, and carbon dioxide partial pressure was positively associated with cardiac output, core temperature and initial hemoglobin.

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Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps

Cited by 6 publications

References 19 publications

Veno-arterial-ECMO in the intensive care unit: From technical aspects to clinical practice

Veno-arterial-ECMO in the intensive care unit: From technical aspects to clinical practice

A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

Factors associated with blood oxygen partial pressure and carbon dioxide partial pressure regulation during respiratory extracorporeal membrane oxygenation support: data from a swine model

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