Blood Flow, Pressure and Compliance in the Male Human Bladder

Abstract

Human bladder blood flow tends to increase with increasing volume and pressure, and depends largely on local regulation. At capacity bladder blood flow is significantly decreased. Immediately after bladder drainage there is a rebound in blood flow, allowing reperfusion to occur. Decreased bladder blood flow and decreased bladder wall compliance correlated strongly, suggesting that ischemia may lead to structural changes in the bladder wall.

Translational Research and Functional Changes in Voiding Function in Older Adults

“…Histological studies have shown fibrosis formation or denervation in the bladder samples from elderly male and female patients without BOO 104–106 . These observations were supported by the study of Kershen et al (2002) which showed that decreased bladder blood flow and decreased bladder wall compliance correlated strongly, suggesting structural changes in the bladder wall induced by ischemia 107 . Moreover, pelvic arterial insufficiency such as caused by atherosclerosis, is also strongly associated with erectile dysfunction (ED) 108, 109 .…”

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“…First, the bladder wall is not merely a membrane that transfers pressure from the intra-abdominal space to the bladder content. Bladder wall compliance differs between patients and depends on several factors like age, BMI, filling status and bladder perfusion/ischemia [11]. Second, IAP reflects the relationship between the intra-abdominal volume and abdominal compliance.…”

Obstruction-induced alterations within the urinary bladder and their role in the pathophysiology of lower urinary tract symptomatology.

“…37 Moreover, the significantly reduced detrusor blood flow in both full and empty bladder states was also demonstrated by Doppler ultrasonography in patients with BOO. 38 Contrary to these findings, previous publications reported either inconsistent variations in blood flow during BOO 39 or increased blood flow with increasing volume and pressure; 40 however, these studies were either experimental (not performed on human bladders) or reporting results from early and/or very mild phases of obstruction.…”