Blood Flow in the Human Iris Measured by Laser Doppler Flowmetry

Chamot, Stéphane R.; Movaffaghy, Armand; Petrig, Benno L.; Riva, Charles E.

doi:10.1006/mvre.1998.2136

Cited by 14 publications

(14 citation statements)

References 17 publications

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“…12 This approach allowed us to determine changes in blood volume per unit area. Blood flow was assessed in the iris (anterior segment) and fundus (posterior segment) and the values in sham and BCCAO groups were compared.…”

Section: Monitoring Of Ocular Blood Flowmentioning

confidence: 99%

Bilateral Common Carotid Artery Occlusion in the Rat as a Model of Retinal Ischaemia

Huang

Fan

et al. 2014

Neuro-Ophthalmology

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Ocular ischaemic syndrome is a devastating eye disease caused by severe carotid artery stenosis. The purpose of the study was to develop a reliable rat model for this syndrome by means of common carotid artery occlusion and a controllable needle suture method. Adult Wistar rats were subjected to common carotid artery occlusion and sham surgery. The common carotid artery was ligated unilaterally or bilaterally with needles of different diameters, and ocular arterial filling time was examined by fluorescein fundus angiography at different time points. Haematoxylin-eosin staining of vessels and degree of stenosis were considered outcome measures. The ocular blood flow was monitored and measured by laser doppler flowmetry. Needles with a diameter of 0.4 mm were more effective in developing severe stenosis of the common carotid arteries compared with needles of other diameters. Bilateral common carotid artery occlusion was a more effective model than unilateral occlusion. The arterial filling time was significantly increased at 14 and 21 days after ligation (5.75 ± 0.45 and 6.27 ± 0.95 s, respectively) compared with arterial filling time before surgery (5.22 ± 0.64 s). The total blood flow in the sham surgery group was significantly higher than in the bilateral common carotid artery occlusion group. The fundus blood flow was statistically different between the two groups, whereas that of the anterior segment was not. In conclusion, the authors have established a rat model of ocular ischaemic syndrome via a controllable needle suture method, which was reliable up to 2-3 weeks after surgery.

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Section: Monitoring Of Ocular Blood Flowmentioning

confidence: 99%

Bilateral Common Carotid Artery Occlusion in the Rat as a Model of Retinal Ischaemia

Huang

Fan

et al. 2014

Neuro-Ophthalmology

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“…1992,1982; Petrig & Riva 1999), subfoveal choroid (Riva et al. 1994a, 1994b) and iris (Chamot et al. 1999).…”

Section: Basic Technologymentioning

confidence: 99%

“…For F ch , either with the camera‐based system or with the confocal system, the patient is asked to look directly at the probing beam. To perform measurements of F iris , the red laser beam mounted on a slit lamp is aimed at a small area of the tissue while the patient is fixating a point‐like target (Chamot et al. 1999).…”

Section: Clinical Protocolmentioning

confidence: 99%

Ocular blood flow assessment using continuous laser Doppler flowmetry

Riva

Geiser

Petrig

2010

Acta Ophthalmologica

113

101

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Acta Ophthalmol. 2010: 88: 622–629 Abstract. This article describes the technique of continuous laser Doppler flowmetry (LDF) as applied to the measurement of the flux of red blood cells in the optic nerve head, iris and subfoveal choroid. Starting with the exposition of the physical principles underlying LDF, we first describe the various devices developed to perform LDF in these vascular beds. We then discuss the clinical protocols, blood flow parameters, calibration procedures, reproducibility and limitations of the LDF technique. Various problems still need to be solved in order to bring to light the full potential of LDF in the assessment of microcirculatory haemodynamics.

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“…As described in detail in a previous paper (Chamot et al, 1999), LDF measurements were performed with 0014-4835\00\010107j06 $35.00\0…”

Section: Laser Doppler Flowmetry (Ldf ) Of the Irismentioning

confidence: 99%

Iris Blood Flow Response to Acute Decreases in Ocular Perfusion Pressure: A Laser Doppler Flowmetry Study in Humans

Chamot

Movaffaghy

Petrig

et al. 2000

Experimental Eye Research

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Blood Flow in the Human Iris Measured by Laser Doppler Flowmetry

Cited by 14 publications

References 17 publications

Bilateral Common Carotid Artery Occlusion in the Rat as a Model of Retinal Ischaemia

Bilateral Common Carotid Artery Occlusion in the Rat as a Model of Retinal Ischaemia

Ocular blood flow assessment using continuous laser Doppler flowmetry

Iris Blood Flow Response to Acute Decreases in Ocular Perfusion Pressure: A Laser Doppler Flowmetry Study in Humans

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