Blood flow in the cerebral cortex during cardiac resuscitation in dogs

Assessment of In-Hospital Cardiopulmonary Resuscitation Using Utstein Template in a University Hospital

“…Resuscitation time is considered to reflect the severity of ischemic injuries before and during CPR. Some investigators have estimated that, when CPR is begun immediately, cerebral blood flow is 3-15% of normal (Koehler et al 1963;Luce et al 1983;Jackson et al 1984) but decreases progressively as CPR continues (Sharaff et al 1984) and intracranial pressures rise (Guerci et al 1981;Bircher and Safar 1984). Nevertheless, acceptable neurological recovery has been reported even after prolonged CPR (Krug 1986).…”

The Use of High-Dose Epinephrine for Patients With Out-of-Hospital Cardiopulmonary Arrest Refractory to Prehospital Interventions

“…24 These studies have shown significant increases in regional myocardial blood flow, aortic diastolic pressure, cerebral blood flow, and ROSC in animals receiving 0.1 to 0.2 mg/kg as compared with those receiving 0.01 mg/kg of epinephrine. 22,[25][26][27][28][29] Furthermore, 2 series of pediatric inpatients experienced an improved rate of ROSC after receiving 0.2 mg/kg of epinephrine as the third dose during resuscitation. 4,30 However, there have been no large prospective clinical trials that established the effectiveness of HDE in cardiopulmonary arrest (CPA) of the pediatric patient.…”

Conjunctival oxygen monitoring during cardiopulmonary resuscitation.

“…Jackson et al (1984) reported cortical CBF in dogs in cardiac arrest with closed CPR to be 9-8% of pre-arrest flow, and continued to fall with increasing time from arrest to initiation of CPR and with prolonged CPR. The use of high (0-2 mg/kg/min) dose adrenaline in swine after 10 min CPR increased CBF from 7 to 13 ml/min/lOOg to the cortex and> 29 ml/min/1OOg to caudal CNS structures (Brown et al, 1986).…”