Blood Flow Dynamics in Cerebral Aneurysm - A CFD Simulation

Shishir, Shamiul Sarkar; Miah, Md. Abdul Karim; Islam, Ariful; Hasan, A. B. M. Toufique

doi:10.1016/j.proeng.2015.05.116

Cited by 15 publications

(14 citation statements)

References 15 publications

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“…These focused channels of flow could increase the risks of coil compaction and subsequent recanalization [27] [28]. Granted, Models 1 and 3 had similar reduction percentages and followed previous trends that fluid velocity increases with aneurysm entrance size [12].…”

Section: Resultssupporting

confidence: 67%

“…Fluid entered at a steady rate which does not reflect the pulsatile nature of blood flow, however, this is a common simulation setting in CFD simulations of intracranial aneurysms [12][13][14]. A polyhedral mesh was generated within a commercially available CFD software for each of the models.…”

Section: Fluid Modelmentioning

confidence: 99%

“…Simulated fluid was treated as an incompressible, Newtonian fluid, which has been shown to mimic the behavior of blood. Treating blood as a Newtonian fluid is a reasonable estimation in the vessel sizes used in this simulation [12] [14][15][16][17][18]. Fluid enters the model through a velocity inlet at a steady rate of 0.5 m/s and exits through a flow split outlet [19].…”

Section: Fluid Modelmentioning

confidence: 99%

“…Typical vessel sizes and past CFD simulations were considered when deciding on vessel diameters and idealized geometries used in this study [12][16] [20][21]. Models were constructed similarly in a commercially available CAD software.…”

Section: Vessel Representationmentioning

confidence: 99%

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Simulating Coil Embolization Treatments of Intracranial Aneurysms Using Computational Fluid Dynamics

Tulshibagwale

Gent

2019

2019 Design of Medical Devices Conference

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In this study, a commercially available computational fluid dynamics (CFD) program was used to simulate coil embolization techniques, standard coiling (SC) and stent-assisted coiling (SAC), in simplified vessels that are representative of vessels found in the brain. The test models included a curved vessel, ranging from 3mm to 4mm in diameter. The vessel was afflicted with a spherical aneurysm, ranging from 8mm to 16mm in diameter. The four test cases were simulated without treatment, with SC treatment, and with SAC treatment, for a total of twelve simulations. The parameters of interest were blood volume flow into aneurysm, fluid velocity, wall shear stress (WSS), and vorticity. Results of the simulations indicate, on average, SC and SAC reduced volume flow into the aneurysm by 50% and to over 60%, respectively. Both SC and SAC appeared to reduce distal neck WSS. Both treatments reduced average overall dome WSS by approximately 76%. Average aneurysm neck velocity was reduced by both treatments; SC reduced neck velocity by 69% and SAC reduced neck velocity by 75%. Information on SC and SAC efficacy in idealized scenarios could assist medical professionals determining viable approaches for patient-specific cases and lays foundation for future CFD studies exploring coil embolization treatments.

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Section: Resultssupporting

confidence: 67%

Section: Fluid Modelmentioning

confidence: 99%

Section: Fluid Modelmentioning

confidence: 99%

Section: Vessel Representationmentioning

confidence: 99%

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Simulating Coil Embolization Treatments of Intracranial Aneurysms Using Computational Fluid Dynamics

Tulshibagwale

Gent

2019

2019 Design of Medical Devices Conference

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“…Although blood is non-Newtonian, it is often treated as an incompressible Newtonian fluid (e.g., [18,19,[33][34][35][36]). Since the focus of this work is on the basic understanding of the effect of aneurysm size and softness rather than making accurate predictions, we model blood as a homogeneous Newtonian fluid with constant dynamic viscosity η.…”

Section: Physical Ingredientsmentioning

confidence: 99%

Effects of size and elasticity on the relation between flow velocity and wall shear stress in side-wall aneurysms: A lattice Boltzmann-based computer simulation study

Wang

Varnik

2019

Preprint

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Blood flow in an artery is a fluid-structure interaction problem. It is widely accepted that aneurysm formation, enlargement and failure are associated with wall shear stress (WSS) which is exerted by flowing blood on the aneurysmal wall. To date, most of the computational studies of this problem assume rigid walls. In particular, in the case of side-wall aneurysms, the combined effect of aneurysm size and wall elasticity on intra-aneurysm (IA) flow characteristics is poorly understood. Here we propose a model of three-dimensional viscous flow in a compliant artery containing an aneurysm by employing the immersed boundarylattice Boltzmann-finite element method. This model allows to adequately account for the elastic deformation of both the blood vessel and aneurysm walls. Using this model, we perform a detailed investigation of the flow through aneurysm under different conditions with a focus on the parameters which may influence the wall shear stress. Most importantly, it is shown in this work that the use of flow velocity as a proxy for wall shear stress is well justified only in those sections of the vessel which are close to the ideal cylindrical geometry. Within the aneurysm domain, however, the correlation between wall shear stress and flow velocity is largely lost due to the complexity of the geometry and the resulting flow pattern. Moreover, the correlations weaken further with the phase shift between flow velocity and transmural pressure. These findings have important implications for medical applications since wall shear stress is believed to play a crucial role in aneurysm rupture.

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