Blood fibrinogen levels discriminate low- and high risk intraductal papillary mucinous neoplasms (IPMNs)

Nentwich, Michael F.; Menzel, Karsten; Reeh, M.; Uzunoğlu, Faik G.; Ghadban, Tarik; Bachmann, Kai; Schrader, Jörg; Bockhorn, Maximillian; Izbicki, Jakob R.; Pérez, Daniel Rodríguez

doi:10.1016/j.hpb.2019.10.519

Cited by 2 publications

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“…The role of the biomarkers of coagulation activity in patients with pathologic fractures has not previously been studied. In the study by Mattila et al on biomarkers of coagulation in pancreatic tumors, the preoperative acute phase reactants fibrinogen and FVIII distinguished cancer from benign tumors [17,18,20]. Our data on pathological fractures showed that these coagulation biomarker levels are significantly increased in all patients.…”

Section: Discussionsupporting

confidence: 48%

“…FVIII, fibrinogen, and D-dimer have recently all been reported to improve diagnostics and aid surgical decision-making in pancreatic [17][18][19] and gynaecological cancers [20]. Therefore we aimed at identifying associations between coagulation biomarkers and postoperative thromboembolic complications and survival in patients who had undergone surgery for non-spinal actual or impending pathologic fractures.…”

Section: Introductionmentioning

confidence: 99%

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Preoperative coagulation biomarkers associate with survival and pulmonary embolism after surgical treatment of non-spinal skeletal metastases

et al. 2022

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Background Thrombotic complications are synergistic and associated with orthopedic procedures, trauma, and malignancy. Because cancer enhances coagulation activity and vice versa, we assessed preoperative biomarkers for survival and complications after treatment of pathologic fractures in non-spinal skeletal metastases. Patients/methods Our study population comprised 113 actual or impending pathologic fractures in 100 patients admitted to two referral centers. Laboratory variables were collected retrospectively from patient records and analyzed related to incidence of pulmonary embolism (PE) and mortality (Kaplan-Meier and Cox regression analyses and biomarker quartiles). Results Preoperative coagulation variables were high without exceptions. PE occurred in 12 patients at 36 post-operative days at incidence of 11% in the lower and 13% in the upper extremity fractures. Patients with fibrinogen exceeding 5 g/l (log-rank 0.022) developed PE earlier (5 to 15 days postoperatively) than others. Also, mean patient survival with normal fibrinogen range (2–4 g/l) was 34 months, whereas it halved upon elevated fibrinogen (log-rank p = 0.009). Survival in patients with FVIII levels under 326 IU/dl (Q3) was 22 months, but only 7 months if FVIII exceeded 326 IU/dl (log-rank p = 0.002). Combined elevated fibrinogen and FVIII predicted survival: for patients with levels below threshold limits was 22 months versus only 7 months when both variables exceeded the ranges (log-rank p < 0.001). Multivariate analysis to control confounders supported an independent role of fibrinogen and FVIII for survival. Conclusions Our study has established fibrinogen and FVIII as potential preoperative contributors of survival and complications after treatment of metastatic fractures. These results highlight the need for novel anticoagulation and thromboprophylaxis strategies among these patients.

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Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Preoperative coagulation biomarkers associate with survival and pulmonary embolism after surgical treatment of non-spinal skeletal metastases

et al. 2022

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“…Numerous previous studies have discovered that the coagulation system is overly activated in many cancers, such as lung cancer [8,9], hepatocellular carcinoma [10,11], pancreatic cancer [12], and oesophageal cancer [13,14] and so on, but data about cancers of the urinary system, especially renal cell carcinoma, are still lacking. Jun Du [15] enrolled 286 patients receiving radical nephrectomy and retrospectively evaluated the association of preoperative plasma fibrinogen level with the clinicopathological parameters and survival.…”

Section: Discussionmentioning

confidence: 99%

High Preoperative Plasma Fibrinogen Independently Predicts a Poor Prognosis in Patients with Nonmetastatic RCC

et al. 2020

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Background: This study aims to determine the relationship between preoperative plasma fibrinogen levels and the prognosis of patients with nonmetastatic renal cell carcinoma (RCC), including overall survival (OS), cancer-specific survival (CSS) and progression-free survival (PFS). Methods: We retrospectively analysed the clinical data and prognostic information of 1194 nonmetastatic RCC patients who received radical nephrectomy or nephron-sparing surgery between 2005 and 2015 at our institution. Serum was collected for fibrinogen detection in the week prior to curative operation, and prognostic information was regularly collected by specially trained personnel. The cutoff value of the preoperative plasma fibrinogen level was defined by receiver operating characteristic (ROC) analysis. The chi-square test was used to analyse the association between preoperative fibrinogen level and clinical characteristics. Kaplan-Meier analysis was used to calculate survival curves, and significant differences were determined by the log-rank test. Other significant prognostic factors were evaluated by the Cox multivariate proportional hazard model. Results: The median follow-up period after radical or partial nephrectomy was 42.4 months (ranging from 0.433 to 146.37 months). The optimal preoperative plasma fibrinogen concentration was 3.975 g/L. The preoperative fibrinogen level was significantly associated with age, pathological T stage, sarcomatoid differentiation, necrosis and vein tumour thrombus (all p<0.05). High plasma fibrinogen levels were related to poor prognosis in terms of OS (p<0.001), CSS (p<0.001) and PFS (p<0.001). Multivariate analysis showed that the preoperative fibrinogen level remained an independent prognostic factor for OS (HR: 3.22, 95%CI: 1.87-5.55, p<0.001), CSS (HR: 4.12, 95%: 2.15-7.89, p<0.001) and PFS (HR: 3.137, 95%CI: 2.17-4.53, p<0.001). Conclusions: High preoperative plasma fibrinogen level is an independent negative prognostic factor for OS, CSS and PFS in patients with non-metastatic RCC. Preoperative plasma fibrinogen could be an ideal indicator for evaluating the outcomes of postoperative patients with nonmetastatic RCC.

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Blood fibrinogen levels discriminate low- and high risk intraductal papillary mucinous neoplasms (IPMNs)

Cited by 2 publications

References 0 publications

Preoperative coagulation biomarkers associate with survival and pulmonary embolism after surgical treatment of non-spinal skeletal metastases

Preoperative coagulation biomarkers associate with survival and pulmonary embolism after surgical treatment of non-spinal skeletal metastases

High Preoperative Plasma Fibrinogen Independently Predicts a Poor Prognosis in Patients with Nonmetastatic RCC

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