Blood donor eligibility criteria for medical conditions: A <scp>BEST</scp> collaborative study

Jacquot, Cyril; Tiberghien, Pierre; Hurk, Katja van den; Ziman, Alyssa; Shaz, Beth H.; Apelseth, Torunn Oveland; Goldman, Mindy

doi:10.1111/vox.13281

Cited by 6 publications

(9 citation statements)

References 16 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deferral policies for donors with diabetes vary considerably, partly because of the lack of published studies addressing safety concerns [2]. Most US blood centres accept all donors with diabetes, and eligibility is not covered by the US Food and Drug administration (FDA) guidance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evolving policies for donors with diabetes: The Canadian experience

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background and Objectives Donor criteria for diabetes vary significantly. We describe our evolving policies for donors with diabetes, their contribution to the Canadian blood supply and their rate of syncopal reactions compared to other donors. Materials and Methods All donors are asked if they have diabetes and have taken medications in the last 3 days. We assessed donors with diabetes on various medications, the number deferred over time, and syncopal reactions in donors with diabetes and other donors in our donor reaction database. Results Policy changes allowing type 2 diabetic donors on oral hypoglycaemics alone, type 2 diabetic donors on oral medications and insulin and type 1 diabetic donors (all on insulin) to donate resulted in a decrease in deferrals from 450 to 22 donors annually. Of donors being treated with medication for diabetes, 11% are receiving insulin as part of their treatment. Syncopal reaction rates were low and not statistically different between diabetic and non‐diabetic donors, although confidence intervals (CIs) are large. Conclusion Policies decreased deferrals while maintaining safety. A longer observation period would strengthen these observations.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Insulin may be added if glycaemic targets are not achieved [1]. Donor criteria for diabetes vary significantly among blood centres [2]. Donors with diabetes may be deferred for possible increased donor risk (syncopal or pre-syncopal reactions) and recipient risk (bacteraemia) [3].…”

Section: Introductionmentioning

confidence: 99%

Evolving policies for donors with diabetes: The Canadian experience

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Table 1 lists some common deferral categories. These may vary considerably in different countries, based on epidemiology of infectious agents and regulatory requirements 9 . In most countries, gay and bisexual men are deferred for a given period of time after having sex with another man although this is changing.…”

Section: Donor Selection Criteriamentioning

confidence: 99%

“…These may vary considerably in different countries, based on epidemiology of infectious agents and regulatory requirements. 9 In most countries, gay and bisexual men are deferred for a given period of time after having sex with another man although this is changing. In general, European regulations, based on the EU directive of 2004 are more stringent regarding deferrals for medical conditions, while these conditions are not covered in US FDA regulations, resulting in more liberal practices.…”

Section: Donor Selection Criteriamentioning

confidence: 99%

How do we decide how representative our donors are for public health surveillance?

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Surveillance of blood donors is fundamental to safety of the blood supply. Such data can also be useful for public health policy but tend to be underutilized. When the COVID‐19 pandemic arrived, blood centers around the world measured blood donor SARS‐CoV‐2 seroprevalence to inform public health policy. There is now a movement toward blood centers becoming more involved in public health research and surveillance post‐pandemic. However, blood donors are a healthy population and not representative of all segments of the general population. In this article, we explain how blood centers can evaluate their donor base to understand which part of the general population they are representative of. Study Design and Methods Methodologic approaches for evaluating samples relative to the target population were reviewed. Blood donor data that are available to most blood centers were identified and application to assess representativeness of blood donors was evaluated. Results Key aspects of blood donor data to compare with general population data include donor selection criteria, health indicators, geography, and demographics. In some cases, statistical adjustment can improve representativeness. Discussion Comparing key blood donor data with corresponding general population data can define the subset of the general population for which a particular blood center's donors may be representative of. We suggest that donors are an ideal convenience population for surveillance of infectious agents which are frequently asymptomatic and main routes of transmission are not deferrable, for studying the natural history of disease in an initially well population, and for vaccination serology surveillance.

show abstract

“…Assessment of medication use and determination of eligibility criteria for donors on medications varies widely among blood centres [1,2].…”

Section: Introductionmentioning

confidence: 99%

Medication use in Canadian blood donors

2022

Self Cite

View full text Add to dashboard Cite

Background and Objectives: Policies regarding medication use vary between blood centres. We evaluated medication use in eligible Canadian Blood Services whole blood donors to inform possible process improvements and allow comparisons between donors and the general population. Materials and Methods: All donors are asked about medication use in the last 3 days, and medications and their reason for use are documented in our donor computer system. Donor computer records were reviewed from January 1, 2020, to March 31, 2022 to extract information on medications by donor age and sex; medications were grouped into therapeutic classes. Stability of medication use over time was determined in a random sample of 100 donors who made at least two donations in the study period. Results: One-third of successful (eligible) donors were taking medications; of these, 80% were on one or two medications. Five classes of medication accounted for 72% of medication use, and 13 classes account for 93% of use. Use remains relatively stable over time. Conclusion: Medication use is common, with a few classes accounting for most use. Drop-down lists and storage of information from one donation to the next may enhance efficiency.

show abstract

Blood donor eligibility criteria for medical conditions: A BEST collaborative study

Cited by 6 publications

References 16 publications

Evolving policies for donors with diabetes: The Canadian experience

Evolving policies for donors with diabetes: The Canadian experience

How do we decide how representative our donors are for public health surveillance?

Medication use in Canadian blood donors

Contact Info

Product

Resources

About