Blood-derived topical therapy for ocular surface diseases

Soni, Nishant; Jeng, Bennie H.

doi:10.1136/bjophthalmol-2015-306842

Cited by 63 publications

(52 citation statements)

References 71 publications

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“…Improvement of tear film break-up time and Schirmer tear test results have been observed in the study population [Selek et al, 2000]. Human serum and plasma-derived products such as autologous serum eye drops and autologous platelet-rich plasma (PRP) have been demonstrated to be beneficial in PEDs and dry eye disease [Jeng and Dupps, 2009;Hussain et al, 2014;Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. Thus, tretinoin maybe the secondary option for the treatment of SM-induced dry eye.…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 93%

“…However, tretinoin did not improve ocular symptoms such as photophobia and foreign body sensation [Selek et al, 2000]. About 50% autologous serum eye drops have been documented to be safe and effective for the management of corneal defects, because the serum composition is similar to the tear, with the presence of epidermal growth factor (EGF) and transforming growth factor-b (TGF-b), leading to regenerative process and healing of corneal defects [Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. The efficacy of 0.01% all-transretinoic acid is documented for the treatment of myopia and corneal epithelial erosions [Ubels et al, 1985;Huang et al, 2011].…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

“…Human serum and plasma-derived products such as autologous serum eye drops and autologous platelet-rich plasma (PRP) have been demonstrated to be beneficial in PEDs and dry eye disease [Jeng and Dupps, 2009;Hussain et al, 2014;Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. About 50% autologous serum eye drops have been documented to be safe and effective for the management of corneal defects, because the serum composition is similar to the tear, with the presence of epidermal growth factor (EGF) and transforming growth factor-b (TGF-b), leading to regenerative process and healing of corneal defects [Alio et al, 2015;Tseng et al, 2015;Soni and Jeng, 2016]. PRP contains more EGF and TGF-b than 50% autologous serum and is showed to be more efficient with a higher cure rate compared to 50% autologous serum in patients with PEDs [Kim et al, 2012].…”

Section: Medical Managementsmentioning

confidence: 99%

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Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes, and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis, and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain. Corneal abrasions, ulcerations, vesication, and perforations are common corneal consequences in SM injured victims. Appearance of chronic symptoms has been reported as chronic inflammation of the corneal and conjunctival vasculature, ischemia, lipid and cholesterol deposition, scarring in cornea, corneal thinning, opacification and perforation of the cornea, limbal stem cell deficiency (LSCD), and neovascularization. Different medical and surgical protocols have been documented in the management of SM-induced ocular injuries, including preservative-free artificial tears, topical steroids and antibiotic, mydriatic, antiglaucoma drops, therapeutic contact lenses, dark glasses and punctal plugs/cauterization, N-acetylcysteine, tarsorrhaphy, amniotic membrane transplantation, stem cell transplantation, and corneal transplantation. New drugs such as resolvin E1, topical form of essential fatty acids, thymosin β4, 43 amino-acid polypeptides, topical form of curcumin, newly formulated artificial tears, diquafosol, rebamipide, tretinoin, and oral uridineseems to be beneficial in the management of ocular lesion associated with sulfur mustard poisoning. Further studies are needed to approve these drugs in SM victims. J. Cell. Biochem. 118: 3549-3560, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 93%

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

Section: Medical Managementsmentioning

confidence: 99%

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Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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“…58 The detailed protocol and guidelines for the preparation of AST, allowing its widespread use was presented by Tsubota et al 59 Although a concentration of 20% is most commonly used, no standardization and RCTs have been performed to determine the optimal concentration, frequency, and duration of therapy. 60 Numerous studies have, however, reported the efficacy of AST in DED, demonstrating improvement in ocular discomfort and corneal staining 61–67 Noble et al demonstrated in a crossover RCT significant improvement in DED symptoms with 50% AST compared to conventional therapy. 68 Further, Kojima et al showed significant improvement in signs and symptoms with AST compared to preservative-free artificial tears in a RCT.…”

Section: Management Of Patients With Neuropathic Corneal Painmentioning

confidence: 99%

Neuropathic Corneal Pain

2017

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Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined disease. Patients with NCP are extremely challenging to manage and evidence-based clinical recommendations for the management of patients with NCP are scarce. The objectives of this review are to provide guidelines for diagnosis and treatment of patients with NCP and to summarize current evidence-based literature in this area. We performed a systematic literature search of all relevant publications between 1966 and 2017. Treatment recommendations are, in part, based on methodologically sound randomized controlled trials (RCTs), demonstrating superiority to placebo or relevant control treatments, and on the consistency of evidence, degree of efficacy, and safety. In addition, the recommendations include our own extensive experience in the management of these patients over the past decade. A comprehensive algorithm, based on clinical evaluation and complementary tests, is presented for diagnosis and subcategorization of patients with NCP. Recommended first-line topical treatments include neuro-regenerative and anti-inflammatory agents, whilst first-line systemic pharmacotherapy includes tricyclic antidepressants and the anticonvulsant. Second line oral treatments recommended include the opioid-antagonist and opiate analgesics. Complementary and alternative treatments, such as cardio-exercise, acupuncture, omega-3 fatty acid, and gluten-free diet, may have additional benefits, as do potential non-invasive and invasive procedures in recalcitrant cases. Medication selection should be tailored on an individual basis, considering side effects, comorbidities, and levels of peripheral and centralized pain. Nevertheless, there is an urgent need for long-term studies and RCTs assessing the efficacy of treatments for NCP.

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“…Creation of a whole limbal niche is under investigation by tissue engineering approaches [22]. Applying anti-inflammatory tissues like amniotic membrane and its derivatives [9•], blood-derived products [57], and growth factors [58] have revealed significant results in experimental studies. One novel method which has shown promising results is the application of mesenchymal stem cells (MSCs) and/or their trophic factors [32•].…”

Section: Therapeutic Approaches: Restoring the Limbal Niche As A Prommentioning

confidence: 99%

Limbal and corneal epithelial homeostasis

Yazdanpanah

Jabbehdari²,

Djalilian

2017

Current Opinion in Ophthalmology

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Purpose of Review The aim of this review is to describe the underlying mechanisms of corneal epithelial homeostasis in addition to illustrating the vital role of the limbal epithelial stem cells (LESCs) and the limbal niche in epithelial regeneration and wound healing. Recent Findings The shedded corneal epithelial cells are constantly replenished by the LESCs which give rise to epithelial cells that proliferate, differentiate and migrate centripetally. While some recent studies have proposed that epithelial stem cells may also be present in the central cornea, the predominant location for the stem cells is the limbus. The limbal niche is the specialized micro-environment consisting of cells, extra-cellular matrix and signaling molecules that are essential for the function of LESCs. Disturbances to limbal niche can result in LESC dysfunction, therefore, limbal stem cell deficiency should also be considered a limbal niche deficiency. Current and in–development therapeutic strategies are aimed at restoring the limbal niche, by medical and/or surgical treatments, administration of trophic factors and cell based therapies. Summary The corneal epithelium is constantly replenished by LESCs that are housed within the limbal niche. The limbal niche is the primary determinant of the LESC function and novel therapeutic approaches should be focused on regeneration of this microenvironment.

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Blood-derived topical therapy for ocular surface diseases

Cited by 63 publications

References 71 publications

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Neuropathic Corneal Pain

Limbal and corneal epithelial homeostasis

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