Blood-derived immunoglobulins in milk replacer, or by injection, for improved performance of colostrum-deprived neonatal calves

Crowley, M.L.; Fisher, L. J.; Owen, B. D.

doi:10.1016/0377-8401(94)90128-7

Cited by 7 publications

(7 citation statements)

References 17 publications

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“…Colostrum is vital to the health and survival of the neonatal calf, and 18% of dairy cows provide colostrum yields containing less than 100 g of IgG, the most commonly recommended amount to prevent failure of passive transfer (FPT) (Levieux and Ollier, 1999). Colostrum-deprived calves are 50 to 75 times more likely to die before 21 d of age than colostrum-fed calves, with most deaths occurring during the first week of life (Smith and Little, 1922;Crowley et al, 1994;Wells et al, 1996). Therefore, colostrum supplements (CS) and colostrum replacers (CR) can be provided when colostrum is either of poor quality or unavailable.…”

Section: Introductionmentioning

confidence: 99%

Characterization of a Colostrum Replacer and a Colostrum Supplement Containing IgG Concentrate and Growth Factors

Hammer¹,

Quigley²,

Ribeiro³

et al. 2004

Journal of Dairy Science

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The objective of this study was to characterize absorption of colostrum replacer (CR) or supplement (CS) containing fractions of bovine plasma. Immunoglobulin concentrate (IGC) was prepared from bovine blood to a final purity of approximately 90% IgG. Blood was also processed to produce a fraction containing elevated concentrations of IGF-I and TGF-beta (GF). Both IGC and GF were spray-dried and blended with other ingredients to produce CR (30% IgG) or CS (15% IgG) containing 0 or 5% GF. Holstein bull calves were assigned to one of five treatments: 1) Pooled colostrum (MC)--1.9 L of pooled colostrum at 1 and 8 h of age to provide over 150 g of IgG; 2) Low supplement (LC)--1.9 L of CS at 1 and 8 h of age to provide 150 g of IgG; 3) Low supplement + GF (LG)--1.9 L of a CS with GF at 1 and 8 h of age to provide 150 g of IgG; 4) High supplement (HC)--1.9 L of CR at 1 h of age to provide 150 g of IgG and 1.9 L of a commercial milk replacer (MR) at 8 h of age; and 5) High supplement + GF (HG)--1.9 L of a CR with GF at 1 h of age to provide 150 g of IgG and 1.9 L of MR at 8 h of age. Apparent efficiency of IgG absorption was higher for calves fed HC and HG compared with those fed LC and LG and was lower for calves fed LG and HG compared with those fed LC and HC. IgG concentrations at 24 h were highest in calves fed MC compared with other calves and were higher in calves fed HC and HG compared to LC and LG. Calves fed LG and HG had lower IgG concentrations at 24 h of age compared with those fed LC and HC. These results indicate that 150 g of IgG provided in one dose soon after birth is superior to 150 g of IgG fed in two doses 7 h apart. Also, addition of a plasma fraction containing elevated concentrations of IGF-I and TGF-beta decreased IgG absorption in the neonatal calf.

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Section: Introductionmentioning

confidence: 99%

Characterization of a Colostrum Replacer and a Colostrum Supplement Containing IgG Concentrate and Growth Factors

Hammer¹,

Quigley²,

Ribeiro³

et al. 2004

Journal of Dairy Science

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“…Recognition of the economic importance of FPT in large animal neonates has led to the development of a number of colostrum replacements and immunoglobulin supplements for the prevention and treatment of FPT. [39][40][41][42][43][44][45][46][47][48][49] The route of administration for these supplements is dependent in part on the timing of administration relative to intestinal closure. Prior to intestinal closure, oral administration of these supplements to newborns at risk for FPT has resulted in serum IgG concentrations considered adequate for protection against infection.…”

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confidence: 99%

Use of adult cat serum to correct failure of passive transfer in kittens

Levy¹,

Crawford²,

Collante³

et al. 2001

javma

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“…In the first stages of life, when the capacity of producing endogenous antibodies is very limited, they are acquired from the maternal colostrum and milk (Lijnnerdal 1985;Williams 1993). However, in pathological conditions or in a precocious weaning, exogenous immunoglobulins, among other treatments are used to avoid and cure diseases (Crowley et al 1994). In veterinary medicine, the immunoglobulins are currently used to help animals survive the critical first weeks of life, where the largest animal loss is due to infections (Ewan 1989;Williams 1993).…”

Section: Introductionmentioning

confidence: 99%

“…In veterinary medicine, the immunoglobulins are currently used to help animals survive the critical first weeks of life, where the largest animal loss is due to infections (Ewan 1989;Williams 1993). For this purpose the immunoglobulins have been isolated from whey and blood (Hutchens et al 1990;Crowley et al 1994;Li-Chan el al. 1995).…”

Section: Introductionmentioning

confidence: 99%

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Scale Up Isolation of Immunoglobulins From Pig Serum by Immobilized Metal Affinity Chromatography

Vázquez–Moreno

Plata

1995

J Food Biochemistry

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The immunoglobulins (Ig s) are proteins with a well-known structure andfunction. In immunocompetent animals (individuals), these proteins counteract the pathogenic microorganisms. However, under pathological conditions or in a precocious weaning, exogenous immunoglobulins, among other treatments, are being used to avoid and cure some diseases. There is much interest in developing alternative methods for the isolation offunctional immunoglobulins from sources different than maternal colostrum and milk. Pig serum contains a high concentration of I g s and it has the advantage of containing not only IgG but also IgA and IgM in a greater proportion than found in any other species. Pig serum is a major contaminant generated by meat producers that could be used as a biotechnological alternative for blood or milk whey.Immunoglobulins G, A and M were isolatedfrom porcine serum using Nickel-Iminodiacetate-ephrose 6B in a single step at an analytical level. The procedure was easily scaled up to a 30 ml bed column. Serum immunoglobins (1 76 ml; 8.7 g ) were adsorbed to the gel in buffer, pH 6.0, containing 1.0 M NaCl, and the purij?ed immunoglobulins (735 mg) were eluted using the same buffer, but at pH 5.0. This separation was repeated 27 times without loss of gel capacity. The source of immunoglobulins, the longevity of the adsorbent, the gel capacity (29 m g h l bed volume) and the mild conditions allowed rapid isolation of high concentrations of immunoglobulins. This method can serve as an alternative to those currently available for obtaining the three major immunoglobulins for inclusion in animal feeding.

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Blood-derived immunoglobulins in milk replacer, or by injection, for improved performance of colostrum-deprived neonatal calves

Cited by 7 publications

References 17 publications

Characterization of a Colostrum Replacer and a Colostrum Supplement Containing IgG Concentrate and Growth Factors

Characterization of a Colostrum Replacer and a Colostrum Supplement Containing IgG Concentrate and Growth Factors

Use of adult cat serum to correct failure of passive transfer in kittens

Scale Up Isolation of Immunoglobulins From Pig Serum by Immobilized Metal Affinity Chromatography

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