Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function

Abstract

The phenotypic and migratory disturbances observed in SLE blood DCs could result in altered distribution of DCs in peripheral tissues, contributing to dysregulated immune responses and autoimmunity.

Unusual aetiology of isolated lower motor neuron facial palsy: systemic lupus erythematosus presenting with cranial nerve palsy and nephritis

“…However, it is plausible that her facial palsy is a manifestation of underlying SLE. One of the suggested pathophysiological mechanisms of SLE involve immune dysregulation with potential activation of the disease process by infections which may also be the trigger for CN VII palsy 7. Potential mechanisms for CN VII palsy in SLE include autoimmune antibodies against neuronal antigen or inflammatory cytokines; both of which may be triggered by an infectious process, viral or bacterial.…”

Tissue-resident dendritic cells and diseases involving dendritic cell malfunction

“…pDCs are capable of rapidly producing large amount of type-I IFNs 200–1000 times more than other immune cell types upon microbial challenge [ 100 ]. From SLE patients, the bone marrow-derived pDCs exhibited activated phenotypes with higher expression of CD40 and CD86 and induced stronger T-cell proliferation [ 101 ], reduced ChemR23 chemokine receptor expression and enhanced migratory ability of pDCs, which are suggestive of an activated status of pDCs in SLE patients [ 102 ]. Apart from directly augmenting the functions of autoreactive T and B cells, type I-IFN also acts indirectly through promoting the differentiation of blood-derived monocytes and activation of mDC, which then up-regulates MHC-II and co-stimulatory molecules for autoreactive helper (Th) and cytotoxic (TC) T cell activation; and enhances BAFF and APRIL expression for promoting autoreactive B cell survival and proliferation.…”

Efeito da adipocina chemerin na reabsorção ósseoa em modelo experimental de doença periodontal e hiperlipidemia

“…Crohn (Weigert et al, 2010), doença hepática não-alcólica (Kukla et al, 2010), doença desmielinizante autoimmune (Graham et al, 2009), lupus eritematoso (Gerl et al, 2010) e doença periodontal (Ozcan et al, 2014). Além disso, níveis séricos da adipocina chemerin estão aumentados em pacientes obesos Os modelos de obesidade que envolvem mudanças na dieta dos animais consistem em modificações da ração, seja enriquecida com gordura (high-fat), açúcares (high-sucrose) ou ambos (Naderali et al, 2001;Naderali et al, 2003).…”

“…Além disso, os níveis circulantes de chemerin estão aumentados em uma série de doenças, tais como colite ulcerativa e doença de Crohn (Weigert et al, 2010), doença hepática não-alcólica (Kukla et al, 2010), doença desmielinizante autoimmune (Graham et al, 2009) e lupus eritematoso (Gerl et al, 2010 in vitro e in vivo (Dang et al, 2002;Okazaki et al, 2002;Duque, Macoritto and Kremer, 2004).…”

“…Os níveis circulantes de chemerin estão aumentados em uma série de doenças (Graham et al, 2009;Weigert et al, 2010;Kukla et al, 2010;Gerl et al, 2010) e também, estão relacionados ao IMC (Bozaoglu et al, 2007;Stejskal et al, 2008;Dong et al, 2011). Por isso, com o objetivo de avaliar se a dieta hiperlipidêmica ou a infecção eram capazes de alterar os níveis de chemerin plasmático, foi determinado a concentração de chemerin em plasma sanguíneo nos animais dos diferentes grupos experimentais.…”