Blood Count-Derived Inflammatory Markers and Acute Complications of Ischemic Heart Disease in Elderly Women

Abstract

Coronary artery disease (CAD) in women occurs later than in men. Underlying atherosclerosis, a chronic process of lipoprotein deposition in arterial walls with a prominent inflammatory component, is influenced by several risk factors. In women, commonly used inflammatory markers are generally found to be related to the occurrence of acute coronary syndrome (ACS), as well as the development of other diseases that influence CAD. New inflammatory markers derived from total blood count—systemic inflammatory response index (SII), systemic inflammatory reaction index (SIRI), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR)—were analyzed in the group of 244 elderly, postmenopausal women with the diagnosis of ACS or stable CAD. SII, SIRI, MLR, and NLR were significantly higher in women with ACS compared to those with stable CAD (p < 0.05 for all)—the highest values were observed in women with NSTEMI. MLR from new inflammatory markers, HDL, and history of MI turned out to be significant factors associated with ACS. These results suggest that MLR as representative of blood count-derived inflammatory markers may be considered as additional CVD risk factors in women with suspected ACS.

Exploring the utility of a latent variable as comprehensive inflammatory prognostic index in critically ill patients with cerebral infarction

“…The disruption of normal coagulation processes after cerebral infarction can lead to exacerbated ischemic damage in the brain, and also activate multiple inflammatory pathways ( 35 ). The changes in peripheral blood indicators like neutrophils, lymphocytes, monocytes, and platelets are sensitive markers of the body’s cascade response to cerebral infarction, especially in the presence of severe complications and comorbidities ( 36 , 37 ). By conducting EFA on NLR, SIII, and SIRI, CIPI maintains their common features while enhancing their unique contributions.…”

The Prognostic Role of Platelet-to-Lymphocyte Ratio in Acute Coronary Syndromes: A Systematic Review and Meta-Analysis

“…After an initial screening of titles and abstracts, 43 articles were selected for assessment of full texts, resulting in a further exclusion of 24 studies. Finally, a total of 19 studies were eventually included in the review (Table 1) [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Five prospective and fourteen retrospective studies were published from 2015 to 2023, with sample sizes between 170 and 2230.…”

Peranan Rasio Monosit Terhadap Limfosit (Mlr) Sebagai Prediktor Kejadian Nstemi

“…Limfopenia pada kasus NSTEMI, tercermin dalam penelitian ini, dapat terjadi akibat produksi yang berkurang akibat peningkatan level steroid karena stres dan apoptosis yang meningkat akibat peradangan yang tinggi, yang mengakibatkan peningkatan MLR (Sharma et al, 2017). Penelitian sebelumnya menghubungan antara limfopenia dengan prognostik yang lebih buruk pada infark miokard (Dziedzic et al, 2023). Hal ini dapat terjadi karena limfosit memiliki peran dalam penyembuhan miokardium setelah infark, namun infark yang terjadi dapat mengaktivasi sinyal adrenergik dan meningkatkan produksi monosit yang menyebabkan terhambatnya penyembuhan miokardial dan meningkatkan risiko komplikasi miokardial (Quan et al, 2020).…”

“…Hasil ini sejalan dengan studi lain yang dilakukan oleh Dziedzic, dkk (2023) terhadap 244 perempuan menopause dengan menggunakan angiografi kateter. Penelitian tersebut menemukan sensitivitas dan spesifisitas MLR 0.574 (p-value = 0,046; 95% CI: 0,503-0,646) dengan cut-off value sebesar 0,29 pada pasien perempuan usia tua dengan ACS, disamping riwayat infark miokard dan kolesterol HDL sebagai faktor yang signifikan (Dziedzic et al, 2023).…”