Blood Concentrations of Persistent Organic Pollutants and Prediabetes and Diabetes in the General Population of Catalonia

Gasull, Magda; Pumarega, José; Téllez-Plaza, María; Castell, Conxa; Tresserras, Ricard; Lee, Dong Hoon; Porta, Miquel

doi:10.1021/es300712g

Cited by 73 publications

(54 citation statements)

References 37 publications

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“…According to Lee et al (2007), the dioxin-like PCBs showed strong positive associations with diabetes. Also HCB was found to be associated with diabetes in several studies (Wu et al, 2013;Gasull et al, 2012;Codru et al, 2007;Glynn et al, 2000). Whereas we found a strong positive association between PCB118 and "Diabetes", we did not find such an association between marker PCBs and "Diabetes".…”

Section: Diabetescontrasting

confidence: 96%

Internal exposure to organochlorine pollutants and cadmium and self-reported health status: A prospective study

Larebeke¹,

Sioen

Hond

et al. 2015

International Journal of Hygiene and Environmental Health

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Section: Diabetescontrasting

confidence: 96%

Internal exposure to organochlorine pollutants and cadmium and self-reported health status: A prospective study

Larebeke¹,

Sioen

Hond

et al. 2015

International Journal of Hygiene and Environmental Health

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“…Cross-sectional studies performed in other races or ethnicities also showed significant associations between OC pesticides and type 2 diabetes, but their results were not as strongly graded as ours (Codru et al 2007;Cox et al 2007;Philibert et al 2009;Turyk et al 2009). Other previous cross-sectional, longitudinal studies and a meta-analysis, with different adjustment levels, reported that serum levels of OCPs and/or PCBs were positively associated with diabetes risk (Airaksinen et al 2011;Gasull et al 2012;Lee et al 2011;Wu et al 2013). They found a significantly higher concentration of DDTs (especially DDE) in patients with diabetes than without the disease.…”

Section: Discussionmentioning

confidence: 93%

DDT and its metabolites are linked to increased risk of type 2 diabetes among Saudi adults: a cross-sectional study

Al‐Othman

Abd-Alrahman

Al-Daghri

2014

Environ Sci Pollut Res

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Organochlorine (OC) pesticides have recently been associated with type 2 diabetes in several non-Asian general populations. As there is currently an epidemic of type 2 diabetes mellitus in Asia. The prevalence and incidence of diabetes is increasing rapidly worldwide including many Arab Gulf countries. According to a community-based national epidemiological health survey, the overall prevalence of diabetes mellitus in Saudi adults (age group of 30-50 years) is 23.7%. A recent study by Al-Daghri et al. (BMC Med 9:76, 2011) reported that the prevalence of diabetes mellitus in the Kingdom of Saudi Arabia (KSA) is 31.6%. We investigated the associations between OC pesticides and type 2 diabetes in Saudi Arabia using a simple, sensitive, rapid, and selective gas chromatography coupled with mass spectrometry (GC-MS) method that has been recently developed. A total of 280 Saudi adults (136 diabetes mellitus (DM) patients and 144 non-DM controls) were randomly selected from the Riyadh Cohort Study for inclusion. The diagnosis of diabetes was based on established diagnosis and medications taken. Blood dichlorodiphenyltrichloroethane (DDT) and its derivatives were quantified using GC-MS. Residues of DDT and its derivatives were analyzed in serum by means of gas chromatography with a mass spectrometry detector. Associations between DDT exposure and T2DM were analyzed by logistic regression. DDT and its derivatives and serum concentrations of DDT and its derivative DDE showed the strongest and most significant association to type 2 diabetes in both cross-sectional and prospective studies. Associations of DDT and its derivatives varied across different diabetes-related components of the metabolic syndrome. It positively and significantly associated with four of the five of these components especially elevated triacylglycerol, high fasting glucose, high blood pressure, and HOMA-IR but negatively and significantly with HDL. Possible biological mechanisms are discussed. This study confirms previous reports relating organochlorine pesticide (OCP) exposure to diabetes and suggests possible hormonal pathways deserving further exploration. The study will be one of the first to shed light on the associations of serum levels of total DDTs and DDT derivatives among the Saudi Arab ethnicity, and diabetes type 2 chronic noncommunicable diseases are highly prevalent.

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“…High OR in RignellHydbom et al study compared to certain studies except fish consumers (Turyk et al, 2009;Philibert et al, 2009) (Gasull et al, 2012).…”

Section: Comparison Studiesmentioning

confidence: 89%

Association between Dichlorodiphenyldichloroethylene in the Serum and Adipose Tissue with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Fakhri¹,

Sheikhmohammadi²,

Bay³

et al. 2016

GJHS

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The number of diabetics is growing every day. In addition to the main risk factors of type 2 diabetes (obesity, age and etc.) other environmental risk factors such as persistent organic pollutants are also considered. Dichlorodiphenyldichloroethylene is one of the persistent organic pollutants which are produced by the pesticide DDT metabolized and its effects of type 2 diabetes are taken into consideration of many investigators. Inconsistency in the results caused to try to achieve a detailed assessment of the effect of dichlorodiphenyldichloroethylene on type 2 diabetes by systematic review and meta-analysis. In this review study after a systematic review, finally 6 prospective and 7 cross-sectional studies were obtained. After approving the heterogeneity of the studies based on random effect model, it was calculate the mean of odds ratio. Meta-analysis of the pooled random effects of Dichlorodiphenyldichloroethylene was done with type 2 diabetes in prospective and cross-sectional studies. In prospective studies, the highest and lowest odds ratio was 6.1 (95%CI: 1.36-27.27) and 1.01 (95%CI: 0.59-1.70) and cross-sectional studies was 5.5 (95%CI: 1.2-25.10) and 0.61 (95%CI: 0.32-1.15), respectively. In the all studies (sum of prospective and cross-sectional), in the random effect model odds ratio was 1.52 (95%CI: 1.26-1.84) and heterogeneity was 52.1% (ρ heterogeneity =0.009). Increasing concentration of Dichlorodiphenyldichloroethylene in the serum and adipose tissue increased the risk of type 2 diabetes significantly (P<0.001). The results of this review study support the role of dichlorodiphenyldichloroethylene as an environmental risk factor for type 2 diabetes.

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Blood Concentrations of Persistent Organic Pollutants and Prediabetes and Diabetes in the General Population of Catalonia

Cited by 73 publications

References 37 publications

Internal exposure to organochlorine pollutants and cadmium and self-reported health status: A prospective study

Internal exposure to organochlorine pollutants and cadmium and self-reported health status: A prospective study

DDT and its metabolites are linked to increased risk of type 2 diabetes among Saudi adults: a cross-sectional study

Association between Dichlorodiphenyldichloroethylene in the Serum and Adipose Tissue with Type 2 Diabetes: A Systematic Review and Meta-Analysis

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