Blood Compatible Design of a Pulsatile Blood Pump Using Computational Fluid Dynamics and Computer‐Aided Design and Manufacturing Technology

Okamoto, Eiji; Hashimoto, Takeji; Inoue, Taku; Mitamura, Yoshinori

doi:10.1046/j.1525-1594.2003.07183.x

Cited by 25 publications

(15 citation statements)

References 8 publications

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“…15,16 Other studies have also used fluid dynamics analysis techniques to optimize pump design to reduce thrombosis. [17][18][19][20] Such studies confirm the relationship between fluid flow dynamics and thrombosis in blood-contacting devices. This relationship is an important element for consideration in ongoing efforts to develop reduced-size pumps for children and smaller adult patients.…”

supporting

confidence: 62%

Multiscale Analysis of Surface Thrombosis In Vivo in a Left Ventricular Assist System

Yamanaka

Rosenberg²,

Weiss³

et al. 2005

ASAIO Journal

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Thrombosis limits the success of ventricular assist devices as the demand for alternatives to heart transplants is increasing. This study mapped the occurrence of thrombosis in a left ventricular assist system (LVAS) to better understand the biologic response to these devices. Nine calves divided into two groups were implanted with LVAS for 28 to 30 days. One group was anticoagulated, whereas the second group received no long-term anticoagulation. The blood-contacting poly(urethane urea) surfaces of blood sacs in the LVAS were examined for macroscopic thrombi upon retrieval. The sac was partitioned into eight sections and imaged for thrombi by scanning electron microscopy. No difference in thrombosis was observed macroscopically between the groups. Anticoagulation appeared to result in reduction of platelet-like structures, but the presence of fibrin-like structures remained similar between groups. Regional differences correlating with high and low shear stress regions were observed. At the macroscale, fewer thrombi were recorded in the high shear stress ports. At the microscale, features resembling fibrin were observed primarily in the ports and platelet-like features were common in lower shear stress regions. These variations in thrombosis with anticoagulation and location are likely due to varied fluid dynamics within the LVAS blood sac.

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supporting

confidence: 62%

Multiscale Analysis of Surface Thrombosis In Vivo in a Left Ventricular Assist System

Yamanaka

Rosenberg²,

Weiss³

et al. 2005

ASAIO Journal

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“…A moving flexible diaphragm drives the flow and hence is the most important, but also the most difficult part to simulate. Simplification of the problem included: not moving the diaphragm at all, and instead using a velocity boundary condition on the fixed wall 62, 99; assuming the diaphragm is rigid, with a prescribed shape (for example hemisphere) and undergoes prescribed simple motion (for example sinusoidal) 100. The flexible diaphragm motion has also been modelled using a fluid structure interaction with a mixed Lagrangian-Eulerian model 101.…”

Section: Solution Of Flow In a Moving Domainmentioning

confidence: 99%

The use of computational fluid dynamics in the development of ventricular assist devices

Fraser

Taşkın

Griffith

et al. 2011

Medical Engineering & Physics

227

236

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Progress in the field of prosthetic cardiovascular devices has significantly contributed to the rapid advancements in cardiac therapy during the last four decades. The concept of mechanical circulatory assistance was established with the first successful clinical use of heart-lung machines for cardiopulmonary bypass. Since then a variety of devices have been developed to replace or assist diseased components of the cardiovascular system. Ventricular assist devices (VADs) are basically mechanical pumps designed to augment or replace the function of one or more chambers of the failing heart.Computational Fluid Dynamics (CFD) is an attractive tool in the development process of VADs, allowing numerous different designs to be characterized for their functional performance virtually, for a wide range of operating conditions, without the physical device being fabricated. However, VADs operate in a flow regime which is traditionally difficult to simulate; the transitional region at the boundary of laminar and turbulent flow. Hence different methods have been used and the best approach is debatable. In addition to these fundamental fluid dynamic issues, blood consists of biological cells. Device-induced biological complications are a serious consequence of VAD use. The complications include blood damage (haemolysis, blood cell activation), thrombosis and emboli. Patients are required to take anticoagulation medication constantly which may cause bleeding. Despite many efforts blood damage models have still not been implemented satisfactorily into numerical analysis of VADs, which severely undermines the full potential of CFD. This paper reviews the current state of the art CFD for analysis of blood pumps, including a practical critical review of the studies to date, which should help device designers choose the most appropriate methods; a summary of blood damage models and the difficulties in implementing them into CFD; and current gaps in knowledge and areas for future work.

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“…Pulsatile blood pumps have been modelled by e.g., Kim et al (1992) and Okamoto et al (2003). Nonpulsatile rotary blood pumps have been modelled by e.g.…”

Section: Cpeczasopismapanpl; Degruytercom/view/j/cpementioning

confidence: 99%

A New Method for Assessing Haemolysis in a Rotary Blood Pump Using Large Eddy Simulations (LES)

Szwast

Moskal

Piątkiewicz

2017

Chemical and Process Engineering

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The opportunity to assess haemolysis in a designed artificial heart seems to be one of the most important stages in construction. We propose a new method for assessing haemolysis level in a rotary blood pump. This method is based on CFD calculations using large eddy simulations (LES). This paper presents an approach to haemolysis estimation and shows examples of numerical simulation. Our method does not determine the value of haemolysis but allows for comparison of haemolysis levels between different artificial heart constructions.

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Blood Compatible Design of a Pulsatile Blood Pump Using Computational Fluid Dynamics and Computer‐Aided Design and Manufacturing Technology

Cited by 25 publications

References 8 publications

Multiscale Analysis of Surface Thrombosis In Vivo in a Left Ventricular Assist System

Multiscale Analysis of Surface Thrombosis In Vivo in a Left Ventricular Assist System

The use of computational fluid dynamics in the development of ventricular assist devices

A New Method for Assessing Haemolysis in a Rotary Blood Pump Using Large Eddy Simulations (LES)

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