Blood Coagulation Testing Smartphone Platform Using Quartz Crystal Microbalance Dissipation Method

Jia, Yongzhong; Feng, Bin; Zhang, Zhiqi; Li, Chuanyu; Zhang, Wei; Guo, Zhen; Zhao, Han; Zhou, Lianqun

doi:10.3390/s18093073

Cited by 12 publications

(6 citation statements)

References 45 publications

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“…Yet, there was a failure to achieve complete coagulation. In [10], the blood coagulation testing was conducted through a smartphone platform using the quartz crystal microbalance dissipation method. However, the cost was relatively high.…”

Section: Introductionmentioning

confidence: 99%

Polymethyl Methacrylate-Based Smart Microfluidic Point-of-Care Testing of Prothrombin Time and International Normalized Ratio through Optical Detection

Abdulhay

Khnouf

Karain

et al. 2022

Computational and Mathematical Methods in Medicine

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The mechanical heart valve is a crucial solution for many patients. However, it cannot function on the state of blood as human tissue valves. Thus, people with mechanical valves are put under anticoagulant therapy. A good measurement of the state of blood and how long it takes blood to form clots is the prothrombin time (PT); moreover, it is an indicator of how well the anticoagulant therapy is, and of whether the response of the patient to the drug is as needed. For a more specific standardized measurement of coagulation time, an international normalized ratio (INR) is established. Clinical testing of INR and PT is relatively easy. However, it requires the patient to visit the clinic for evaluation purposes. Many techniques are therefore being developed to provide PT and INR self-testing devices. Unfortunately, those solutions are either inaccurate, complex, or expensive. The present work approaches the design of an anticoagulation self-monitoring device that is easy to use, accurate, and relatively inexpensive. Hence, a two-channel polymethyl methacrylate-based microfluidic point-of-care (POC) smart device has been developed. The Arduino based lab-on-a-chip device applies optical properties to a small amount of blood. The achieved accuracy is 96.7%.

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Section: Introductionmentioning

confidence: 99%

Polymethyl Methacrylate-Based Smart Microfluidic Point-of-Care Testing of Prothrombin Time and International Normalized Ratio through Optical Detection

Abdulhay

Khnouf

Karain

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Blood coagulation changes the basic acoustic state of the liquid, and by observing changes in the resonant frequency of the blood, changes in its viscosity can be analyzed and the time course of coagulation time can be obtained. Effective acoustic measurement devices include quartz crystal mass (QCM) balance resonators and surface acoustic waves ( 19 ). A portable coagulation detection method based on a QCM sensor has been proposed that allows researchers to obtain dissipative factor results and coagulation indicators via smartphone analysis.…”

Section: Summary Of the Warfarin Anticoagulant Self-management Modelmentioning

confidence: 99%

Combining portable coagulometers with the Internet: A new model of warfarin anticoagulation in patients following mechanical heart valve replacement

Huang

Huang²,

Han³

2022

Front. Surg.

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Heart valve replacement, as a safe and effective treatment for severe valvular heart disease, can significantly improve hemodynamics in patients. However, such patients then require lifelong anticoagulant therapy. Warfarin, a cheap and highly effective vitamin K antagonist, remains the major anticoagulant recommended for lifelong use following mechanical heart valve replacement. However, the effect of warfarin anticoagulant therapy is complicated by physiological differences among patients and non-compliance with treatment at different degrees. Effective management of warfarin therapy after heart valve replacement is currently an important issue. Portable coagulometers and the emergence of the Internet have provided new opportunities for long-term management of anticoagulation therapy, but the safety and affordability of this approach remain to be fully evaluated. This paper reviews recent progress on the use of portable coagulometers and the Internet in the management of warfarin anticoagulation therapy following mechanical heart valve replacement, which offers opportunities for reducing complications during postoperative anticoagulation and for facilitating patient compliance during follow-up.

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“…For driving the oscillations and reading them out of the quartz crystal, an oscillator circuit and a network analyzer are used in combination. Muller et al (2010) [ 59 ], Hussain et al (2015) [ 60 ], and Yao et al (2018) [ 61 ] have investigated the successful and efficient detection of PT using QCM sensors and have nicely compared them to conventional coagulometers. Yao et al extended the QCM sensing with a novel smartphone/Bluetooth-based testing platform for fast coagulation measurements as shown in Figure 9 a,b.…”

Section: Point Of Care Pt/inrmentioning

confidence: 99%

“… ( a ) Photograph of the smartphone/Bluetooth-based coagulation testing platform using quartz crystal microbalance dissipation method [ 61 ]. ( b ) Typical frequency and dissipation curves during PT measurements.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Evolving Paradigm of Prothrombin Time Diagnostics with Its Growing Clinical Relevance towards Cardio-Compromised and COVID-19 Affected Population

Saha

Bajpai

Krishna

et al. 2021

Sensors

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Prothrombin time (PT) is a significant coagulation (hemostasis) biomarker used to diagnose several thromboembolic and hemorrhagic complications based on its direct correlation with the physiological blood clotting time. Among the entire set of PT dependents, candidates with cardiovascular ailments are the major set of the population requiring lifelong anticoagulation therapy and supervised PT administration. Additionally, the increasing incidence of COVID affected by complications in coagulation dynamics has been strikingly evident. Prolonged PT along with sepsis-induced coagulopathy (SIC score > 3) has been found to be very common in critical COVID or CAC-affected cases. Considering the growing significance of an efficient point-of-care PT assaying platform to counter the increasing fatalities associated with cardio-compromised and coagulation aberrations propping up from CAC cases, the following review discusses the evolution of lab-based PT to point of care (PoC) PT assays. Recent advances in the field of PoC PT devices utilizing optics, acoustics, and mechanical and electrochemical methods in microsensors to detect blood coagulation are further elaborated. Thus, the following review holistically aims to motivate the future PT assay designers/researchers by detailing the relevance of PT and associated protocols for cardio compromised and COVID affected along with the intricacies of previously engineered PoC PT diagnostics.

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Blood Coagulation Testing Smartphone Platform Using Quartz Crystal Microbalance Dissipation Method

Cited by 12 publications

References 45 publications

Polymethyl Methacrylate-Based Smart Microfluidic Point-of-Care Testing of Prothrombin Time and International Normalized Ratio through Optical Detection

Polymethyl Methacrylate-Based Smart Microfluidic Point-of-Care Testing of Prothrombin Time and International Normalized Ratio through Optical Detection

Combining portable coagulometers with the Internet: A new model of warfarin anticoagulation in patients following mechanical heart valve replacement

Evolving Paradigm of Prothrombin Time Diagnostics with Its Growing Clinical Relevance towards Cardio-Compromised and COVID-19 Affected Population

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