Blood Coagulation System and Carbon-Based Nanoengineering for Biomedical Application

Panigrahi, Abhishek; Yadav, Pooja; Beura, Samir Kumar; Singh, Sarita

doi:10.1007/978-981-16-3645-5_12

Cited by 1 publication

(1 citation statement)

References 44 publications

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“…Interestingly, carbon-based materials (CNMs) share a direct effect on the complement and coagulation cascade (Figure 2B). CNMs are indeed used in coagulation disorder therapy because of their potential to interact with platelets and induce thrombosis and hemolysis [44].…”

Section: Characterization Of the Dddtmoamentioning

confidence: 99%

Characterization of ENM Dynamic Dose-Dependent MOA in Lung with Respect to Immune Cells Infiltration

et al. 2022

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The molecular effects of exposures to engineered nanomaterials (ENMs) are still largely unknown. In classical inhalation toxicology, cell composition of bronchoalveolar lavage (BAL) is a toxicity indicator at the lung tissue level that can aid in interpreting pulmonary histological changes. Toxicogenomic approaches help characterize the mechanism of action (MOA) of ENMs by investigating the differentially expressed genes (DEG). However, dissecting which molecular mechanisms and events are directly induced by the exposure is not straightforward. It is now generally accepted that direct effects follow a monotonic dose-dependent pattern. Here, we applied an integrated modeling approach to study the MOA of four ENMs by retrieving the DEGs that also show a dynamic dose-dependent profile (dddtMOA). We further combined the information of the dddtMOA with the dose dependency of four immune cell populations derived from BAL counts. The dddtMOA analysis highlighted the specific adaptation pattern to each ENM. Furthermore, it revealed the distinct effect of the ENM physicochemical properties on the induced immune response. Finally, we report three genes dose-dependent in all the exposures and correlated with immune deregulation in the lung. The characterization of dddtMOA for ENM exposures, both for apical endpoints and molecular responses, can further promote toxicogenomic approaches in a regulatory context.

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Section: Characterization Of the Dddtmoamentioning

confidence: 99%