Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis

Cerinic, Marco Matucci; Valentini, Gabriele; Sorano, G.G.; D’Angelo, Salvatore; Cuomo, Giovanna; Fenu, Luigi; Generini, Sergio; Cinotti, S.; Morfini, Massimo; Pignone, Alberto Moggi; Guiducci, Serena; Rosso, Angela Del; Kalfin, Reni; Das, Dipak K.; Marongiu, Francesco

doi:10.1053/sarh.2002.50011

Cited by 128 publications

(79 citation statements)

References 47 publications

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“…Dysfunction of endothelium and micro-and macrovascular damage also leads to accelerated atherosclerotic process in systemic sclerosis with involvement of anti-endothelial antibodies and adhesive molecules like ICAM-1 (intercellular adhesion molecule 1) (ref. 25 ). The presence of anti-SSA/Ro antibodies and dyslipoproteinemia with low levels and dysfunction of HDL is related to AT in Sjögren's syndrome 26 .…”

Section: Discussionmentioning

confidence: 99%

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Smrzova¹,

Horák²,

Skácelová³

et al. 2014

BIOMED PAP

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Aim. Accelerated atherosclerosis in systemic lupus erythematosus (SLE) is an important cause of morbidity and mortality. The pathophysiology of accelerated atherosclerosis in SLE is mediated by factors such as inflammatory processes in the vascular wall, specific antibodies, dyslipoproteinemia, endothelial dysfunction and the high prevalence of traditional risk factors for cardiovascular diseases. In this context, we evaluated the clinical significance of ultrasound examination of the carotic arteries in the early diagnosis of atherosclerosis. Methods. The study included 63 patients with SLE (female: male 53:10, mean age 38.4±12.7 years, mean disease duration 143.0 ±82.6 months), 24 patients had lupus nephritis. The control group consisted of 24 volunteers (female: male 20:4 mean age 31.04±8.59). Intima media thickness (IMT) was measured by ultrasound on both sides. The results were correlated with markers of lipid spectrum, anti-dsDNA, antinucleosomal and anticardiolipin antibodies, lupus anticoagulant and complement components. Clinical disease activity and damage were evaluated by SLEDAI and SLICC indices. Lifestyle and other important factors were examined per protocol and by questionnaire. Results. A significant difference of IMT (P≤0.03) was found between the lupus patients and sex-age adjusted healthy controls with an in mean IMT in SLE patients of 0.569±0.11 mm, in control group 0.495±0.05 mm. A significant correlation between IMT and disease duration, age, positivity of lupus anticoagulant, use of ACE inhibitors, glomerular filtration and serum creatinine were found. No difference in IMT was found between patients with or without lupus nephritis. Conclusion. IMT measurement could be used as a clinical predictor of risk of accelerated atherosclerosis in lupus patients.

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Section: Discussionmentioning

confidence: 99%

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Smrzova¹,

Horák²,

Skácelová³

et al. 2014

BIOMED PAP

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“…Pathogenesis of the disease is complex: the pivotal steps are endothelial cell damage, immune activation and collagen production by fibroblasts [1]. Endothelial involvement is associated with the increase of some circulating markers including von Willebrand factor (vWF), vascular endothelial growth factor (VEGF), intracellular adhesion molecule-1 (ICAM-1), monocyte chemotactic protein-1 (MCP-1) [2,3].…”

Section: Introductionmentioning

confidence: 99%

Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

et al. 2010

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Results: After ESWT we observed a rapid and persistent reduction of RSS and decrease of VAS. There was no difference in skin thickness before and after ESWT; however we observed a more regular skin structure and an improvement in skin vascularization 90 days after treatment. EPCs and CECs increased 60 and 90 days after treatment, while serological biomarkers showed no variation before and after therapy. Conclusions: ESWT resulted in an improvement of VAS, RSS and of skin vascularscore. An increase of CECs and EPCs was also observed after therapy.

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“…Since the pioneering studies by Kahaleh and LeRoy, focusing attention on the important role of endothelial cells in SSc pathogenesis and originally demonstrating that specific endothelial cell proteins such as the von Willebrand factor (vWf) are abnormally elevated in the sera of patients with SSc [36], there has been intense investigation and numerous studies have described potentially important biomarkers that may provide information about the functional status of endothelial cells and their dysfunction in SSc [39][40][41][42][43]. In the original study of Kahaleh, vWf was found elevated in the plasma of patients with SSc and patients with Raynaud's phenomenon in comparison with normal controls [36].…”

Section: Biomarkers Of Endothelial Cell Dysfunctionmentioning

confidence: 99%

Biomarkers in Systemic Sclerosis

Lafyatis

Jimenez

2016

Scleroderma

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Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis

Cited by 128 publications

References 47 publications

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient

Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

Biomarkers in Systemic Sclerosis

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