Blood coagulation factors and platelet response to drug‐induced hepatitis and hepatosis in rats

Abstract

The liver plays an important role in maintaining blood hemostasis. It participates in carbohydrate, protein, and lipid metabolism, and eliminates various endogenous and exogenous molecules. A multitude of substances, including vitamins (A, D, B12, K, E, and B1), are stored in its cells. The liver is also the site of synthesis of plasma proteins, most coagulation factors, anticoagulant proteins, compounds of fibrinolysis, and stimulators of erythropoesis. 1 Liver pathologies lead to complex disorders in the blood hemostasis system in which the procoagulant and anticoagulant potentials are imbalanced, causing thrombotic events or hemorrhages. 2,3

Biomarkers of Hepatic Toxicity: An Overview

“…All liver illnesses affect the PT. 131 Cirrhosis bleeders have 90% to 100% elevated PT, while nonbleeders have 50% to 55%. 132 Seventy-five percent of viral hepatitis patients had increased PT.…”

Phospholipid composition of bile and blood in rats under correction of experimental fatty hepatosis

“…Modern scientific studies using various models of fatty degeneration of liver and statistical analysis of patients' condition indicators in this hepatopathology indicate positive effects in the case of phospholipid-containing drugs and the introduction of phospholipid-containing supplements into the diet of patients with pathology of the hepatobiliary system (Dajani & Popovic, 2020). Essential phospholipids have a hepatoprotective effect, which has been demonstrated in studies on hepatocytes in vitro by D. Wupperfeld et al (2022), and in animal models by D. Korolova et al (2023). Phospholipid-containing drugs are actively used in the treatment of patients with fatty liver disease (Yin et al, 2021).…”

“…Due to the growing prevalence of fatty degeneration of liver, it is becoming a serious scientific and clinical problem (Pydyn et al, 2020;Huh et al, 2022). In veterinary practice, animal liver damage, in particular fatty degeneration of liver is noted as often occurring (up to 25%) and has a different aetiology, requires the development of appropriate non-invasive diagnostic methods and effective complex treatment ( Imbery et al, 2022;Korolova et al, 2023). Development of fatty hepatosis according to experts (Ota, 2021) is associated with impaired glucose and lipid metabolism in the liver, with hydrophobic bile acid toxicity, macrophage dysfunction and liver stellate cell activation, progressive fibrogenesis, and due to genetic, epigenetic, and environmental factors that contribute to the progression of fibrosis and the risk of hepatocellular carcinoma.…”

Experimental study of the hepatoprotective effect of the 2.6-dimethyl-n-pyridine-oxide complex with succinic acid (Poteitin) on the model of toxic hepatitis caused by tetrachloromethane

“…Серед забруднювачів довкілля важливе місце посідають пестициди, які при надходженні до організму разом з іншими ксенобіотиками, що знаходяться в навколишньому середовищі, можуть спричиняти різні патологічні стани організму людини та призводити до тяжких віддалених наслідків [1][2][3][4]. Більшість пестицидів є гепатотропними речовинами, тому за їхнього впливу на організм ступінь порушення гепатобіліарної системи та гомеостазу організму в цілому залежать від функціональних можливостей печінки як основного органу біотрансформації та детоксикації ксенобіотиків [2,[5][6][7][8].…”

“…Pesticides occupy an important place among environmental pollutants, which, when entering the body together with other xenobiotics in the environment, can cause various pathological conditions in the human body and lead to serious longterm consequences [1][2][3][4]. Most pesticides are hepatotropic substances, therefore, under their influence on body, the degree of disruption of the hepatobiliary system and the homeostasis of the body as a whole depend on the functional capabilities of the liver as the main organ of biotransformation and detoxification of xenobiotics [2,[5][6][7][8].…”