Blood Coagulation During Infancy.

Owen, Charles A.; Hoffman, Gary R.; Ziffren, Sidney E.; Smith, Helmut Walser

doi:10.3181/00379727-41-10612

Cited by 54 publications

(9 citation statements)

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“…Mean pro¬ thrombin time of infants fed cow's milk showed a sharp decrease, while the prothrombin time of all other groups not given vitamin paren¬ terally continued to rise. Twenty-four hours after the first feeding (Fig 3, statistical comparisons, Table) there was no significant difference be¬ tween infants given vitamin par¬ enterally at birth (mean, 14 Twenty-four hours after the first feeding no significant difference ex¬ isted between the 22 second pro¬ thrombin time of breast fed infants and the 20 second time of infants fed bottled human milk (Table 1), al¬ though in the first 12 hours, the pro¬ thrombin time of breast fed infants was significantly lower than that of infants bottle fed human milk.…”

Section: Resultsmentioning

confidence: 92%

“…Although the mean prothrombin times for the infants who did not receive vitamin parenterally was longer at birth and at the time of the first feeding than that of infants who did receive vitamin parenterally, the differences are not significant. Twenty-four hours after the first feeding the mean prothrombin time of 14 -Sequential mean microprothrombin times of 67 infants who did not receive vitamin parenterally, compared with mean prothrombin times of 13 patients who did receive vitamin par¬ enterally.…”

Section: Resultsmentioning

confidence: 99%

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Role of Feeding and Vitamin K in Hypoprothrombinemia of the Newborn

Keenan¹,

Jewett²,

Glueck³

1971

Arch Pediatr Adolesc Med

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Whole blood prothrombin times were determined serially in five groups of randomly selected well newborn "term" infants, none of whom had clinical evidence of bleeding. Prothrombin values in infants given menadione sodium bisulfite (vitamin K) parenterally shortly after birth were stable. The remainder of the infants who were not given vitamin K were divided into subgroups. Twenty-four hours after the first feeding, prothrombin activity of infants fed cow's milk did not differ significantly from that of infants given vitamin K at birth. In contrast, prothrombin times 24 hours after the first feeding of breast fed infants, of infants given bottled human milk, or of infants receiving only sterile water, were all significantly longer than that of infants given vitamin K parenterally. The responses of these newly born infants to the various feeding regimens appear to represent an in vivo assay for dietary vitamin K. The data document hypoprothrombinemia in the majority of infants who do not receive vitamin K parenterally and emphasize the importance of the administration of a small prophylactic dose of the vitamin to all newly born infants.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Role of Feeding and Vitamin K in Hypoprothrombinemia of the Newborn

Keenan¹,

Jewett²,

Glueck³

1971

Arch Pediatr Adolesc Med

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“…The same is true for the plasma of newborn human beings. 15 Another possibility is that protein M is the main effective component in prothrombin complex preparations found to have therapeutic value for hemophiliac patients with inhibitors. 16-ls…”

Section: Time In Minutesmentioning

confidence: 99%

Three Aspects of Prothrombin Activation Related to Protein M, Ecarin, Acutin, Meizothrombin 1 and Prethrombin 2*

Seegers

Chen

Ghosh

et al. 1981

Annals of the New York Academy of Sciences

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“…The study was repeated with both one-and two-stage tests and was reported on in 1939. 12 Again it was stated that the two-stage plasma prothrombin value was about one-third that in adults and did not reach adult levels for several months. By the one-stage test, however, the newborn's prothrombin was near adult levels.…”

mentioning

confidence: 99%

The Revolution in Concepts of Coagulation*

Owen

1981

Annals of the New York Academy of Sciences

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Blood Coagulation During Infancy.

Cited by 54 publications

References 0 publications

Role of Feeding and Vitamin K in Hypoprothrombinemia of the Newborn

Role of Feeding and Vitamin K in Hypoprothrombinemia of the Newborn

Three Aspects of Prothrombin Activation Related to Protein M, Ecarin, Acutin, Meizothrombin 1 and Prethrombin 2*

The Revolution in Concepts of Coagulation*

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