Blood Coagulation and the Biochemist

Macfarlane, Robert

doi:10.1177/036985646400300306

Cited by 2 publications

(1 citation statement)

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“…20 It was concluded that the venom-lecithin mixture was equivalent to thromboplastin, which thus could be a mixture of a water-soluble venom-like enzyme and a phospholipid cofactor. 21 An easy laboratory test for clotting was developed by Armand Quick at this point, the one-stage prothrombin time (PT), in which excess thromboplastin provided by brain extract could be used to measure the clotting time, and which is only dependent on the concentration of prothrombin. 22 Prolonged PT in patients with normal prothrombin concentration led to the discovery of first factor V, and then factor VII, and not too late thereafter, factor X.…”

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confidence: 99%

Russell Viper Venom: A Journey from the Bedside to the Bench and Back to the Bedside

Thachil

2023

Semin Thromb Hemost

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Russel Viper Venom (RVV) is widely used as a diagnostic test for antiphospholipid syndrome (APS). But the history of how this venom came to be discovered is well known. Dr Patrick Russel is responsible for the identification of the venom during his work on snake bites in India while Dr Robert Macfarlane used it to staunch bleeding in persons with haemophilia. The ability to directly activate factor X led RVV to the laboratory diagnosis of APS. More recently, it has come back to clinical world with a potential for an engineered factor X activator from RVV to be used in the treatment of haemophilia.

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confidence: 99%