Blood Coagulation and Fibrinolysis in Relation to Coronary Heart Disease

Merskey, Clarence; Gordon, Hymie; Lackner, Henriette; Schrire, V.; Kaplan, Berkan; Sougin-Mibashan, R.; Nossel, Hymie L.; Moodie, A. D.

doi:10.1136/bmj.1.5168.219

Cited by 109 publications

(23 citation statements)

References 19 publications

(22 reference statements)

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“…Higher activity was initially reported in Trends in CAD in sub-Saharan Africans O Akinboboye et al African compared to European men. 51,56 The comparative study on a group of Nigerian and European men confirmed these findings. 57,58 Similar trends have been reported in Gambia and Uganda.…”

Section: Trends In Cad Insupporting

confidence: 57%

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Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Akinboboye

Idris²,

Akinkugbe

2003

J Hum Hypertens

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It has been suggested that the prevalence of coronary artery disease (CAD) is steadily increasing in subSaharan Africa. To address this issue, we conducted a Medline search of English language articles on cardiovascular diseasesFand specifically CAD in AfricaF from 1966 to 1997. The prevalence of CAD and related complications is relatively low in most regions in Africa compared to that obtained in the economically developed countries, although the situation is rapidly changing due to trends in urbanization, changes in lifestyle, acquisition of technology and the increasing numbers of tertiary care institutions. There are variations in reported prevalence rates within the different regions, but there is an upward trend in all the regions of the sub-Saharan Africa. This trend is believed to be related to the increasing frequencies of CAD risk factors in the subcontinent.

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Section: Trends In Cad Insupporting

confidence: 57%

“…A South African study also reported no difference. 51 Factor VIIc: There is also a positive correlation between factor VIIc and both plasma cholesterol and triglyceride concentrations. The Northwick Park Heart Study first demonstrated this association.…”

Section: Trends In Cad Inmentioning

confidence: 99%

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Akinboboye

Idris²,

Akinkugbe

2003

J Hum Hypertens

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“…In Forwell & Ingram's (1957) (Bergsagel & Hougie, 1956), and this is an additional reason for thinking that an increase in AHG activity accounts more satisfactorily for the hypercoagulability produced by adrenaline; for the earlier stages of clotting are more time-consuming than the later (Biggs, 1955) (Merskey, Gordon & Lackner, 1960) and Australian aborigines (Pitney & Elliott, 1960), the mean AHG level was very close to the mean increase here reported in Europeans after adrenaline infusions. Pitney & Elliott (1960) also foulnd a similar mean level in 22 white Australians with hyperglobulinaemia.…”

Section: Discussionsupporting

confidence: 48%

Increase in antihaemophilic globulin activity following infusion of adrenaline

Ingram¹

1961

The Journal of Physiology

152

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Christie, Graham-Stewart & Ingram (1960) described an abdomino-perineal excision of the rectum in a haemophilic of moderate severity who received animal antihaemophilic globulin (AHG) to cover the operation and post-operative period. Responses to this material were measured by assaying the AHG activity in the patient's plasma before and after each dose; and on two occasions the responses were strikingly high. These peaks corresponded to episodes of acute haemorrhage requiring immediate blood transfusion; and there was also an intermediate peak coinciding with a lesser haemorrhage insufficient to necessitate transfusion. It was not clear whether the high responses correlated with the severity of the bleeding or with blood transfusion; but in another haemophilic an unexpectedly high AHG level was associated with haematemesis while the patient was under observation only. It seemed therefore that haemorrhage was the correlated factor; and in considering a possible mechanism, the extensive previous work on the acceleration of blood coagulation after the administration of adrenaline was recalled: this was reviewed by Forwell (1955), and the problem was reexamined by Forwell & Ingram (1957), who thought at that time that the effect depended on an increase in the activity of Factor V. A possible explanation of the observations in the haemophilics was that haemorrhage had led to a release of adrenaline (Greever & Watts, 1959), and that this had in turn brought about an increase in the activity of AHG in the patients' plasmas. Forwell & Ingram (1957) had not examined AHG in their experimental subjects who had received adrenaline; it therefore seemed of interest to extend the earlier work to include AHG. The results of these experiments are now presented. METHODS The healthy experimental volunteers taking part in the present investigation were senior male medical students. The haemophilic subjects were adult patients, also of course, males, and in good health apart from their haemophilia. Neither they nor the healthy subjects were fasted before testing.

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“…The higher levels of fibrinolytic activity in the blood o f African Negroes as compared to Asians and Britons confirm the findings of previous studies [13][14][15][16][17].…”

Section: Discussionsupporting

confidence: 81%

Blood Fibrinolytic Activity in Young Britons, Africans and Asians in Relation to their <sup>‘</sup>Weight-for-Height’ Standard

Is¹

1970

J Vasc Res

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The blood fibrinolytic activity was studied in 93 volunteers belonging to 3 different racial groups and related to their body weight adjusted to the ‘weight-for-height’ standard. No difference was found in this activity when overweight, underweight and standard weight British and Asian males were compared. Increased blood fibrinolytic activity was observed in overweight African Negroes as compared to those of standard weight, and decreased blood fibrinolytic activity was discovered in underweight British women when compared to those of standard weight or overweight. It is suggested that the increased fibrinolytic activity in overweight African males may be due to their increased muscular bulk, since muscles are a potent contributor of plasminogen activator to the circulation.

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Blood Coagulation and Fibrinolysis in Relation to Coronary Heart Disease

Cited by 109 publications

References 19 publications

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Increase in antihaemophilic globulin activity following infusion of adrenaline

Blood Fibrinolytic Activity in Young Britons, Africans and Asians in Relation to their <sup>‘</sup>Weight-for-Height’ Standard

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