Blood cells as biological trait markers in affective disorders

Muscettola, Giovanni; Lauro, Andrea Di; Giannini, Clemente Patrizio

doi:10.1016/0022-3956(84)90032-3

Cited by 10 publications

(2 citation statements)

References 67 publications

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“…Two additional studies report reduced platelet [3Hlimipramine binding in depressives, similar to the studies measuring uptake directly (Innis et al, 1987;Roy et al, 1987). However, other reports have found that L3H]imipramine binding is not modified in depression (Mellerup et al, 1982;Muscettola et al, 1984;Katona et al, 1986;Egrise et al, 19861, nor is it even correlated with the severity of depression (Carstens et al, 1986;Braddock et al, 1986;Georgatos et al, 1987). Given the recognition that i3HIimipramine binding displaced by other tricyclic antidepressants is heterogeneous (Humphreys et al, 1988;Graham et al, 19891, it would seem appropriate to repeat many of these studies using more selective ligands that do not label multiple sites when used properly, such as [3H]paroxetine (Backstrom et al, 1989).…”

Section: L3h]imipramine Binding To Plateletsmentioning

confidence: 93%

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

Caldecott-Hazard

Morgan

DeLeon-Jones

et al. 1991

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117

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The present document is the second of three parts in a review that focuses on recent data from clinical and animal research concerning the biochemical bases of depressive disorders, diagnosis, and treatment. Various receptor/transmitter theories of depressive disorders are discussed in this section. Specifically, data supporting noradrenergic, serotonergic, cholinergic, dopaminergic, GABAergic, and peptidergic theories, as well as interactions between noradrenergic and serotonergic, or cholinergic and catecholaminergic systems are presented. Problems with the data and future directions for research are also discussed. A previous publication, Part I of this review, dealt with the classification of depressive disorders and research techniques for studying the biochemical mechanisms of these disorders. A future publication, Part III of this review, discusses treatments for depression and some of the controversies in this field.

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Section: L3h]imipramine Binding To Plateletsmentioning

confidence: 93%

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

Caldecott-Hazard

Morgan

DeLeon-Jones

et al. 1991

Synapse

117

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“…Moreover, low platelet MAG activity has been associated with schizophrenia, panicularly in male chrome schizophrenics (Gattaz et al, 1981;Rose et al, 1986;Wyatt et al, 1980), although again this finding is contro-versiaI, at least with regard to its validity as an indicator ofvulnerability (Proppingand Friedl, 1979). Low platelet MAG activity has also been associated with afTective disorders, especially the bipolar type (Belmakeretal., 1980;Gershonetal., 1980;Mann, 1979;Muscettola et al, 1984), again with conflicting results. A few studies have investigated plasma BChE, finding reduced activity in male, medication-free, chronic schizophrenics (Domino and Krause, 1972) and no abnormalities in afTective disorders (Mathew et al, 1982;Milslocet al, 1975).…”

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confidence: 99%

Reflection of Central Aminergic-Cholinergic Imbalance by Peripheral Enzymes in Psychiatric Disorders?*

Fritze

Beckmann²

1988

Pharmacopsychiatry

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Disturbances of central catecholaminergic-cholinergic balances have been discussed as causing affective disorders and schizophrenia. Such imbalances might be due to abnormalities of the metabolizing enzymes, especially their activities relative to each other. With this in mind, the activities of platelet monoamine oxidase and plasma butyrylcholinesterase (pseudocholinesterase) were determined spectrophotometrically in 33 psychiatric patients and eight controls. No significant differences could be detected for the enzyme activities as such and their relationship as expressed by their ratios. Thus, these peripheral enzymes seem to be unlikely indicators of supposed central imbalances.

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Platelet research in psychiatry

Wirz‐Justice

1988

Experientia

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The platelet is one of the most researched biological markers in psychiatry. Characteristics of MAO activity, 5-HT uptake, imipramine and alpha 2-adrenergic receptor binding, for example, are similar in platelet and CNS. Methodological factors are not negligible, and range from diagnostic specificity and drug effects to the normal physiological variability of age and hormone-related changes, circadian and seasonal rhythms. As yet, there are no clear state or trait platelet markers in affective disorders and schizophrenia that can be unequivocally used to detect vulnerability to the illness, predict therapeutic response, define clinical diagnostic entities or follow the course of the illness. However, platelet markers are increasingly being used in careful studies to monitor psychopharmacological effects (an in vivo assay of all active metabolites), different ligands can be specific markers for certain aspects of a psychiatric illness (e.g. alpha 2-adrenergic receptors and weight loss), and this homogeneous preparation of human cells is an increasingly important tool in studying mechanisms in pathophysiology. More longitudinal studies are required to establish functional relationships between platelet variables and psychopathology.

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Blood cells as biological trait markers in affective disorders

Cited by 10 publications

References 67 publications

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

Reflection of Central Aminergic-Cholinergic Imbalance by Peripheral Enzymes in Psychiatric Disorders?*

Platelet research in psychiatry

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