2015
DOI: 10.1007/s11302-015-9462-7
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Blood cells: an historical account of the roles of purinergic signalling

Abstract: The involvement of purinergic signalling in the physiology of erythrocytes, platelets and leukocytes was recognised early. The release of ATP and the expression of purinoceptors and ectonucleotidases on erythrocytes in health and disease are reviewed. The release of ATP and ADP from platelets and the expression and roles of P1, P2Y 1 , P2Y 12 and P2X1 receptors on platelets are described. P2Y 1 and P2X1 receptors mediate changes in platelet shape, while P2Y 12 receptors mediate platelet aggregation. The change… Show more

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Cited by 64 publications
(64 citation statements)
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References 373 publications
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“…31,106 P2Y 1 and P2X7 receptors are the dominant nucleotide receptor subtypes expressed by mature erythrocytes, whereas A 2A receptors are expressed by embryonic red blood cells. ATP is released from human erythrocytes in response to mechanical deformation or hypoxia.…”
Section: Blood Cellsmentioning
confidence: 99%
See 2 more Smart Citations
“…31,106 P2Y 1 and P2X7 receptors are the dominant nucleotide receptor subtypes expressed by mature erythrocytes, whereas A 2A receptors are expressed by embryonic red blood cells. ATP is released from human erythrocytes in response to mechanical deformation or hypoxia.…”
Section: Blood Cellsmentioning
confidence: 99%
“…ATP, released as a cotransmitter with noradrenaline from sympathetic nerves, acts on P2X1 receptors to constrict vascular smooth muscle. 31 Increased release of ATP as a sympathetic cotransmitter relative to noradrenaline release in spontaneously hypertensive rats (SHR) has been reported. 155,156 Guanethidine was used in early times for the treatment of hypertension, probably by inhibiting the release of both ATP and noradrenaline from sympathetic nerves.…”
Section: Vascular Diseasesmentioning
confidence: 99%
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“…P2Y receptors modulate several signaling events including adenylyl cyclase, phospholipase C, and ion channel activation [16,18]. P2 receptors are present on all blood cells [19]. It is reported that some pore-forming toxins require purinergic signaling to elicit their toxicity [16].…”
Section: Introductionmentioning
confidence: 99%
“…Neurotransmission, secretion, transduction, cell proliferation, motility, and differentiation are typical examples of biological functions modulated by nucleotides or nucleosides acting as extracellular signaling molecules [5][6][7][8][9][10][11]. Burnstock's early hypothesis that ATP, the major intracellular molecule providing the energy required for multiple biochemical and biophysical processes, may actually function as an extracellular non-adrenergic and noncholinergic signaling molecule [12,13] was received with great skepticism [14,15].…”
Section: Introductionmentioning
confidence: 99%