Blood cell redox status and fatty acids

Lagarde, Michel; Véricel, Evelyne; Chabannes, B.; Prigent, Annie‐France

doi:10.1016/0952-3278(95)90015-2

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…These findings were supported by the clinical observations that aspirin treatment (5), and alcohol consumption (6) did not abolish release of ␤ thromboglobulin from the platelet ␣ granules. Other reports revealed that downregulatory effect of neutrophils on platelet activity were enhanced to the similar extend by aspirin (7), and by alcohol (8). Moreover, our data are in agreement with other clinical observations that chronic aspirin therapy (9), and alcohol consumption (10) decreases platelet aggregation.…”

Section: Dear Sirsupporting

confidence: 93%

Take an Aspirin or Have a Drink: Antecedent Aspirin and Moderate Alcohol Consumption Similarly Affect Baseline Platelet Characteristics in Patients with Acute Myocardial Infarction

Serebruany¹,

Lowry²,

Study³

2000

Thromb Haemost

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Section: Dear Sirsupporting

confidence: 93%

Take an Aspirin or Have a Drink: Antecedent Aspirin and Moderate Alcohol Consumption Similarly Affect Baseline Platelet Characteristics in Patients with Acute Myocardial Infarction

Serebruany¹,

Lowry²,

Study³

2000

Thromb Haemost

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“…There is ample evidence for a crucial role of glutathione peroxidase in platelets in the arachidonic acid metabolism, which until now has been ascribed solely to GPx-1 [3,12]. To our knowledge, no evidence for the occurrence of PHGPx at the same time and its possible role in platelets has yet been presented.…”

Section: Introductionmentioning

confidence: 99%

Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism

SUTHERLAND¹,

SHANKARANARAYANAN²,

SCHEWE³

et al. 2000

Biochem. J.

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The 12-lipoxygenase pathway of arachidonic acid metabolism in platelets and other cells is bifurcated into a reduction route yielding 12-hydroxyeicosatetraenoic acid (12-HETE) and an isomerization route forming hepoxilins. Here we show for the first time the presence of phospholipid hydroperoxide glutathione peroxidase (PHGPx) protein and its activity in platelets. The ratio of the activity of PHGPx to that of cytosolic glutathione peroxidase (GPx-1) was consistently found to be approx. 1 : 60 in platelets and UT7 megakaryoblasts. Moreover, short-lived PHGPx mRNA was detected in megakaryocytes but not in platelets. Carboxymethylation of selenium-containing glutathione peroxidases by iodoacetate, which results in the inactivation of PHGPx and GPx-1 without inhibition of 12lipoxygenase, markedly altered the pattern of arachidonic acid metabolism in human platelets. Whereas the formation of 12-HETE was inhibited by 80 %, a concomitant accumulation of 12-hydroperoxyeicosatetraenoic acid (12-HpETE) by two orders of magnitude as well as the formation of hepoxilins A $

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Biological Relevance of the 12-Lipoxygenase Pathway for Platelet and Lymphocyte Functions

Lagarde

Calzada

Zakaroff

et al. 1999

Advances in Experimental Medicine and Biology

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Blood cell redox status and fatty acids

Cited by 8 publications

References 20 publications

Take an Aspirin or Have a Drink: Antecedent Aspirin and Moderate Alcohol Consumption Similarly Affect Baseline Platelet Characteristics in Patients with Acute Myocardial Infarction

Take an Aspirin or Have a Drink: Antecedent Aspirin and Moderate Alcohol Consumption Similarly Affect Baseline Platelet Characteristics in Patients with Acute Myocardial Infarction

Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism

Biological Relevance of the 12-Lipoxygenase Pathway for Platelet and Lymphocyte Functions

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