Blood Cell Count Indexes of Systemic Inflammation in Carotid Artery Disease: Current Evidence and Future Perspectives

Dettori, Paola; Paliogiannis, Panagiotis; Pascale, Rosa M.; Zinellu, Angelo; Mangoni, Arduino A.; Pintus, Gianfranco

doi:10.2174/1381612826666201222155630

Cited by 11 publications

(9 citation statements)

References 79 publications

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“…The NLR, a cell inflammatory index that is easily derived from routine haematological parameters, is increasingly being studied as a diagnostic and prognostic biomarker in a wide range of disease states [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. In the context of COPD, several observational studies have reported that, in the stable phase of the disease, the NLR is significantly higher in patients with specific comorbidities, e.g., lung cancer and metabolic syndrome, and those at risk of AECOPD [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Systematic Review and Meta-Analysis of the Association between the Neutrophil-to-Lymphocyte Ratio and Adverse Outcomes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Zinellu

Pau

et al. 2022

JCM

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The neutrophil-to-lymphocyte ratio (NLR) predicts adverse outcomes in stable chronic obstructive pulmonary disease (COPD); however, its prognostic role in acute exacerbations (AECOPD) is less clear. We conducted a systematic review and meta-analysis of the association between the NLR on admission and adverse outcomes (mortality, need for mechanical ventilation, transfer to the intensive care unit, length of stay, pulmonary hypertension, or their combination) in AECOPD by searching PubMed, Web of Science, and Scopus from inception to April 2022. Risk of bias and certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Recommendation, Assessment, Development, and Evaluation, respectively. In 15 studies (n = 10,038 patients), the NLR was significantly associated with the risk of adverse outcomes (odds ratio = 1.054, 95% CI 1.016 to 1.093, p = 0.005; low certainty of evidence; standard mean difference = 0.82, 95% CI 0.57 to 1.06, p < 0.001; high certainty of evidence). Pooled sensitivity, specificity, and area under the curve were 0.71 (95% CI 0.64 to 0.77), 0.73 (95% CI 0.65 to 0.80), and 0.78 (95% CI 0.74 to 0.81), respectively. In our study, the NLR on admission was significantly associated with adverse outcomes in AECOPD patients, suggesting the potential utility of this biomarker for early risk stratification and management in this group.

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Section: Discussionmentioning

confidence: 99%

A Comprehensive Systematic Review and Meta-Analysis of the Association between the Neutrophil-to-Lymphocyte Ratio and Adverse Outcomes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Zinellu

Pau

et al. 2022

JCM

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“…The distribution of the volume of circulating red blood cells, normally between 80–100 fL, can significantly increase (anisocytosis) in several physiological and pathophysiological states and is expressed as a relative increase in RDW values [ 16 , 52 , 53 , 54 ]. Generally, the presence of anisocytosis is favoured by a reduced production and release of mature red blood cells from the bone marrow and/or a reduced destruction of old blood cells in the liver and/or spleen [ 16 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet and Red Blood Cell Volume Indices in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Zinellu

Mangoni

2022

Diagnostics

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Alterations in the volume of platelets (mean platelet volume, MPV; platelet distribution width, PDW) and erythrocytes (red blood cell distribution width, RDW) have been reported in rheumatoid arthritis (RA) and might serve as diagnostic biomarkers. We conducted a systematic review and meta-analysis of the MPV, PDW, and RDW in RA patients and healthy controls. Relevant articles were searched in PubMed, Web of Science, Scopus, and Google Scholar from inception to June 2022. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist and certainty of evidence was assessed using GRADE. In 23 studies (2194 RA patients and 1565 healthy controls), the RDW, but not MPV or PDW, was significantly higher in RA patients (standardized mean difference, SMD = 0.96, 95% CI 0.78 to 1.15, p < 0.001; moderate certainty of evidence). The substantial heterogeneity observed (I2 = 75.1%, p < 0.001) was virtually removed in a subgroup of prospective studies. In sensitivity analysis, the magnitude of the effect size was not substantially modified by sequentially removing individual studies. There was no significant publication bias. No significant associations were observed between the effect size and pre-defined study or patient characteristics. The results of our study suggest that the RDW might be a useful biomarker for the diagnosis of RA, and complement the clinical information provided by other patient characteristics and laboratory parameters (PROSPERO registration number: CRD42022349432).

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“…The elderly and those with the comorbidities of HTN (44.5% vs. 34.6%, p < 0.001), CAD (13.3% vs. 6.6%, p < 0.001), and ESRD (9.7% vs. 2.2%, p < 0.001) had a higher risk of mortality outcome. A significantly lower GCS score (median (IQR): 5 [3][4][5][6][7][8][9][10][11][12] vs. 15 [11][12][13][14][15], p < 0.001) and higher ISS (median (IQR): 25 [25][26][27][28][29] vs. 17 [16][17][18][19][20][21][22][23][24], p < 0.001) were observed in the death group than in the survivors group. Under stratification by ISS, significantly fewer dead patients had an ISS of 1-15 and 16-24, and more dead patients had an ISS ≥ 25 than the survivors.…”

Section: Patient Demographicsmentioning

confidence: 99%

“…The initial WBC count could be a predictor of subsequent bloodstream infection in burn patients [1]. Furthermore, the derived ratio of platelets and WBC subtypes are readily available parameters that might predict outcome [2][3][4][5][6]. For example, the monocyte-to-lymphocyte ratio (MLR) in osteoporosis patients [7], the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in oncology patients [8][9][10], and the NLR in fracture patients [11] were also reported to be novel predictors of mortality in these specific patient populations.…”

Section: Introductionmentioning

confidence: 99%

Association of Platelets and White Blood Cells Subtypes with Trauma Patients’ Mortality Outcome in the Intensive Care Unit

Rau

Hsieh

et al. 2021

Healthcare

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Background: White blood cell (WBC) subtypes have been suggested to reflect patients’ immune-inflammatory status. Furthermore, the derived ratio of platelets and WBC subtypes, including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), is proposed to be associated with patient outcome. Therefore, this study aimed to identify the association of platelets and white blood cells subtypes with the mortality outcome of trauma patients in the intensive care unit (ICU). Method: The medical information from 2854 adult trauma patients admitted to the ICU between 1 January 2009 and 31 December 2019 were retrospectively retrieved from the Trauma Registry System and classified into two groups: the survivors group (n = 2524) and the death group (n = 330). The levels of monocytes, neutrophils, lymphocytes, platelets, and blood-drawn laboratory data detected upon patient arrival to the emergency room and the derived MLR, NLR, and PLR were calculated. Multivariate logistic regression analysis was used to determine the independent effects of univariate predictive variables on mortality occurrence. Result: The results revealed the patients who died had significantly lower platelet counts (175,842 ± 61,713 vs. 206,890 ± 69,006/μL, p < 0.001) but higher levels of lymphocytes (2458 ± 1940 vs. 1971 ± 1453/μL, p < 0.001) than the surviving patients. However, monocyte and neutrophil levels were not significantly different between the death and survivor groups. Moreover, dead patients had a significantly lower PLR than survivors (124.3 ± 110.3 vs. 150.6 ± 106.5, p < 0.001). However, there was no significant difference in MLR or NLR between the dead patients and the survivors. Multivariate logistic regression revealed that male gender, old age, pre-existing hypertension, coronary artery disease and end-stage renal disease, lower Glasgow Coma Scale (GCS), higher Injury Severity Score (ISS), higher level of lymphocytes and lower level of red blood cells and platelets, longer activated partial thromboplastin time (aPTT), and lower level of PLR were independent risk factors associated with higher odds of trauma patient mortality outcome in the ICU. Conclusion: This study revealed that a higher lymphocyte count, lower platelet count, and a lower PLR were associated with higher risk of death in ICU trauma patients.

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Blood Cell Count Indexes of Systemic Inflammation in Carotid Artery Disease: Current Evidence and Future Perspectives

Cited by 11 publications

References 79 publications

A Comprehensive Systematic Review and Meta-Analysis of the Association between the Neutrophil-to-Lymphocyte Ratio and Adverse Outcomes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

A Comprehensive Systematic Review and Meta-Analysis of the Association between the Neutrophil-to-Lymphocyte Ratio and Adverse Outcomes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Platelet and Red Blood Cell Volume Indices in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Association of Platelets and White Blood Cells Subtypes with Trauma Patients’ Mortality Outcome in the Intensive Care Unit

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