Blood cannabinoid molar metabolite ratios are superior to blood THC as an indicator of recent cannabis smoking

Kosnett, Michael J.; Ma, Ming; Dooley, Gregory P.; Wang, George Sam; Friedman, Kyle; Brown, Timothy L; Henthorn, Thomas K.; Brooks‐Russell, Ashley

doi:10.1080/15563650.2023.2214697

Cited by 3 publications

(1 citation statement)

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“…Therefore, they could potentially be used in conjunction with THC detection to show that cannabis has been used very recently. An example from another matrix is that molar metabolite ratios of cannabinoids in blood were better indicators of recent cannabis smoking than whole blood THC alone [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Cannabinoids detected in exhaled breath condensate after cannabis use

Berry,

Brooks-Russell,

Beuning

et al. 2024

J. Breath Res.

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Cannabinoids can be detected in breath after cannabis use, but different breath matrices need to be explored as studies to date with filter-based devices that collect breath aerosols have not demonstrated that breath-based measurements can reliably identify recent cannabis use. Exhaled breath condensate (EBC) is an unexplored aqueous breath matrix that contains condensed volatile compounds and water vapor in addition to aerosols. EBC was collected from participants both before and at two time points (0.7 h ± 0.2 h and 1.7 h ± 0.3 h) after observed cannabis use. Eleven different cannabinoids were monitored with liquid chromatography tandem mass spectrometry (LC-MS/MS). Five different cannabinoids, including Δ9-tetrahydrocannabinol (THC), were detected in EBC collected from cannabis users. THC was detected in some EBC samples before cannabis use, despite the requested abstinence period. THC was detected in all EBC samples collected at 0.7 h post use and decreased for all participants at 1.7 h. Non-THC cannabinoids were only detected after cannabis use. THC concentrations in EBC samples collected at 0.7 h showed no trend with sample metrics like mass or number of breaths. EBC sampling devices deserve further investigation with respect to modes of cannabis use (e.g., edibles), post use time points, and optimization of cannabinoid recovery.

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Section: Discussionmentioning

confidence: 99%