Blood biochemistry parameters in patients with hemophilia

Abstract

Aim. To describe the blood biochemistry parameters in patients with hemophilia considering the level of lacking coagulation factor and AВ0 blood group to clarify the risk factors for complications of hemophilia and concomitant diseases. Methods. 300 patients with hemophilia A admitted due to bleedings were examined. The serum levels of albumin, urea, bilirubin, cholesterin, iron, aspartate aminotransferase were examined using an automatic biochemical analyzer. The control group included 185 healthy males of similar age. Results. Severe degree of hemophilia was diagnosed in 42% of patients, medium severity - in 36%, mild - in 22%. Low metabolic activity was found in patients with hemophilia. Blood cholesterol level of 3 mmol/l and less was the risk factor of anemia development in patients with hemophilia of any severity. In hemophilic patients with 0(I) blood group, serum iron level decrease was registered regardless of hemophilia severity, in patients with other blood groups decrease was noted in patients with medium and severe hemophilia. Serum iron level of 12 μmol/l and less was the risk factor for anemia. The albumin level was the highest in patients with AB (IV) blood group, with only a few cases of anemia diagnosed in these patients. Conclusion. In patients with hemophilia there is a tendency of losing cholesterol and serum iron while bleeding, which is the risk factor for anemia and other concomitant conditions development. Treating patients with hemophilia, it is important to consider the specific personal metabolic features associated with the AВ0 blood group and the level of lacking coagulation.