2021
DOI: 10.1016/j.hrthm.2020.09.017
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Blood-based 8-hydroxy-2′-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

Abstract: BACKGROUND Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2 0 -deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence and postoperative atrial fibrillation (POAF) after treatment.OBJECTIVE The purpose of this study was to investigate whether serum levels of 8-OHdG correlate with the stage of AF, recurrence after… Show more

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Cited by 24 publications
(19 citation statements)
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“…Thus, SOD and GSH‐Px can reflect the body's ability to resist oxidative damage. Moreover, 8‐OHdG, a product of free radical‐induced oxidative damage, has been widely used as a marker for DNA damage and cardiovascular diseases 67,68 . Our results show that the levels of MDA and 8‐OHdG in hypertension patients increased, whereas SOD and GSH‐Px markedly decreased, indicating that oxidative stress occurred during the pathogenesis of hypertension in studied pedigrees.…”
Section: Discussionmentioning
confidence: 60%
“…Thus, SOD and GSH‐Px can reflect the body's ability to resist oxidative damage. Moreover, 8‐OHdG, a product of free radical‐induced oxidative damage, has been widely used as a marker for DNA damage and cardiovascular diseases 67,68 . Our results show that the levels of MDA and 8‐OHdG in hypertension patients increased, whereas SOD and GSH‐Px markedly decreased, indicating that oxidative stress occurred during the pathogenesis of hypertension in studied pedigrees.…”
Section: Discussionmentioning
confidence: 60%
“…Additionally, some of them, such as 8-OHdG, do not show specificity for HD. Its level is also significantly increased in the course of other diseases, including cardiovascular pathology [154,155]. This is a common problem when determining potential biomarkers closely related to a specific disease entity, which complicates the interpretation of results and affects their credibility.…”
Section: Discussionmentioning
confidence: 99%
“…In AF patients, an increase in oxidative DNA damage markers (i.e., 8-oxoG and 53BP1) [26] and differentially expressed proteins, closely related to oxidative stress-related signaling pathways [116], have been observed. Moreover, serum levels of 8-hydroxy-2 -deoxyguanosine (8-OHdG), a vital oxidative DNA damage by-product formed by exonucleases during DNA repair processes, positively correlate with AF progression, onset of postoperative AF (poAF), and recurrence after AF treatment [118], substantiating a role for oxidative stress-induced DNA damage in AF development. In the next part of this review, two major underlying biochemical events associated with oxidative DNA damage and repair in AF and a summary of novel therapeutic treatment implications for AF will be discussed.…”
Section: Oxidative Dna Damage and Repair In Afmentioning
confidence: 99%