Blood B-Type Natriuretic Peptide and Dialysis: Present Assessment and Future Analyses

Flemmer, Mark; Rajab, Hussein; Mathena, Tracy; Paulson, James F.; Perkins, Susan; Whelan, Thomas V.; Chiu, Ritche; McCullough, Peter A.

doi:10.1097/smj.0b013e318189aa56

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…One out of five men were current smokers (21.0%), while very few women smoked (0.3%). The median number of servings of fruits and vegetables eaten per day was very low (1.86 servings/day, data not shown) compared to the five or more servings recommended by the Ministry of Health, Oman (20).…”

Section: Resultsmentioning

confidence: 84%

Associations of Physical Activity and Sitting Time With the Metabolic Syndrome Among Omani Adults

Mabry

Winkler

Reeves

et al. 2012

Obesity

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Most findings on associations of physical activity and sedentary behavior with the metabolic syndrome are from developed countries; thus, we examined these relationships in adults from Sur, Oman. The Sur Healthy Lifestyle Survey (n = 1,335) used the World Health Organization (WHO) Stepwise methodology to assess chronic disease risk factors. Odds ratios for the metabolic syndrome were estimated using logistic regression models for domains of physical activity (work, transport, and leisure) and sitting time, and adjusted for confounding variables. Compared to their counterparts doing the least physical activity, lower odds of the metabolic syndrome were observed among those with higher work activity (0.60; 95% confidence interval (CI): 0.45, 0.80) and transport activity (0.69; 95% CI: 0.47, 1.00), but not leisure activity (0.91; 95% CI: 0.64, 1.32). Odds of the metabolic syndrome were higher in those who sat for ≥6 h daily compared to <3 h daily (odds ratio = 1.60, 95% CI: 1.04, 2.44), but not after further adjustment for physical activity. This is the first evidence from the Arabian Gulf on associations of physical activity and sitting time with the metabolic syndrome and provides empirical evidence to inform national physical activity guidelines, policies and programs.

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Section: Resultsmentioning

confidence: 84%

Associations of Physical Activity and Sitting Time With the Metabolic Syndrome Among Omani Adults

Mabry

Winkler

Reeves

et al. 2012

Obesity

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“…Understanding the mechanisms that underlie elevation in BNP/NT-proBNP levels among ESRD patients is of particular importance to help frame appropriate therapeutic decisions. Previous studies have suggested that the mechanism for a rise in NPs among ESRD patients was a result of LV structural and functional abnormalities [6] , [41] , enabling NPs to be a potential marker of LV hypertrophy in ESRD [42] , [43] . In addition,there is emerging evidence that increases in circulating NPs may indicate myocardial ischemia or necrosis, due to the coronary atherosclerosis prevalent in patients with ESRD [6] , [44] , supported by a strong relationship between elevated BNP/NT-proBNP and cardiovascular mortality/events in our analysis.…”

Section: Discussionmentioning

confidence: 99%

B-Type Natriuretic Peptide and Prognosis of End-Stage Renal Disease: A Meta-Analysis

et al. 2013

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BackgroundThe prognostic importance of B-type natriuretic peptide (BNP) or N-terminal pro BNP (NT-proBNP) in patients with end-stage renal disease (ESRD) remains controversial.Methodology/Principal FindingsWe conducted an unrestricted search from the MEDLINE and EMBASE in all languages that were published between 1966 and Augest2013. Twenty-seven long-term prospective studies met our inclusion criterias. From the pooled analysis, elevated BNP/NT-proBNP was significantly associated with increased all cause mortality [odds ratio (OR), 3.85; 95% CI, 3.11 to 4.75], cardiovascular mortality (OR, 4.05; 95% CI, 2.53 to 6.84), and cardiovascular events (OR, 7.02; 95% CI, 2.21 to 22.33). The funnel plot showed no evidence of publication bias. The corresponding pooled positive and negative likelihood ratio for prediction of all cause mortality were 1.86 (95% CI, 1.66 to 2.08) and 0.48 (95% CI, 0.42 to 0.55), respectively.Conclusions/SignificanceBNP/NT-proBNP is a promising prognostic tool to risk-stratify the patients with ESRD. Further investigations are warranted to elucidate the specific pathogenic mechanisms and the impact of other potential prognostic factors.

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“…BNP/NT-proBNP concentrations have not been shown to correlate with short-term changes in volume state [55],[56]. Their role as volume markers in the medium to long-term remains an important, unresolved issue.…”

Section: B-type Natriuretic Peptidesmentioning

confidence: 99%

Cardiac biomarkers in dialysis

2017

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Cardiovascular disease is the major cause of death, accounting for approximately 40 percent of all-cause mortality in patients receiving either hemodialysis or peritoneal dialysis. Cardiovascular risk stratification is an important aspect of managing dialysis patients as it enables early identification of high-risk patients, so therapeutic interventions can be optimized to lower cardiovascular morbidity and mortality. Biomarkers can detect early stages of cardiac injury so timely intervention can be provided. The B-type natriuretic peptides (Brain Natriuretic peptide [BNP] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]) and troponins have been shown to predict mortality in dialysis patients. Suppression of tumorigenicity 2 (ST2) and galectin-3 are new emerging biomarkers in the field of heart failure in both the general and dialysis populations. This article aims to discuss the current evidence regarding cardiac biomarker use to diagnose myocardial injury and monitor the risk of major adverse cardiovascular events in patients undergoing dialysis.

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Blood B-Type Natriuretic Peptide and Dialysis: Present Assessment and Future Analyses

Cited by 11 publications

References 23 publications

Associations of Physical Activity and Sitting Time With the Metabolic Syndrome Among Omani Adults

Associations of Physical Activity and Sitting Time With the Metabolic Syndrome Among Omani Adults

B-Type Natriuretic Peptide and Prognosis of End-Stage Renal Disease: A Meta-Analysis

Cardiac biomarkers in dialysis

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