Blood antioxidant defense system and dietary survey of elderly diabetic men

Chen, Linda H.; Osio, Y.; Anderson, James W.

doi:10.1016/s0167-4943(98)00127-7

Cited by 6 publications

(5 citation statements)

References 57 publications

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“…This barrier includes either exogenous (e.g. ascorbate, tocopherols, carotenoids, biflavonoids) or endogenous (proteins, bilirubin, uric acid, cholesterol, GSH) compounds [20] . Obvi- ously, any injury of the plasma barrier to oxidation can result in oxidative tissue damage and, ultimately, it can lead to OS-related diseases and early aging.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study

et al. 2009

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Background: Oxidative stress (OS) plays a crucial role in pathological conditions during the early neonatal period. The newborns are susceptible to oxidative damage due to high metabolic rate and low levels of antioxidant enzymes. Lutein has been found to have protective functions in adult humans as antioxidant. Aim: To evaluate the effects of lutein on OS in newborns. We tested the hypothesis that lutein would act both by increasing antioxidant capacity and inhibiting OS. Methods: This was a randomized, double-blind, placebo-controlled, single-center study. 20 healthy term newborns were assigned to receive lutein or placebo (lutein and control group, respectively) at 12 and 36 h after birth. Total hydroperoxides (TH), as marker of OS, and biological antioxidant potential (BAP), as marker of antioxidant power, were detected on cord blood and at 48 h of life in all babies. Results: TH significantly increased from birth to 48 h in the control group (p = 0.02), but not in the lutein group. In the lutein group, BAP significantly increased after 48 h (p = 0.02), showing a strengthening of antioxidant activity due to lutein. At 48 h of life, compared with those in the control group, neonates assigned to receive lutein had significantly lower TH levels (p = 0.04) and higher BAP levels (p = 0.028). Conclusions: Lutein administration in newborns increases the levels of BAP decreasing TH. The enhancement of antioxidant activity in plasma clearly results in protecting newborn from perinatal OS. These preliminary results, adding a new contribution in antioxidant strategies, strongly require to be confirmed by RCT.

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Section: Discussionmentioning

confidence: 99%

Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study

et al. 2009

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“…α-tocopherol participates in protecting polyunsaturated fatty acids in membranes and lipoproteins against peroxidation by scavenging lipid peroxyl radicals and thus breaking chain propagation steps. (11) Individuals with low blood levels of vitamin E were found to be more likely to develop type 2 diabetes. (12) Some previous studies have reported lower plasma α-tocopherol concentrations in patients with type 2 diabetes than in healthy control subjects.…”

Section: Selected Metabolic Parameters In Diabeticsmentioning

confidence: 99%

“…Active α-tocopherol can be regenerated by ascorbic acid or by ubiquinol. (5) Polarized light (PL) application belongs to the light therapy methods. Over the last years, biological eff ects of a single color from the visible spectrum were described.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effect of antioxidants and polarized light on selected metabolic and echocardiographic parameters in diabetics

Palacka¹,

Murı́n²,

Kucharská³

et al. 2009

Cor Vasa

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Background: Enhanced production of reactive oxygen species and decreased antioxidant function play a role in the development of chronic diabetic complications. Objective: To determine whether supplementation with antioxidants (coenzyme Q 10 (CoQ 10), α-lipoic acid (ALA), α-tocopherol) and simultaneous polarized light (PL) application can improve selected metabolic and echocardiographic parameters of the left ventricle (LV) in diabetics. Patients and methods: Twenty patients with type 2 diabetes were enrolled in a prospective study. Antioxidants were taken in two daily doses (60 mg hydrosoluble CoQ 10 , 100 mg ALA and 200 mg α-tocopherol) and PL was simultaneously applied on neuropathic diabetic ulcers (twice daily for 10 minutes in pulse regimen) for three months. Paired Student´s t-test was used for statistical analysis at the baseline and after the three-month treatment. Results: Supplementation with CoQ 10 , ALA and α-tocopherol with simultaneous PL application reduced plasma fi brinogen and lactate dehydrogenase activity, while plasma levels of CoQ 10 and α-tocopherol were stimulated. An improvement was found in echocardiographic parameters. Conclusions: Hydrosoluble CoQ 10 , ALA and α-tocopherol supplementation with simultaneous polarized light application increased the plasma concentrations of antioxidants, decreased lactate dehydrogenase activity, and improved selected LV echocardiographic parameters.

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“…The antioxidants defence system of the body which protects the cell from oxidative damage caused by ROS is speculated to be suppressed with age, resulting in functional disorders or tissue injury related to the ageing process (Satoh et al, 2004). Therefore oxidative stress may be the consequence of an increase in prooxidants and/or a decrease in antioxidant defenses (Chena et al, 1999). The prevention of oxidative damage through enhancement of the anti-oxidative defence status and decrease of ROS level can be an important factor that counteracts ageing and age-associated disorders.…”

Section: Introductionmentioning

confidence: 99%