1987
DOI: 10.1016/s0140-6736(87)91075-0
|View full text |Cite
|
Sign up to set email alerts
|

Blood and Protein Loss via Small-Intestinal Inflammation Induced by Non-Steroidal Anti-Inflammatory Drugs

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
92
0
1

Year Published

1989
1989
2015
2015

Publication Types

Select...
7
1
1

Relationship

2
7

Authors

Journals

citations
Cited by 201 publications
(95 citation statements)
references
References 16 publications
2
92
0
1
Order By: Relevance
“…It is also known that unsaturated phospholipids reduced gastrotoxicity (Leyck et al, 1985), and the DP-155 structure is ideal in this respect. Indomethacin is also known for inducing a high prevalence of lesions in the small and large bowels (Whittle, 1998;Rainsford et al, 2003), including ulceration and inflammation that can cause hypoproteinemia, anemia, and perforation of the gut (Bjarnason et al, 1987;Hawkey, 1998). In the current study, there were indeed signs of intestinal toxicity, namely enteritis accompanied by blood and protein loss to the intestine.…”
Section: Dp-155 Safer Indomethacin Reducing A␤ 1-42 1253mentioning
confidence: 99%
“…It is also known that unsaturated phospholipids reduced gastrotoxicity (Leyck et al, 1985), and the DP-155 structure is ideal in this respect. Indomethacin is also known for inducing a high prevalence of lesions in the small and large bowels (Whittle, 1998;Rainsford et al, 2003), including ulceration and inflammation that can cause hypoproteinemia, anemia, and perforation of the gut (Bjarnason et al, 1987;Hawkey, 1998). In the current study, there were indeed signs of intestinal toxicity, namely enteritis accompanied by blood and protein loss to the intestine.…”
Section: Dp-155 Safer Indomethacin Reducing A␤ 1-42 1253mentioning
confidence: 99%
“…Закономерное следствие такого воспаления -развитие анемии, гипо-и диспротеине-мии, что, естественно, усугубляет тяжесть основного заболе-вания, по поводу которого были назначены НПВП [19][20][21]. Известно, что у части пациентов с ревматическими заболе-ваниями имеется гипоальбуминемия, связанная с энтераль-ными белковыми потерями, но не зависящая от приема НПВП.…”
Section: рис 2 возможный патогенез нпвп-индуцированной энтеропатииunclassified
“…The first human studies to suggest lower GI injury with NSAID employed indirect measures of damage including permeability changes and scanning of labelled neutrophils 12 . Capsule endoscopy supported these findings by associating mucosal erosions with NSAID 13,14 and showing a lower incidence with COX-2 inhibitors, while epidemiological studies and the results of some (but not most) outcome studies 15 pointed to a high rate of complicated lower GI events on NSAID that fell with COX-2 inhibitors.…”
Section: Applying the Lessons From Upper Gi To Lower Gi Studiesmentioning
confidence: 99%
“…Is intestinal injury by NSAID a matter of COX inhibition or do other mechanisms predominate? These questions have been posed by Bjarnason and colleagues 12 but much remains to be discovered. 2.…”
Section: Future Questionsmentioning
confidence: 99%