Blood and liver lipids in torpid and aroused little brown bats, Myotis lucifugus

Esher, Robert J.; Fleischman, Alan I.; Lenz, Paul H.

doi:10.1016/0300-9629(73)90329-0

Cited by 17 publications

(6 citation statements)

References 12 publications

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“…The increase in total phospholipids during the hibernating state (Table I) is in agreement with studies of other hibernating mammals (55)(56)(57). Individual phospholipid classes of a hibernating mammal have been analyzed in only one previous study by Wells, et al (55).…”

Section: Discussionsupporting

confidence: 88%

Changes in phospholipid composition in hibernating ground squirrel,Citellis lateralis, and their relationships to membrane function at reduced temperatures

Aloia

Pengelley

Bolen

et al. 1974

Lipids

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Section: Discussionsupporting

confidence: 88%

Changes in phospholipid composition in hibernating ground squirrel,Citellis lateralis, and their relationships to membrane function at reduced temperatures

Aloia

Pengelley

Bolen

et al. 1974

Lipids

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“…7. Each year, seasonal hibernators undergo major shifts in nutrient intake and fuel utilization that result in a switch to a primarily lipid-based metabolism during the winter months; As noted in other species [8], [9], [16], [17], [27], hibernation increased plasma cholesterol levels in 13-lined ground squirrels. Plasma cholesterol concentration was similar in SPR and SUM squirrels, but rose gradually over the first two months of hibernation concomitant with a decrease in body mass.…”

Section: Discussionmentioning

confidence: 75%

Cholesterol and Lipoprotein Dynamics in a Hibernating Mammal

et al. 2011

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Hibernating mammals cease feeding during the winter and rely primarily on stored lipids to fuel alternating periods of torpor and arousal. How hibernators manage large fluxes of lipids and sterols over the annual hibernation cycle is poorly understood. The aim of this study was to investigate lipid and cholesterol transport and storage in ground squirrels studied in spring, summer, and several hibernation states. Cholesterol levels in total plasma, HDL and LDL particles were elevated in hibernators compared with spring or summer squirrels. Hibernation increased plasma apolipoprotein A-I expression and HDL particle size. Expression of cholesterol 7 alpha-hydroxylase was 13-fold lower in hibernators than in active season squirrels. Plasma triglycerides were reduced by fasting in spring but not summer squirrels. In hibernators plasma β-hydroxybutyrate was elevated during torpor whereas triglycerides were low relative to normothermic states. We conclude that the switch to a lipid-based metabolism during winter, coupled with reduced capacity to excrete cholesterol creates a closed system in which efficient use of lipoproteins is essential for survival.

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“…10C), and northern elephant seal pups following respective fasts of 4, 6, 10, 30, and 49 days (41,420,465,491,552). In contrast, fasting increases plasma cholesterol in the raptor B. buteo (by 25% and reversed with feeding), the rabbit (by 330% after 1 month), and in mammalian hibernators that do not eat during winter (17,154,158,182,315,323,421,478,519,541,575). For hibernators, at least, the increase in plasma cholesterol during fasting appears to stem from the reduction in fecal output and bile production, as both are routes for cholesterol removal (421).…”

Section: Cholesterolmentioning

confidence: 86%

Integrative Physiology of Fasting

Secor

Carey

2016

Comprehensive Physiology

136

144

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Extended bouts of fasting are ingrained in the ecology of many organisms, characterizing aspects of reproduction, development, hibernation, estivation, migration, and infrequent feeding habits. The challenge of long fasting episodes is the need to maintain physiological homeostasis while relying solely on endogenous resources. To meet that challenge, animals utilize an integrated repertoire of behavioral, physiological, and biochemical responses that reduce metabolic rates, maintain tissue structure and function, and thus enhance survival. We have synthesized in this review the integrative physiological, morphological, and biochemical responses, and their stages, that characterize natural fasting bouts. Underlying the capacity to survive extended fasts are behaviors and mechanisms that reduce metabolic expenditure and shift the dependency to lipid utilization. Hormonal regulation and immune capacity are altered by fasting; hormones that trigger digestion, elevate metabolism, and support immune performance become depressed, whereas hormones that enhance the utilization of endogenous substrates are elevated. The negative energy budget that accompanies fasting leads to the loss of body mass as fat stores are depleted and tissues undergo atrophy (i.e., loss of mass). Absolute rates of body mass loss scale allometrically among vertebrates. Tissues and organs vary in the degree of atrophy and downregulation of function, depending on the degree to which they are used during the fast. Fasting affects the population dynamics and activities of the gut microbiota, an interplay that impacts the host's fasting biology. Fasting-induced gene expression programs underlie the broad spectrum of integrated physiological mechanisms responsible for an animal's ability to survive long episodes of natural fasting.

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Blood and liver lipids in torpid and aroused little brown bats, Myotis lucifugus

Cited by 17 publications

References 12 publications

Changes in phospholipid composition in hibernating ground squirrel,Citellis lateralis, and their relationships to membrane function at reduced temperatures

Changes in phospholipid composition in hibernating ground squirrel,Citellis lateralis, and their relationships to membrane function at reduced temperatures

Cholesterol and Lipoprotein Dynamics in a Hibernating Mammal

Integrative Physiology of Fasting

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