Blood and Guts: Diarrhea from Colonic Involvement in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Zikos, Thomas; Triadafilopoulos, George; Berubé, Caroline; Regalia, Kirsten

doi:10.1007/s10620-018-5264-4

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Histopathology of both patients revealed lymphocytic infiltrates. The patient who presented with the colonic mass died within days of diagnosis [ 7 ]. Our patient received chemotherapy and is currently in remission.…”

Section: Discussionmentioning

confidence: 99%

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Presenting as Chronic Diarrhea; An Unusual Presentation of a Common Lymphoproliferative Disorder

Gowda

Abdullah

Sharma

et al. 2021

Case Reports in Gastrointestinal Medicine

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Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the United States. It has a variable presentation with most patients having asymptomatic lymphocytosis. Many other patients present with lymphadenopathy or enlargement of other organs of the reticuloendothelial system. However, CLL can present with extramedullary involvement. Most commonly, this is in the form of skin or central nervous system involvement, though rarely it can present with gastrointestinal involvement. Here, we present the case of a 70-year-old Caucasian male who presented with chronic diarrhea for over 4 months. After failing conservative treatment, a colonoscopy was performed which showed diffuse mucosal nodularities with a biopsy revealing CLL. The patient was treated successfully with chemotherapy and his diarrhea improved. This is a differential to keep in mind in patients with chronic diarrhea, once the more common causes have been ruled out.

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Section: Discussionmentioning

confidence: 99%

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Presenting as Chronic Diarrhea; An Unusual Presentation of a Common Lymphoproliferative Disorder

Gowda

Abdullah

Sharma

et al. 2021

Case Reports in Gastrointestinal Medicine

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show abstract

“…When gastrointestinal (GI) infiltration occurs, it shows non specific clinical and endoscopic aspects. It may also remain asymptomatic or with an unremarkable mucosal surface at endoscopy [2][3]. When the histological biopsy examination shows a prominent mucosal lymphoid infiltrate, a differential diagnosis with inflammation and with other GI lymphomas should be made, based on a careful clinical history and an accurate morphological evaluation with immunohistochemistry.…”

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confidence: 99%