Blood and Cerebrospinal Fluid Biomarkers in Vascular Dementia and Alzheimer’s Disease

Gorelick, Philip B.

doi:10.1016/j.cger.2022.08.001

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…The most commonly measured biomarkers to assess cognitive impairment are betaamyloid protein, tau protein, light neurofilaments, and quantitative or topographic biomarkers of neurodegeneration or neuronal damage (CSF t-tau, FDG-PET, or structural MRI) [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…Elahi et al [41], as part of the SPRINT-MIND study, analyzed the correlation between hypertensive treatments and vascular dementia without further investigating the correlation with HF. Gorelick [34], in his review, analyzes biomarkers of vascular dementia. Hoyer-Kimura et al [37] analyzed light neurofilaments in mice that were induced by permanent ligation and myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

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A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

Pagano,

Corallo,

D’Aleo

et al. 2024

Biomolecules

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Background: Heart failure is an epidemiologically relevant disease because of the aging population and widespread lifestyles that promote it. In addition to the acute event, it is possible for the disease to become chronic with periodic flare-ups. It is essential to study pathology from a diagnostic and prognostic point of view and to identify parameters for effective monitoring. In addition, heart failure is associated with multiple comorbidities, including cognitive impairment, which is monitored clinically but not through specific biomarkers in these patients. The purpose of this review is to gather the most recent scientific evidence on a few possible biomarkers previously identified for monitoring heart failure and associated cognitive impairment. Methods: We surveyed studies inherent to a set of previously identified markers, evaluating English-language articles from the past five years conducted in adult heart failure patient populations. We used the databases PubMed, Web of Sciences, and Cochrane Library for search studies, and we considered articles published in journals with an impact factor greater than five in the publication year. Results: Among the biomarkers evaluated, a concordant indication for serial measurements for heart failure monitoring emerged only for interleukin-6. For the other markers, there is still little evidence available, which is interesting but sometimes conflicting. Interesting studies have also emerged for biomarkers of cognitive decline assessed in patients with heart failure, confirming the hypotheses of the increasingly studied heart-brain correlation. Conclusion: Certainly, further studies in large populations are needed to identify effective biomarkers for monitoring heart failure and associated cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

Pagano,

Corallo,

D’Aleo

et al. 2024

Biomolecules

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“…Implementing biosensors holds significant potential for enhancing the efficiency and safety of predator eradication strategies. Over recent decades, the utilization of biosensors for volatile biomarker detection has played a critical role in various fields, contributing to advancements in pharmaceuticalrelated tests [128][129][130][131][132], diagnoses and prognosis of rare diseases [133][134][135][136][137], risk estimation [138][139][140][141][142], food safety [143][144][145][146], environmental assessment [147][148][149][150][151][152][153], and pollution monitoring [154][155][156][157][158][159][160].…”

Section: Techniques Of Detection Of Voc Biomarkersmentioning

confidence: 99%

Review of Predator Emitted Volatile Organic Compounds and Their Potential for Predator Detection in New Zealand Forests

Lu,

Whitton,

Strand

et al. 2024

Forests

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This review covers the volatile organic compounds (VOCs) emitted by the bodies and secretions of introduced mammalian predators in New Zealand forests, with a specific focus on mice, rats, ferrets, stoats, and possums. The primary aim is to compile information on these VOCs and assess the potential of exploiting these VOCs as unique biomarkers for predator detection in the forest. While a universal VOC has yet to be identified, the review discusses various VOCs associated with predators and their potential as unique biomarkers for detecting the presence of predators, including 2-heptanone, 4-heptanone, 2-octanone, and benzaldehyde. Furthermore, a brief overview of different VOC detection techniques is provided, connecting the selection of biosensing techniques with the detection of volatile biomarkers. Further research and advancement in the biosensing field hold substantial potential to enhance biomarker detection technologies and elevate predator management strategies within New Zealand forests.

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“…In ~50% of these cases, the condition appears to be vascular in nature, and it is not clear whether exposure to NPC would be directed to the vascular cells possibly affected by menopause (discussed in [ 99 ]), or the other cells. Interestingly, vascular cells can also produce tau tangles [ 99 ], one of the targets for therapy in AD [ 114 , 115 ]. Liu-Ambrose and colleagues [ 116 , 117 , 118 , 119 ] have discussed the ability of exercise in perhaps pre-menopausal females and beyond to prevent or inhibit the vascular-related changes that may lead to dementia or loss of cognition, implying that the cognitive changes in the brain cells may be indirect and associated with loss of vascular integrity in a subset of post-menopausal females.…”

Section: The Way Forwardmentioning

confidence: 99%

Use of Brain-Derived Stem/Progenitor Cells and Derived Extracellular Vesicles to Repair Damaged Neural Tissues: Lessons Learned from Connective Tissue Repair Regarding Variables Limiting Progress and Approaches to Overcome Limitations

Hart

2023

IJMS

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Pluripotent neural stem or progenitor cells (NSC/NPC) have been reported in the brains of adult preclinical models for decades, as have mesenchymal stem/stromal cells (MSC) been reported in a variety of tissues from adults. Based on their in vitro capabilities, these cell types have been used extensively in attempts to repair/regenerate brain and connective tissues, respectively. In addition, MSC have also been used in attempts to repair compromised brain centres. However, success in treating chronic neural degenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and others with NSC/NPC has been limited, as have the use of MSC in the treatment of chronic osteoarthritis, a condition affecting millions of individuals. However, connective tissues are likely less complex than neural tissues regarding cell organization and regulatory integration, but some insights have been gleaned from the studies regarding connective tissue healing with MSC that may inform studies attempting to initiate repair and regeneration of neural tissues compromised acutely or chronically by trauma or disease. This review will discuss the similarities and differences in the applications of NSC/NPC and MSC, where some lessons have been learned, and potential approaches that could be used going forward to enhance progress in the application of cellular therapy to facilitate repair and regeneration of complex structures in the brain. In particular, variables that may need to be controlled to enhance success are discussed, as are different approaches such as the use of extracellular vesicles from stem/progenitor cells that could be used to stimulate endogenous cells to repair the tissues rather than consider cell replacement as the primary option. Caveats to all these efforts relate to whether cellular repair initiatives will have long-term success if the initiators for neural diseases are not controlled, and whether such cellular initiatives will have long-term success in a subset of patients if the neural diseases are heterogeneous and have multiple etiologies.

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Blood and Cerebrospinal Fluid Biomarkers in Vascular Dementia and Alzheimer’s Disease

Cited by 8 publications

References 31 publications

A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

Review of Predator Emitted Volatile Organic Compounds and Their Potential for Predator Detection in New Zealand Forests

Use of Brain-Derived Stem/Progenitor Cells and Derived Extracellular Vesicles to Repair Damaged Neural Tissues: Lessons Learned from Connective Tissue Repair Regarding Variables Limiting Progress and Approaches to Overcome Limitations

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