Blood and aqueous humour antioxidants in cataractous poodles

Barros, P S M; Safatle, Angélica Mendonça Vaz; Queiroz, Lelio; Silva, Vanessa V.; Barros, S. B. M.

doi:10.1016/s0008-4182(04)80048-6

Cited by 14 publications

(15 citation statements)

References 20 publications

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“…As it is considered as one of the most important oxidative scavengers in the extracellular fluids [37] . The aforementioned results were in agreement with the previous studies [38,39] .…”

Section: Discussionsupporting

confidence: 94%

Histological and Immunohistochemical Study of the Possible Protective Effect of Ascorbic Acid on the Toxic Effect of Monosodium Glutamate on the Spleen of Adult Male Albino Rat

Mohamed

Abdelhaliem

Zakaria

2017

Egyptian Journal of Histology

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Introduction: Monosodium glutamate is widely used either as preservatives or enhancer of palatability. It is toxic to both human and experimental animals. Ascorbic acid is a natural antioxidant and has broad spectrum pharmacological properties. Aim of the work:The aim of the study was to determine the effect of monosodium glutamate on the structure of the spleen and to detect the efficacy of ascorbic acid to counteract these changes. Material and methods : Thirty adult albino rats were divided equally into three groups. Group I was the control group; group II rats were intraperitonialy injected with monosodium glutamate (4mg/kg/day) for 2 weeks; and group III, were treated with the same previous dose of monosodium glutamate and 500 mg/kg/day ascorbic A for 2 weeks. At the end of the experiment, specimens from the spleen were taken and prepared for H&E, Gomori silver stain and immunohistochemical stains (CD4 and CD68). Results: In group II, there were loss of architecture of the spleen and significant increase in area % of the reticular fibers. Megakaryocytes were frequently noticed. There was a significant decrease in the number of both CD4+ T helper cells and CD68+ macrophages in comparison with the control group. In group III, a marked improvement in the structure of the spleen was observed, and the number of both CD4+ and CD68+ cells were significantly increased as compared to group II. Conclusion: Monosodium glutamate had an immunosuppressive effect. Treatment with ascorbic acid was found to have protective role against this toxic effect.

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“…As it is considered as one of the most important oxidative scavengers in the extracellular fluids [37] . The aforementioned results were in agreement with the previous studies [38,39] .…”

Section: Discussionsupporting

confidence: 94%

Histological and Immunohistochemical Study of the Possible Protective Effect of Ascorbic Acid on the Toxic Effect of Monosodium Glutamate on the Spleen of Adult Male Albino Rat

Mohamed

Abdelhaliem

Zakaria

2017

Egyptian Journal of Histology

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“…However, the plasma MDA levels were significantly higher in POAG patients. 21,22 This could point out the fact that there is an ocular production of ROS. Some authors 23,24 have described the presence of oxidative agents in the aqueous humor, such as superoxide anion and hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Primary Open-angle Glaucoma

Zanón‐Moreno

Marco-Ventura

Lleó-Pérez

et al. 2008

Journal of Glaucoma

129

108

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“…Moreover vitamin C abolishes chromosome damage resulted from the effect of toxic substances and help to protect the body against pollutants. Because vitamin C is a biological reducing agent, it is also linked to preventive of degenerative diseases such as cataracts, certain cancer and cardiovascular disease (Barros et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Study of the Role of Antioxidant (Vitamin C) on Modulation Toxicity of Chronic Use of Monosodium Glutamate in Liver of Albino Rats

Osman

Elshama

El-Kenawy

2012

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction: Monosodium glutamate (MSG) is now used in many foodstuffs as a food additive and flavour enhancer. Although it has classified as safe food ingredient, the use of MSG remains controversial. MSG is a slow excitotoxin food additive which can cause generation of numerous amounts of free radicals which affects many organs such as liver. Vitamin C is an antioxidant and inhibits chemical carcinogenesis by protecting the body against oxidative stress. Aim of the study: Study role of antioxidant (vitamin C) on modulation biochemical, histological, histochemical and ultrastructural changes of liver caused by chronic use of MSG. Materials and Methods: Sixty adult albino rats divided into equal three groups, first group (control) received 1ml of saline daily for three months, Second group received MSG 6mg/g/BW/day for three months, third group received MSG 6mg/g/BW/day and vitamin C 500 mg /kg /b.w /day, orally and for three months. Biochemical changes were investigated by the liver function tests. Assessment of histopathological changes of liver was done by using light microscope, transmission electron microscope, histochemical studies and immuohistochemical studies. Results: After chronic use of MSG, light microscope and transmission electron microscope examination revealed severe histopathological changes such as hepatic architecture destruction and dilatations of the central veins with statistical significant increase of liver enzymes. Histochemical studies revealed severe reduction of carbohydrates and proteins; pyknotic nucleus, vacuolated cytoplasm, swollen mitochondria and vesiculated rough endoplasmic reticulum with significant positive stained nuclei with ki-67 and p53. Administration of Vitamin C with MSG led to significant improvement of biochemical and pathological changes of liver. Conclusions: Chronic use of MSG caused hepatotoxicty of rats which is improved by administration of Vitamin C with it.

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Blood and aqueous humour antioxidants in cataractous poodles

Cited by 14 publications

References 20 publications

Histological and Immunohistochemical Study of the Possible Protective Effect of Ascorbic Acid on the Toxic Effect of Monosodium Glutamate on the Spleen of Adult Male Albino Rat

Histological and Immunohistochemical Study of the Possible Protective Effect of Ascorbic Acid on the Toxic Effect of Monosodium Glutamate on the Spleen of Adult Male Albino Rat

Oxidative Stress in Primary Open-angle Glaucoma

Study of the Role of Antioxidant (Vitamin C) on Modulation Toxicity of Chronic Use of Monosodium Glutamate in Liver of Albino Rats

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