Blood Amino Acid Compartmentalization during Pregnancy and Lactation in the Rat

López-Tejero, Dolores; Pastor-Anglada, M; Remesar, Xavier

doi:10.1159/000177176

Cited by 12 publications

(5 citation statements)

References 19 publications

(22 reference statements)

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“…The effect of starvation on arterial amino acid concentrations of virgin and pregnant rats is less acute than that reported by others when amino acids were measured in plasma from mixed blood (Metzger et al, 1971 ;Zorzano et al, 1986). This may be explained by the changes reported to occur in blood amino acid compartmentalization during pregnancy (Lopez-Tejero et al, 1986) or starvation (Soley et al, 1982). In fact, plasma amino acid determinations usually mask whole-blood changes.…”

Section: Substrate Arterial Concentrationsmentioning

confidence: 86%

Hepatic uptake of amino acids in late-pregnant rats. Effect of food deprivation

Casado

Remesar

Pastor‐Anglada

1987

Biochemical Journal

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Hepatic availability, uptake and fractional extraction of amino acids were estimated in anaesthetized 21-day-pregnant and age-matched virgin rats, either fed or after 24 h starvation. Amino acid availability was unaltered in fed pregnant rats as compared with fed virgin controls. However, the hepatic uptake of these compounds was higher in the former than in the latter. These adaptations were mediated by an increase in the hepatic capability to take up amino acids in late-pregnant rats, as reflected by the changes found for the fractional extraction rates. The decrease in amino acid availability found after starvation was more pronounced in pregnant than in virgin rats. Nevertheless, the hepatic uptake was similar in both groups. These results indicate that amino acids are not limiting for ureagenesis during late pregnancy, strongly suggesting that the mechanism(s) which modulate urea synthesis may be intracellular in origin.

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Section: Substrate Arterial Concentrationsmentioning

confidence: 86%

Hepatic uptake of amino acids in late-pregnant rats. Effect of food deprivation

Casado

Remesar

Pastor‐Anglada

1987

Biochemical Journal

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“…Milder insufficiency of dietary protein may also accelerate the development of a number of diseases, such as obesity, within the MS spectrum [576,577]. The main effects observed include limited growth [578] and reproduction [579,580], negative N balance, and sarcopenia [581]. The clear need for amino acids in the diet, further than the essential amino acids and amino N provision, cannot be justified solely by these aspects, even when including the need for amino N to construe the large amount of essential molecules that incorporate this element, such as nucleic acid bases, porphyrins, or even small signaling molecules [506].…”

Section: The Importance Of Protein As Energy-providing Nutrient In Hu...mentioning

confidence: 99%

The Metabolic Syndrome, a Human Disease

Alemany

2024

IJMS

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This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of related but rather independent pathologies. The human nature of MS (its exceptionality in Nature and its close interdependence with human action and evolution) is presented and discussed. The text also describes the close interdependence of its components, with special emphasis on the description of their interrelations (including their syndromic development and recruitment), as well as their consequences upon energy handling and partition. The main theories on MS’s origin and development are presented in relation to hepatic steatosis, type 2 diabetes, and obesity, but encompass most of the MS components described so far. The differential effects of sex and its biological consequences are considered under the light of human social needs and evolution, which are also directly related to MS epidemiology, severity, and relations with senescence. The triggering and maintenance factors of MS are discussed, with especial emphasis on inflammation, a complex process affecting different levels of organization and which is a critical element for MS development. Inflammation is also related to the operation of connective tissue (including the adipose organ) and the widely studied and acknowledged influence of diet. The role of diet composition, including the transcendence of the anaplerotic maintenance of the Krebs cycle from dietary amino acid supply (and its timing), is developed in the context of testosterone and β-estradiol control of the insulin-glycaemia hepatic core system of carbohydrate-triacylglycerol energy handling. The high probability of MS acting as a unique complex biological control system (essentially monophyletic) is presented, together with additional perspectives/considerations on the treatment of this ‘very’ human disease.

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“…36 In contrast, gluconeo genic amino acids participate in the general decrease of circulating amino acids observed between the ninth and the twelfth day of rat pregnancy. 37 ' 38 Sev eral factors, as reviewed by Kalkhoff and associ ates, 39 may be responsible for the decline of amino acids in the maternal compartment. First, the fetus decreases amino acid availability by placental extrac tion.…”

Section: The "Paradox Of Low Basal Glucose Concentration In Late Gestmentioning

confidence: 99%