Blood 25-hydroxyvitamin D levels and overall mortality in patients with colorectal cancer: A dose–response meta-analysis

Wang, Bin; Jing, Zhaohai; Li, Chengqian; Xu, Shousen; Wang, Yangang

doi:10.1016/j.ejca.2014.05.004

Cited by 19 publications

(10 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, some meta-analyses (32)(33)(34)(35)(36) focused on the impact of vitamin D on the prognosis of colorectal cancer. Some of the limitations among these studies are as follows: the articles included are not comprehensive, with only three to five relative articles included (32)(33)(34)(35)(36) and the articles included were repeated. For example, two related papers published in 2008 (37) and 2009 (15) respectively were based on the same population.…”

Section: Discussionmentioning

confidence: 99%

“…However, reviews by Mohra et al (33) and Toriola et al (31) contained both of them. Some articles assessed the prognostic impact of vitamin D on multiple tumors, which meant that there was no detailed discussion on the pooled HR and obvious heterogeneity or publication bias (31,35); some articles were published in the form of editorials and the specific extraction of data was unknown (33,34); some articles only emphasized fitting the dose-response curve without providing a detailed analysis of the pooled HR, heterogeneity, sensitivity or publication bias (33,34); and some articles did not show a fitting result for the dose-response relationship (31,32,35). Therefore, we pooled comprehensive and high-quality prospective studies conducted over the past decade to perform a detailed systematic and comprehensive quantitative analysis to fill the gap in this field.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Yuan

et al. 2018

Journal of Nutritional Science and Vitaminology

View full text Add to dashboard Cite

A higher serum 25-hydroxyvitamin D (25(OH)D) concentration benefits colorectal cancer prevention. However, whether it can improve the prognosis among patients is still under discussion. This study aims to explore the impacts of high level 25(OH)D on the survival of colorectal cancer patients. PubMed, Embase, and Cochrane were searched from January 2000 to August 2017 for relevant articles. Only published studies focusing on the relationship between 25(OH)D levels at or near the time of diagnosis and survival were considered. Two review authors independently assessed the risk of bias for each study, and any disagreement was resolved by discussion or by involving a third assessor. Eleven studies comprising 7,367 patients were included. In these studies, there were considerable differences between the higher 25(OH)D level group and the lower group in terms of overall survival (OS), progression-free survival (PFS) and colorectal cancer-specific survival (CSS) in a random effect model (OS: HR 0.67, 95% CI 0.56-0.80, p,0.00001; CSS: HR 0.73, 95% CI 0.55-0.97, p50.03; PFS: HR 0.74, 95% CI 0.61-0.90, p50.003). Moreover, the combined hazard ratios of OS and CSS had considerably significant heterogeneity which may be explained by subgroup analysis. The relationship between 25(OH)D and tumor characteristics/lifestyle factors was also included in the meta-analysis. BMI (p50.03), smoking (p50.03) and physical activity (p50.002) seemed to be associated with circulating 25(OH)D level. Publication bias was undetected. Colorectal cancer patients with higher circulating 25(OH)D level may have a better prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Yuan

et al. 2018

Journal of Nutritional Science and Vitaminology

View full text Add to dashboard Cite

show abstract

“…There are also many studies assessing the association between circulating levels of vitamin D and the prognosis of cancer patients [35,36]. Previous studies also provided some evidence for the prognostic roles of serum vitamin D levels in colorectal cancer and breast cancer [35,37].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Lung Cancer Risk: A Comprehensive Review and Meta-Analysis

Zhang

Si-hai

Che

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aim: Vitamin D has been suggested to have important roles against cancer development. There were several published studies on the association between vitamin D and lung cancer risk, but not conclusive results were available. Methods: To clarify the role of vitamin D in lung carcinogenesis, we performed a comprehensive review of the literature and a meta-analysis to evaluate the association of serum vitamin D levels and dietary vitamin D intake with lung cancer risk. Twelve studies (9 prospective cohort and 3 nested case-control studies) with a total of 288,778 individuals were included. The summary relative risk (RR) with 95% confidence interval (CI) was used to assess lung cancer risk. Results: Meta-analysis of total 12 studies showed that RR for the association of high vitamin D status with lung cancer was 0.84 (95%CI 0.78-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of serum vitamin D levels was 0.83 (95%CI 0.77-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of vitamin D intake was 0.89 (95%CI 0.74-1.06, P = 0.184). Conclusion: Current data suggest an inverse association between serum vitamin D and lung cancer risk. Further studies are needed to investigate the effect of vitamin D intake on lung cancer risk and to evaluate whether vitamin D supplementation can prevent lung cancer.

show abstract

“…Survival of colorectal cancer is positively associated with vitamin D status (25-hydroxyvitamin D). This association is observed in prospective cohort studies and is summarized in multiple reviews, including two meta-analyses (3)(4)(5)(6)(7)(8). These meta-analyses were based on five prospective cohort studies in patients with colorectal cancer in which vitamin D status was measured pre-or postdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies

Harten-Gerritsen

Balvers

Witkamp

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Survival from colorectal cancer is positively associated with vitamin D status. However, whether this association is causal remains unclear. Inflammatory processes may link vitamin D to colorectal cancer survival, and therefore investigating inflammatory markers as potential mediators may be a valuable next step. This review starts with an overview of inflammatory processes suggested to be involved in colorectal cancer progression and regulated by vitamin D. Next, we provide recommendations on how to study inflammatory markers in future epidemiologic studies on vitamin D and colorectal cancer survival. Mechanistic studies have shown that calcitriol-active form of vitamin Dinfluences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kB pathway, and the expression of the cytokines TNFa, IL1b, IL6, IL8, IL17, and TGFb1. Based on this and taking into account methodologic issues, we recommend to include analysis of specific soluble peptides and proteins, such as cytokines, in future epidemiologic studies on this issue. Vitamin D and the markers should preferably be measured at multiple time points during disease progression or recovery and analyzed using mediation analysis. Including these markers in epidemiologic studies may help answer whether inflammation mediates a causal relationship between vitamin D and colorectal cancer survival. Cancer Epidemiol Biomarkers Prev; 24(12); 1820-8. Ó2015 AACR.

show abstract

Blood 25-hydroxyvitamin D levels and overall mortality in patients with colorectal cancer: A dose–response meta-analysis

Cited by 19 publications

References 9 publications

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Vitamin D and Lung Cancer Risk: A Comprehensive Review and Meta-Analysis

Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies

Contact Info

Product

Resources

About