Blocking the entrance of AMP pocket results in hormetic stimulation of imidazolium-based ionic liquids to firefly luciferase

Fu, Cuicui; Liu, Shu-Shen; Yu, Mo; Qu, Rui; Wang, Meng-Chao

doi:10.1016/j.chemosphere.2015.03.030

Cited by 15 publications

(7 citation statements)

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“…This implies that another distinct signalling pathway is activated in response to this level of exposure, which poses the question to what type of mechanism may contribute to such hormetic or adaptive response to NP treatment. Receptor-mediated and cell signalling-mediated bidirectional control of gene expression has been considered as the main hormetic mechanism triggered by exposure to chemicals [58]. It is reported that hormesis likely depends upon changes in the regulation of genes critical for OS resistance [55,59].…”

Section: Discussionmentioning

confidence: 99%

Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways

Duan

Butler

et al. 2016

Reproductive Toxicology

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This study tested the hypothesis that prepubertal exposure to 4-nonylphenol (NP) affects reproductive function in male rats. Twenty-four rats at five-weeks-old were randomly divided into four groups and treated with NP at varying concentrations (0, 5, 20, and 60mg/kg/2d) for thirty days by intra-peritoneal injection. 60mg/kg NP induced spermatogenic degeneration and pronounced deficits in epididymal sperm count, motility and function, whereas potentially stimulatory effects were observed at 5 NPmg/kg. Moreover, 60mg/kg NP resulted in a significant reduction in fructose, FSH and LH; induced apoptosis related to oxidative stress; inhibited mRNA and protein levels of Bcl-2 and PCNA; as well as the additional up-regulation of p53, Bax, Apaf-1, cytochrome c, cleaved-caspase-3, Fas and FasL expression. Our data suggest potentially hormetic effects of NP on spermatogenic function. High-dose NP impairs testicular development and function by reducing cell proliferation and inducing apoptosis involving oxidative stress-related p53-Bcl-2/Bax and -Fas/FasL pathways.

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Section: Discussionmentioning

confidence: 99%

Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways

Duan

Butler

et al. 2016

Reproductive Toxicology

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“…In this light, the present results suggest a hormetic-like biphasic dose-response association of MEHP in Sertoli cells. Cell signaling-mediated bidirectional control of gene expression has been considered as the major hormetic mechanism triggered by exposure to xenobiotics (47). This indicates that 'terpenoid backbone biosynthesis' and 'steroid biosynthesis' signaling pathways were activated in response to this low level of exposure.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome profiling and pathway analysis of the effects of mono‑(2‑ethylhexyl) phthalate in mouse Sertoli cells

Wang

Dou

et al. 2019

Exp Ther Med

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Phthalates are confirmed to have toxic effects on the reproductive system and are likely to have further damaging actions in humans. The present study explored the molecular mechanisms of the toxic effect of mono-(2-ethylhexyl) phthalate (MEHP) on mouse Sertoli cells. Cell apoptosis and proliferation assays were used to assess the effects of MEHP on the TM4 Sertoli cell line derived from mouse testes. TM4 cells were treated with two doses of MEHP or left untreated as a control group, followed by RNA extraction and analysis using high-throughput transcriptome sequencing technology. The gene expression profile obtained was then subjected to a bioinformatics analysis to explore the molecular mechanisms of reproductive toxicity. The results revealed that 528 and 269 genes were upregulated in the high-and low-dose MEHP groups of cells compared with the control group, while 148 and 173 genes were downregulated. Gene ontology (GO) analysis indicated that the differently expressed genes were associated with the GO term 'extracellular region' of the cellular component domain in the high and low MEHP groups. Compared with the control group, eight common pathway changes were identified in the high-and low-dose MEHP groups, including 'terpenoid backbone biosynthesis'. Reverse transcription-quantitative polymerase chain reaction analysis was used to validation, and hermetic effects were observed for certain genes. These results provide an important basis and experimental data for further research into the mechanisms of phthalate-induced toxicity.

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“…29 and is good for describing U-shaped dose-response curves of the type found in Pharmacology and the curves normalized relative to controls. Ge et al (2011) and Chen et al (2015) used this simplified version of eq. 31 to adequately describe the hormetic effects of mixtures of ionic liquids on luciferase activity.…”

Section: Bi-logistic Hormesis Modelsmentioning

confidence: 99%

Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies

Nweke¹,

Ogbonna²

2024

Ecotoxicol. Environ. Contam.

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The dose-response phenomenon characterized by low dose stimulation and high dose toxicity has been reawakened after a long period of marginalization. This phenomenon termed hormesis is induced by biological, physical and chemical agents and occurs in all groups of living things including whole plants and animals, microorganisms, cells and tissues. Hormesis has attracted increased interest among toxicologists from diverse disciplines, resulting to emergence of new scientific tools for its study. Statistical models have been developed and used to characterize hormesis dose-response relationships. Some of these models include the classical Brain-Cousens model, the Cedergreen-Ritz-Streibig model and their reparameterizations. Other hormesis models are the bilogistic models, their modifications or extensions and the hormesis models used in allelopathy such as An-Johnson-Lovett model. These models are used to describe either U-shaped or inverted U-shaped dose-response relationships and to compute hormesis quantities. This review explored the applications of these models in toxicological studies with emphasis to their strengths and weaknesses.

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Blocking the entrance of AMP pocket results in hormetic stimulation of imidazolium-based ionic liquids to firefly luciferase

Cited by 15 publications

References 50 publications

Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways

Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways

Transcriptome profiling and pathway analysis of the effects of mono‑(2‑ethylhexyl) phthalate in mouse Sertoli cells

Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies

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