Blocking soluble guanylate cyclase could be the present and future of NO/cGMP inhibition for vasoplegia treatment

Évora, Paulo Roberto Barbosa

doi:10.1186/s13054-018-2024-y

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Levy and colleagues wrote an excellent review article about the “past, present and future” of vasoplegia treatment and expressed some concerns about the use of MB [303]. Without considering MB itself, the blockade of soluble sGC, the final NO/cGMP messenger, in smooth muscle is underestimated and deserves a place in the present and future [303,304].…”

Section: Therapeutics: the Pharmacological Approachmentioning

confidence: 99%

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

Soares

Losada

Jordani

et al. 2019

IJMS

240

180

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Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous concern in every transplantation proceeding, from whole organs to modest grafts. Given its significance, efforts to evade the damaging effects of both ischemia and reperfusion are abundant in the literature and they consist of several strategies, such as applying pre-ischemic conditioning protocols, improving protection from preservation solutions, thus providing extended cold ischemia time and so on. In this review, we describe many of the latest pharmacological approaches that have been proven effective against IRI, while also revisiting well-established concepts and presenting recent pathophysiological findings in this ever-expanding field. A plethora of promising protocols has emerged in the last few years. They have been showing exciting results regarding protection against IRI by employing drugs that engage several strategies, such as modulating cell-surviving pathways, evading oxidative damage, physically protecting cell membrane integrity, and enhancing cell energetics.

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Section: Therapeutics: the Pharmacological Approachmentioning

confidence: 99%